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Akademický článek

Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients

Publikováno v: npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-16 (2022)

Abstract Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monol

Externí odkaz: https://doaj.org/article/2fa050a5687248eaa0da9d23e96a5eb4

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A Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients

Autor: Renata Santos, Fred H. Gage, Anne G. Bang, Arianna Mei, Dekel Galor, Martin Alda, Shani Stern, Tchelet Stern, Yam Stern, Maria C. Marchetto, Anindita Sarkar, Lynne Randolph-Moore, Ana P.D. Mendes, Guy A. Rouleau

Publikováno v: Biological Psychiatry. 88:150-158

Background We recently reported a hyperexcitability phenotype displayed in dentate gyrus granule neurons derived from patients with bipolar disorder (BD) as well as a hyperexcitability that appeared only in CA3 pyramidal hippocampal neurons that were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff43e7928674370fb62bdbdb23771089
https://doi.org/10.1016/j.biopsych.2020.01.020

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Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson’s disease patients

Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15-25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monolithic disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b45c602fcde062bde33415f1c163fa90
https://doi.org/10.1101/2021.12.31.474654

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Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients

Publikováno v: NPJ Parkinson's disease. 8(1)

Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monolithic dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d394959dd0d88394063b9d3023639cb
https://pubmed.ncbi.nlm.nih.gov/35948563

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IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission

Autor: Liron Mizrahi, Ayat Asleh, Boris Brant, Andrew P. Levy, Reem Jada, George K.E. Umanah, Tchelet Stern, Nina S. Levy, Shani Stern, Idan Rosh, Huda Adwan Shekhidem, Yam Stern, Polina Ofer

Publikováno v: Molecular psychiatry. 26(12)

Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and childhood epilepsy; autism; and severe intellectual disability (ID). We used induced pluripotent stem cell (iPSC) technology to obtain hippocampal neurons to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256016cd8f82b5db949b43615541c727
https://pubmed.ncbi.nlm.nih.gov/34535765

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Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder

Autor: Guy A. Rouleau, Tchelet Stern, Thao Nguyen, Yongsung Kim, Gabriela Goldberg, Ana P.D. Mendes, Anne G. Bang, Renata Santos, Arianna Mei, Anindita Sarkar, Dekel Galor, Lynne Randolph-Moore, Fred H. Gage, Yam Stern, Maria C. Marchetto, Shani Stern, Martin Alda

Publikováno v: Biological Psychiatry
Biological Psychiatry, Elsevier, 2019, ⟨10.1016/j.biopsych.2019.09.018⟩
Biol Psychiatry

Background Approximately 1 in every 50 to 100 people is affected with bipolar disorder (BD), making this disease a major economic burden. The introduction of induced pluripotent stem cell methodology enabled better modeling of this disorder. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155dd9689d0a07bfd3f9d1f7de76978f
https://pubmed.ncbi.nlm.nih.gov/32616198

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