A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Autor: Toda, Narihiro, Tago, Keiko, Marumoto, Shinji, Takami, Kazuko, Ori, Mayuko, Yamada, Naho, Koyama, Kazuo, Naruto, Shunji, Abe, Kazumi, Yamazaki, Reina, Hara, Takao, Aoyagi, Atsushi, Abe, Yasuyuki, Kaneko, Tsugio, Kogen, Hiroshi

Publikováno v: In Bioorganic & Medicinal Chemistry 2003 11(20):4389-4415

Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer’s Disease

Autor: Abe, Yasuyuki, Aoyagi, Atsushi, Hara, Takao, Abe, Kazumi, Yamazaki, Reina, Kumagae, Yoshihiro, Naruto, Shunji, Koyama, Kazuo, Marumoto, Shinji, Tago, Keiko, Toda, Narihiro, Takami, Kazuko, Yamada, Naho, Ori, Mayuko, Kogen, Hiroshi, Kaneko, Tsugio

Publikováno v: In Journal of Pharmacological Sciences 2003 93(4):95-105

Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease.

Autor: Kogen H; Exploratory Chemistry Research Laboratories, Research Information Department, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. hkogen@shina.sankyo.co.jp, Toda N, Tago K, Marumoto S, Takami K, Ori M, Yamada N, Koyama K, Naruto S, Abe K, Yamazaki R, Hara T, Aoyagi A, Abe Y, Kaneko T

Publikováno v: Organic letters [Org Lett] 2002 Oct 03; Vol. 4 (20), pp. 3359-62.