Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yamami Nakamura"'
Autor:
Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, Makoto Kinoshita, Soichiro Funaki, Satoshi Nojima, Kansuke Kido, Masaharu Kohara, Daisuke Motooka, Daisuke Okuzaki, Shuji Suganami, Eriko Takeuchi, Yamami Nakamura, Yusuke Takeshima, Masaya Arai, Satoru Tada, Meinoshin Okumura, Eiichi Morii, Yasushi Shintani, Shimon Sakaguchi, Tatsusada Okuno, Hideki Mochizuki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Myasthenia Gravis and thymoma are frequently associated with patients suffering from both diseases. Here the authors perform single cell sequencing of thymoma and find that there are autoimmune antigens such as neuromuscular proteins expressed aberra
Externí odkaz:
https://doaj.org/article/2570824143ef4a838ef3341d99555822
Autor:
Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura, Hisashi Wada
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective
Externí odkaz:
https://doaj.org/article/51a74d2b5acc4db8a5531e85252d6b2f
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101694- (2022)
Summary: The establishment of regulatory T cells (Treg)-specific demethylation regions (TSDRs) is essential for the Treg-lineage stability. Here, we present a protocol using bisulfite sequencing to assess Treg-lineage stability. The protocol describe
Externí odkaz:
https://doaj.org/article/56d8e6cfa2a8432eb2ad36787a6e8a54
Autor:
Yoshiaki Yasumizu, Daiki Takeuchi, Reo Morimoto, Yusuke Takeshima, Tatsusada Okuno, Makoto Kinoshita, Takayoshi Morita, Yasuhiro Kato, Min Wang, Daisuke Motooka, Daisuke Okuzaki, Yamami Nakamura, Norihisa Mikami, Masaya Arai, Xuan Zhang, Atsushi Kumanogoh, Hideki Mochizuki, Naganari Ohkura, Shimon Sakaguchi
CD4+T cells are a key mediator of various autoimmune diseases; however, how they contribute to disease development remains obscure primarily because of their cellular heterogeneity. Here, we evaluated CD4+T cell subpopulations by decomposition-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd3893fb5a677111a90680ae5f7760d
https://doi.org/10.1101/2023.05.09.540089
https://doi.org/10.1101/2023.05.09.540089
Autor:
Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro Doki, Naganari Ohkura, Shimon Sakaguchi
Publikováno v:
Proceedings of the National Academy of Sciences. 119
SignificanceImmunosuppressive Foxp3-expressing regulatory T cells (Tregs) in tumor tissues are assumed to be clonally expanding via recognizing tumor-associated antigens. By single-cell RNA sequencing, we have searched for the molecules that are spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4710bc2308f5adf752d06c10e3ca4b
https://doi.org/10.1073/pnas.2114282119
https://doi.org/10.1073/pnas.2114282119
Autor:
Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, Makoto Kinoshita, Soichiro Funaki, Satoshi Nojima, Kansuke Kido, Masaharu Kohara, Daisuke Motooka, Daisuke Okuzaki, Shuji Suganami, Eriko Takeuchi, Yamami Nakamura, Yusuke Takeshima, Masaya Arai, Satoru Tada, Meinoshin Okumura, Eiichi Morii, Yasushi Shintani, Shimon Sakaguchi, Tatsusada Okuno, Hideki Mochizuki
Myasthenia gravis (MG) is a neurological disease caused by autoantibodies against neuromuscular-associated proteins. While MG is frequently developed in thymoma patients, the etiologic factors for MG are not well understood. Here, by constructing a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f9384c9b94f53136872d8f71daa4c0
https://doi.org/10.1101/2021.12.19.473411
https://doi.org/10.1101/2021.12.19.473411
Autor:
Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura, Hisashi Wada
Publikováno v:
Scientific reports. 12(1)
Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective CCR8 exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad897718e284fa4cb0312185d9a6babd
https://pubmed.ncbi.nlm.nih.gov/35354899
https://pubmed.ncbi.nlm.nih.gov/35354899
Autor:
Yohko Kitagawa, Keiko Yasuda, Norihisa Mikami, Masaya Arai, Hitomi Watanabe, Kelvin Y. Chen, Gen Kondoh, Daiya Ohara, Motonao Osaki, Yamami Nakamura, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi, Ryoji Kawakami, Caleb A. Lareau
Publikováno v:
Immunity. 54(5)
The transcription factor Foxp3 plays crucial roles for Treg cell development and function. Conserved non-coding sequences (CNSs) at the Foxp3 locus control Foxp3 transcription, but how they developmentally contribute to Treg cell lineage specificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0756489f71606474379b0a960ffb09e
https://pubmed.ncbi.nlm.nih.gov/33930308
https://pubmed.ncbi.nlm.nih.gov/33930308
Autor:
Naganari Ohkura, Shota Nakamura, Yukinori Okada, Yoshiaki Yasumizu, Yamami Nakamura, Yohko Kitagawa, Daisuke Motooka, Atsushi Tanaka, Shimon Sakaguchi
Publikováno v:
Immunity. 52:1119-1132.e4
The contribution of FOXP3-expressing naturally occurring regulatory T (Treg) cells to common polygenic autoimmune diseases remains ambiguous. Here, we characterized genome-wide epigenetic profiles (CpG methylation and histone modifications) of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0437bfe8ef4130e5ec37fb9450b97018
https://doi.org/10.1016/j.immuni.2020.04.006
https://doi.org/10.1016/j.immuni.2020.04.006