Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yaman Lu"'
Autor:
Pravin Yeapuri, Jatin Machhi, Yaman Lu, Mai Mohamed Abdelmoaty, Rana Kadry, Milankumar Patel, Shaurav Bhattarai, Eugene Lu, Krista L. Namminga, Katherine E. Olson, Emma G. Foster, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of defined antigen specificity limits their therapeutic potential. This is notable for neurodegen
Externí odkaz:
https://doaj.org/article/e41efd3b0d7a4a99bcf11d2d1852d2b7
Autor:
Katherine E. Olson, Mai M. Abdelmoaty, Krista L. Namminga, Yaman Lu, Helen Obaro, Pamela Santamaria, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-17 (2023)
Abstract Background The clinical utility and safety of sargramostim has previously been reported in cancer, acute radiation syndrome, autoimmune disease, inflammatory conditions, and Alzheimer’s disease. The safety, tolerability, and mechanisms of
Externí odkaz:
https://doaj.org/article/6aff7aaecbfb4f87a699e0984d9801ed
Autor:
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-23 (2021)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in kind facilitates tau aggregation and neurodegeneration. Neuroinf
Externí odkaz:
https://doaj.org/article/9566142d7b6b497fa6e8c5d16550ee05
Autor:
Katherine E. Olson, Krista L. Namminga, Yaman Lu, Aaron D. Schwab, Mackenzie J. Thurston, Mai M. Abdelmoaty, Vikas Kumar, Melinda Wojtkiewicz, Helen Obaro, Pamela Santamaria, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103380- (2021)
Background: Neuroinflammation plays a pathogenic role in Parkinson's disease (PD). Immunotherapies that restore brain homeostasis can mitigate neurodegeneration by transforming T cell phenotypes. Sargramostim has gained considerable attention as an i
Externí odkaz:
https://doaj.org/article/42564ef1ed174676ac5a8c08781fbe1f
Autor:
Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Gang Zhang, R. Lee Mosley, Harris A. Gelbard, Howard E. Gendelman
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background The mixed lineage kinase type 3 inhibitor URMC-099 facilitates amyloid-beta (Aβ) clearance and degradation in cultured murine microglia. One putative mechanism is an effect of URMC-099 on Aβ uptake and degradation. As URMC-099 p
Externí odkaz:
https://doaj.org/article/5e812dd4918b4a7d931a58a4dc7b2405
Autor:
Howard E. Gendelman, Yuning Zhang, Pamela Santamaria, Katherine E. Olson, Charles R. Schutt, Danish Bhatti, Bhagya Laxmi Dyavar Shetty, Yaman Lu, Katherine A. Estes, David G. Standaert, Elizabeth Heinrichs-Graham, LuAnn Larson, Jane L. Meza, Matthew Follett, Erica Forsberg, Gary Siuzdak, Tony W. Wilson, Carolyn Peterson, R. Lee Mosley
Publikováno v:
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-12 (2017)
Immune modulation: translating the benefits The immune system modulating drug sargramostim shows promising results in a small clinical trial with Parkinson’s disease (PD) patients. Previous studies have shown that sargramostim increases the number
Externí odkaz:
https://doaj.org/article/ee69bcd53fbd419bb5945c4e0f267aba
Autor:
R. Lee Mosley, Yaman Lu, Katherine E. Olson, Jatin Machhi, Wenhui Yan, Krista L. Namminga, Jenell R. Smith, Scott J. Shandler, Howard E. Gendelman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
A paradigm shift has emerged in Parkinson’s disease (PD) highlighting the prominent role of CD4+ Tregs in pathogenesis and treatment. Bench to bedside research, conducted by others and our own laboratories, advanced a neuroprotective role for Tregs
Externí odkaz:
https://doaj.org/article/1507b190c871468cb0e79ad1d797cc86
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21707 (2011)
Despite the advent of antiretroviral therapy, complications of HIV-1 infection with concurrent drug abuse are an emerging problem. Morphine, often abused by HIV-infected patients, is known to accelerate neuroinflammation associated with HIV-1 infecti
Externí odkaz:
https://doaj.org/article/32a6e6edc3754a40b77e3223f85af9cf
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13427 (2010)
It is becoming widely accepted that psychoactive drugs, often abused by HIV-I infected individuals, can significantly alter the progression of neuropathological changes observed in HIV-associated neurodegenerative diseases (HAND). The underlying mech
Externí odkaz:
https://doaj.org/article/bdf206c4f4024c8885ca07c67a0816e2
Autor:
Pravin Yeapuri, Katherine E. Olson, Yaman Lu, Mai Mohamed Abdelmoaty, Krista L. Namminga, Milica Markovic, Jatin Machhi, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Journal of Controlled Release. 348:951-965
Transformation of CD4+ T cell effector to regulatory (Teff to Treg) cells have been shown to attenuate disease progression by restoring immunological balance during the onset and progression of neurodegenerative diseases. In our prior studies, we def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b823077b2c16a06034f04d2515102242
https://doi.org/10.1016/j.jconrel.2022.06.024
https://doi.org/10.1016/j.jconrel.2022.06.024