Allosteric communication and signal transduction in proteins.

Autor: Wu N; Department of Chemistry, Imperial College London, United Kingdom., Barahona M; Department of Mathematics, Imperial College London, United Kingdom. Electronic address: https://twitter.com/@CMPHImperial., Yaliraki SN; Department of Chemistry, Imperial College London, United Kingdom. Electronic address: s.yaliraki@imperial.ac.uk.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2024 Feb; Vol. 84, pp. 102737. Date of Electronic Publication: 2024 Jan 03.

Severability of mesoscale components and local time scales in dynamical networks

Autor: Yu, YW, Delvenne, J-C, Yaliraki, SN, Barahona, M

A major goal of dynamical systems theory is the search for simplified descriptions of the dynamics of a large number of interacting states. For overwhelmingly complex dynamical systems, the derivation of a reduced description on the entire dynamics a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::1fa67d2f6ced692dea71e51b9e62d6eb
http://hdl.handle.net/10044/1/80794

Prediction of Protein Allosteric Signalling Pathways and Functional Residues Through Paths of Optimised Propensity.

Autor: Wu N; Department of Chemistry Imperial College London, United Kingdom., Yaliraki SN; Department of Chemistry Imperial College London, United Kingdom., Barahona M; Department of Mathematics, Imperial College London, United Kingdom. Electronic address: m.barahona@imperial.ac.uk.

Publikováno v: Journal of molecular biology [J Mol Biol] 2022 Sep 15; Vol. 434 (17), pp. 167749. Date of Electronic Publication: 2022 Jul 14.

Proteins across scales through graph partitioning: application to the major peanut allergen Ara h 1

Autor: Zhang, H, Salazar, JD, Yaliraki, SN

The analysis of community structure in complex networks has been given much attention recently, as it is hoped that the communities at various scales can affect or explain the global behaviour of the system. A plethora of community detection algorith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::15f29e9f8dba124720fe0257ff4e71fa
http://hdl.handle.net/10044/1/51857

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.

Autor: Chrysostomou S; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Roy R; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Prischi F; School of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK.; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK., Thamlikitkul L; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Chapman KL; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.; Assay Biology, Domainex Ltd, Cambridge CB10 1XL, UK., Mufti U; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Peach R; Department of Chemistry, Imperial College London, London SW7 2AZ, UK.; Department of Neurology, University Hospital Würzburg, 97080 Würzburg, Germany., Ding L; Key Laboratory of Magnetic Resonance in Biological Systems, National Centre for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China., Hancock D; Oncogene Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Moore C; Oncogene Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Molina-Arcas M; Oncogene Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Mauri F; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Pinato DJ; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Abrahams JM; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Ottaviani S; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Castellano L; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Giamas G; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK., Pascoe J; Department of Oncology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK., Moonamale D; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK., Pirrie S; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham B15 2TT, UK., Gaunt C; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham B15 2TT, UK., Billingham L; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham B15 2TT, UK., Steven NM; Department of Oncology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK., Cullen M; Department of Oncology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK., Hrouda D; Department Urology, Charing Cross Hospital, London W6 8RF, UK., Winkler M; Department Urology, Charing Cross Hospital, London W6 8RF, UK., Post J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH. UK., Cohen P; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH. UK., Salpeter SJ; Curesponse, 6 Weizmann Street, 6423906 Tel Aviv, Israel., Bar V; Curesponse, 6 Weizmann Street, 6423906 Tel Aviv, Israel., Zundelevich A; Curesponse, 6 Weizmann Street, 6423906 Tel Aviv, Israel., Golan S; Department of Urology, Rabin Medical Center, Jabotinsky St. 39, 4941492 Petah Tikva, Israel., Leibovici D; Department of Urology, Kaplan Medical Center, 7610001 Rehovot, Israel., Lara R; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.; AstraZeneca, Discovery Science, R&D, Discovery Biology, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK., Klug DR; Department of Chemistry, Imperial College London, London SW7 2AZ, UK., Yaliraki SN; Department of Chemistry, Imperial College London, London SW7 2AZ, UK., Barahona M; Department of Mathematics, Imperial College London, London SW7 2AZ, UK., Wang Y; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore., Downward J; Oncogene Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Skehel JM; Biological Mass Spectrometry and Proteomics, MRC LMB, Cambridge CB2 0QH, UK., Ali MMU; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. maruf.ali@imperial.ac.uk m.seckl@imperial.ac.uk o.pardo@imperial.ac.uk., Seckl MJ; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. maruf.ali@imperial.ac.uk m.seckl@imperial.ac.uk o.pardo@imperial.ac.uk., Pardo OE; Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. maruf.ali@imperial.ac.uk m.seckl@imperial.ac.uk o.pardo@imperial.ac.uk.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Jul 14; Vol. 13 (602).