Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Autor: Haiyang Tang, PhD, Kang Wu, MD, PhD, Jian Wang, MD, Sujana Vinjamuri, MD, MS, Yali Gu, MS, RN, Shanshan Song, MD, PhD, Ziyi Wang, MD, Qian Zhang, MD, Angela Balistrieri, Ramon J. Ayon, PhD, Franz Rischard, MD, Rebecca Vanderpool, PhD, Jiwang Chen, PhD, Guofei Zhou, PhD, Ankit A. Desai, MD, Stephen M. Black, PhD, Joe G.N. Garcia, MD, Jason X.-J. Yuan, MD, PhD, Ayako Makino, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 744-762 (2018)

Summary: Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial h

Externí odkaz: https://doaj.org/article/7ab59fb0cf2a4a7e9cf3b59b50b2cd9f

The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension

Autor: Changlei Bao, Shuxin Liang, Ying Han, Zi Yang, Shiyun Liu, Yanan Sun, Shichuang Zheng, Yuzhu Li, Ting Wang, Yali Gu, Kang Wu, Stephen M. Black, Jian Wang, Steffan T. Nawrocki, Jennifer S. Carew, Jason X.-J. Yuan, Haiyang Tang

Publikováno v: Hypertension (Dallas, Tex. : 1979). 80(1)

Background: Autophagy plays an important role in the pathogenesis of pulmonary hypertension (PH). ROC-325 is a novel small molecule lysosomal autophagy inhibitor that has more potent anticancer activity than the antimalarial drug hydroxychloroquine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7a8e5ef20a6a8cf9d859c697330e47
https://pubmed.ncbi.nlm.nih.gov/36345832

Application of a Novel Aerobic Denitrifier for the Simultaneously Remove Nitrogen, Zinc and Bisphenol a from Wastewater

Autor: Pei Hong, Kai Zhang, Yue Dai, Calista N.T. Yuen, Yuxin Gao, Yali Gu, Kenneth Mei Yee Leung

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7341ab1a310f739dd5b9f4421f3c0e72
https://doi.org/10.2139/ssrn.4063545

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Autor: Ayako Makino, Ankit A. Desai, Ramon J. Ayon, Yali Gu, Ziyi Wang, Qian Zhang, Guofei Zhou, Shanshan Song, Franz Rischard, Jiwang Chen, Jason X.-J. Yuan, Kang Wu, Sujana Vinjamuri, Angela Balistrieri, Haiyang Tang, Rebecca Vanderpool, Joe G.N. Garcia, Jian Wang, Stephen M. Black

Publikováno v: JACC. Basic to translational science, vol 3, iss 6
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 744-762 (2018)

Visual Abstract
Highlights • G protein-coupled receptors and tyrosine kinase receptors signal through the phosphoinositide 3-kinase/Akt/mTOR pathway to induce cell proliferation, survival, and growth. mTOR is a kinase present in 2 functionally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1d147fc74d88a884f1e521e7ef3c53
https://doi.org/10.1016/j.jacbts.2018.08.009

Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension

Autor: Joe G.N. Garcia, Ramon J. Ayon, Xiongting Wu, Zhihao Liang, Christina Wang, Stephen M. Black, Yali Gu, Ziyi Wang, Jian Wang, Kimberly M. McDermott, Qian Zhang, Shanshan Song, Ayako Makino, Wenju Lu, Jason X.-J. Yuan, Angela Balistrieri, Haiyang Tang, Kang Wu

Publikováno v: British Journal of Pharmacology. 174:4155-4172

Background and Purpose Sustained pulmonary vasoconstriction and excessive pulmonary vascular remodelling are two major causes of elevated pulmonary vascular resistance in patients with pulmonary arterial hypertension. The purpose of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc53435013dbaa3a20f8cb6a2ccf51f9
https://doi.org/10.1111/bph.13990