Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Yale E, Goldman"'
Autor:
Michael C. Owens, Hui Shen, Amber Yanas, Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Xiaoyu Wei, Him Shweta, Hsin-Yao Tang, Yale E. Goldman, Kathy Fange Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mutations in the RNA helicase DDX3X, implicated in various cancers and neurodevelopmental disorders, often impair RNA unwinding and translation. However, the mechanisms underlying the impairment and the differential interactions of DDX3X mut
Externí odkaz:
https://doaj.org/article/8062689e8ce84829b39e1fe5a2eb1b50
Autor:
Shijie Huang, Arpan Bhattacharya, Mikel D. Ghelfi, Hong Li, Clark Fritsch, David M. Chenoweth, Yale E. Goldman, Barry S. Cooperman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Ataluren is the only nonsense suppressor drug currently approved for clinical use. Here, the authors determine where ataluren binds to the ribosome and how it inhibits termination at nonsense codons.
Externí odkaz:
https://doaj.org/article/52c6bd055f67489bb40a044bb577cd4f
Autor:
Aaron Snoberger, Bipasha Barua, Jennifer L Atherton, Henry Shuman, Eva Forgacs, Yale E Goldman, Donald A Winkelmann, E Michael Ostap
Publikováno v:
eLife, Vol 10 (2021)
Hypertrophic cardiomyopathies (HCMs) are the leading cause of acute cardiac failure in young individuals. Over 300 mutations throughout β-cardiac myosin, including in the motor domain, are associated with HCM. A β-cardiac myosin motor mutation (R71
Externí odkaz:
https://doaj.org/article/a7523ab1d3fc41fc9e768c62b8590538
Enhancing Nanoparticle Detection in Interferometric Scattering (iSCAT) Microscopy Using a Mask R-CNN
Publikováno v:
The Journal of Physical Chemistry B. 127:3737-3745
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71272a066c51c5e8972291b9276389e0
https://doi.org/10.1021/acs.jpcb.3c00097
https://doi.org/10.1021/acs.jpcb.3c00097
Autor:
Michael S. Woody, Michael J. Greenberg, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, E. Michael Ostap
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Omecamtiv mecarbil (OM) is a positive cardiac inotrope in clinical trials for the treatment of heart failure whose mechanism of action is incompletely understood. Here the authors show that OM inhibits myosin's working stroke and prolongs actomyosin
Externí odkaz:
https://doaj.org/article/a390d9a0840145559f69f13c5f0635e6
Publikováno v:
eLife, Vol 8 (2019)
Key steps of cardiac mechanochemistry, including the force-generating working stroke and the release of phosphate (Pi), occur rapidly after myosin-actin attachment. An ultra-high-speed optical trap enabled direct observation of the timing and amplitu
Externí odkaz:
https://doaj.org/article/7e6497584f8c4b5f9f10fe21aaa0176a
Autor:
Ryan M Jamiolkowski, Kevin Y Chen, Shane A Fiorenza, Alyssa M Tate, Shawn H Pfeil, Yale E Goldman
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222964 (2019)
In single molecule fluorescence studies, background emission from labeled substrates often restricts their concentrations to non-physiological nanomolar values. One approach to address this challenge is the use of zero-mode waveguides (ZMWs), nanosca
Externí odkaz:
https://doaj.org/article/e4b24f5c9dfe46599509e528b681fcf6
Autor:
Arpan Bhattacharya, Mikel D. Ghelfi, Xiaonan Cui, Clark Fritsch, Hong Li, Barry S. Cooperman, Yale E. Goldman
Publikováno v:
Biophysical Journal. 122:490a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c59422155ff3d69cedbfea8022541b9
https://doi.org/10.1016/j.bpj.2022.11.2618
https://doi.org/10.1016/j.bpj.2022.11.2618
Publikováno v:
Biophysical Journal. 122:437a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fb3329184341be2ee6125294d01defa
https://doi.org/10.1016/j.bpj.2022.11.2360
https://doi.org/10.1016/j.bpj.2022.11.2360
Publikováno v:
Biophysical Journal. 122:319a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3cb9bf4d6496212bc56ae69c1bf6afb
https://doi.org/10.1016/j.bpj.2022.11.1790
https://doi.org/10.1016/j.bpj.2022.11.1790