Effect of the of 10-valent pneumococcal conjugate vaccine in Nepal 4 years after introduction: an observational cohort study

Autor: Shrijana Shrestha, ProfMD, Meeru Gurung, MD, Puja Amatya, MD, Sanjeev Bijukchhe, MSc, Anindya Sekhar Bose, MD, Michael J Carter, DPhil, Madhav C Gautam, MSc, Sunaina Gurung, MBBS, Jason Hinds, PhD, Rama Kandasamy, DPhil, Sarah Kelly, MSc, Bibek Khadka, MSc, Pratistha Maskey, MBBS, Yama F Mujadidi, MSc, Peter J O’Reilly, MSc, Bhishma Pokhrel, MD, Rahul Pradhan, MSc, Ganesh P Shah, MD, Sonu Shrestha, MSc, Brian Wahl, PhD, Katherine L O’Brien, MD, Maria Deloria Knoll, PhD, David R Murdoch, ProfMD, Dominic F Kelly, PhD, Stephen Thorson, MD, Merryn Voysey, DPhil, Andrew J Pollard, ProfFMedSci, Kalpana Acharya, Baikuntha Acharya, Imran Ansari, Ruby Basi, Shriya Bista, Sabitri Bista, Arjun Kumar Budha, Saraswati Budhathoki, Rasmila Deshar, Swati Dhungel, Sally Felle, Kushal Gautam, Katie Gorham, Tshering Yanyzon Gurung, Pallavi Gurung, Roshan Jha, Manisha K.C, Shirty Raj Karnikar, Anushiya Kattel, Laxmi Lama, Tham Kumari Pun Magar, Mamata Maharjan, Anshu Mallik, Alexandra Michel, Diksha Nepal, Jita Nepal, Kate M Park, Krishna Govinda Prajapati, Rupa Pudasaini, Subash Shrestha, Matthew Smedley, Rose Weeks, Jyoti Kumari Yadav, Sonu Kumar Yadav

Publikováno v: The Lancet Global Health, Vol 10, Iss 10, Pp e1494-e1504 (2022)

Summary: Background: In Nepal, Streptococcus pneumoniae (pneumococcus) is a common cause of bacterial pneumonia in children, and is a major health concern. There are few data on the effect of vaccination on the disease or colonisation with pneumococc

Externí odkaz: https://doaj.org/article/15585aa5cfdc4bbc802f34db6156463c

Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model.

Autor: Malick M Gibani, Celina Jin, Sonu Shrestha, Maria Moore, Lily Norman, Merryn Voysey, Elizabeth Jones, Luke Blackwell, Helena Thomaides-Brears, Jennifer Hill, Christoph J Blohmke, Hazel C Dobinson, Philip Baker, Claire Jones, Danielle Campbell, Yama F Mujadidi, Emma Plested, Lorena Preciado-Llanes, Giorgio Napolitani, Alison Simmons, Melita A Gordon, Brian Angus, Thomas C Darton, Vincenzo Cerundulo, Andrew J Pollard

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008783 (2020)

Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood. Prior exposure is thought to confer partial, but incomplete, p

Externí odkaz: https://doaj.org/article/f70f1ff1116542f5a775b4d8d3b849ca

Booster Vaccination Against SARS-CoV-2 Induces Potent Immune Responses in People With Human Immunodeficiency Virus

Autor: Sarah Fidler, Julie Fox, Timothy Tipoe, Stephanie Longet, Tom Tipton, Movin Abeywickrema, Sandra Adele, Jasmini Alagaratnam, Mohammad Ali, Parvinder K Aley, Suhail Aslam, Anbhu Balasubramanian, Anna Bara, Tanveer Bawa, Anthony Brown, Helen Brown, Federica Cappuccini, Sophie Davies, Jamie Fowler, Leila Godfrey, Anna L Goodman, Kathrine Hilario, Carl-Philipp Hackstein, Moncy Mathew, Yama F Mujadidi, Alice Packham, Claire Petersen, Emma Plested, Katrina M Pollock, Maheshi N Ramasamy, Hannah Robinson, Nicola Robinson, Patpong Rongkard, Helen Sanders, Teona Serafimova, Niamh Spence, Anele Waters, Danielle Woods, Panagiota Zacharopoulou, Eleanor Barnes, Susanna Dunachie, Philip Goulder, Paul Klenerman, Alan Winston, Adrian V S Hill, Sarah C Gilbert, Miles Carroll, Andrew J Pollard, Teresa Lambe, Ane Ogbe, John Frater

Publikováno v: Clinical Infectious Diseases. 76:201-209

Background People with human immunodeficiency virus (HIV) on antiretroviral therapy (ART) with good CD4 T-cell counts make effective immune responses following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38f71eab9e339098334622c801bea676
https://doi.org/10.1093/cid/ciac796

Persistence of the immune response after two doses of ChAdOx1 nCov-19 (AZD1222): 1 year of follow up of two randomised controlled trials

Autor: Merryn Voysey, Amy Flaxman, Jeremy Aboagye, Parvinder K Aley, Sandra Belij-Rammerstorfer, Sagida Bibi, Mustapha Bittaye, Federica Cappuccini, Sue Charlton, Elizabeth A Clutterbuck, Sophie Davies, Christina Dold, Nick J Edwards, Katie J Ewer, Saul N Faust, Pedro M Folegatti, Jamie Fowler, Ciaran Gilbride, Sarah C Gilbert, Leila Godfrey, Bassam Hallis, Holly E Humphries, Daniel Jenkin, Simon Kerridge, Yama F Mujadidi, Emma Plested, Maheshi N Ramasamy, Hannah Robinson, Helen Sanders, Matthew D Snape, Rinn Song, Kelly M Thomas, Marta Ulaszewska, Danielle Woods, Daniel Wright, Andrew J Pollard, Teresa Lambe

The trajectory of immune responses following the primary dose series determines the decline in vaccine effectiveness over time. Here we report on maintenance of immune responses during the year following a two-dose schedule of ChAdOx1 nCoV-19/AZD1222

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca008dfeea2ae68ee3c352ef24ca2bb
https://doi.org/10.1093/cei/uxad013

Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial

Autor: Robert H Shaw, Xinxue Liu, Arabella S V Stuart, Melanie Greenland, Parvinder K Aley, Nick J Andrews, J Claire Cameron, Sue Charlton, Elizabeth A Clutterbuck, Andrea M Collins, Wanwisa Dejnirattisai, Tanya Dinesh, Saul N Faust, Daniela M Ferreira, Adam Finn, Christopher A Green, Bassam Hallis, Paul T Heath, Helen Hill, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Fei Long, Yama F Mujadidi, Emma L Plested, Ella R Morey, Samuel Provstgaard-Morys, Maheshi N Ramasamy, Mary Ramsay, Robert C Read, Hannah Robinson, Gavin R Screaton, Nisha Singh, David P J Turner, Paul J Turner, Iason Vichos, Laura L Walker, Rachel White, Jonathan S Nguyen-Van-Tam, Matthew D Snape, Alasdair P.S. Munro, Jazz Bartholomew, Laura Presland, Sarah Horswill, Sarah Warren, Sophie Varkonyi-Clifford, Stephen Saich, Kirsty Adams, Marivic Ricamara, Nicola Turner, Nicole Y. Yee Ting, Sarah Whittley, Tommy Rampling, Amisha Desai, Claire H. Brown, Ehsaan Qureshi, Karishma Gokani, Kush Naker, Johanna K. Kellett Wright, Rachel L. Williams, Tawassal Riaz, Florentina D. Penciu, Amy Carson, Claudio Di Maso, Gracie Mead, Elizabeth G. Howe, Mujtaba Ghulam Farooq, Rabiullah Noristani, Xin L. Yao, Neil J. Oldfield, Daniel Hammersley, Sue Belton, Simon Royal, Alberto San Francisco Ramos, Cecilia Hultin, Eva P. Galiza, Rebecca Crook, Marcin Bula, Fred Fyles, Hassan Burhan, Flora Maelin, Elen Hughes, Emmanuel Okenyi

Publikováno v: Shaw, R H, Liu, X, Stuart, A S V, Greenland, M, Aley, P K, Andrews, N J, Finn, A & Lazarus, R & et, A 2022, ' Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules : exploratory analyses of Com-COV, a randomised control trial ', Lancet Respiratory Medicine, vol. 10, no. 11, pp. 1049-1060 . https://doi.org/10.1016/S2213-2600(22)00163-1

Background Priming COVID-19 vaccine schedules have been deployed at variable intervals globally, which might influence immune persistence and the relative importance of third-dose booster programmes. Here, we report exploratory analyses from the Com-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed4ea510bf1be44fbc2afbfb9cf0590
https://eprints.soton.ac.uk/456454/