Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yalan Tu"'
Autor:
Yangyang Zhao, Yansong Dong, Shuhan Yang, Yalan Tu, Chengbo Wang, Jun Li, Youyong Yuan, Zhexiong Lian
Publikováno v:
ACS Central Science. 8:603-614
Adoptive cellular therapy utilizing chimeric antigen receptor redirected T (CAR-T) cells has shown impressive therapeutic effects on hematological malignancies. In contrast, the efficacy of CAR-T therapies in treating solid tumors is still poor, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2098df3af7dba0eccbb560743e4b3a
https://doi.org/10.1021/acscentsci.2c00163
https://doi.org/10.1021/acscentsci.2c00163
Publikováno v:
Science China Chemistry. 64:1020-1030
Determination of whether multidrug nanocarriers can deliver and release loaded drugs at a predefined synergistic ratio to target cancer cells is crucial. Although there are many successful applications for delivery of multiple drugs, most current car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88c59567c9e296f1039d34b80801cddd
https://doi.org/10.1007/s11426-020-9964-x
https://doi.org/10.1007/s11426-020-9964-x
Autor:
Yansong Dong, Wen-Jie Tang, Hui-Kang Yang, Shiwei Luo, Ruili Wei, Xinqing Jiang, Wang Yao, Youyong Yuan, Yalan Tu, Xinhua Wei, Wanli Zhang, Ruimeng Yang, Xinrui Pang
Publikováno v:
ACS Applied Materials & Interfaces. 13:14004-14014
Developing novel activatable photosensitizers with excellent plasma membrane targeting ability is urgently needed for smart photodynamic therapy (PDT). Herein, a tumor acidity-activatable photosensitizer combined with a two-step bioorthogonal pretarg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06207f89bfe0acd10ef597eb7cc5c084
https://doi.org/10.1021/acsami.1c01259
https://doi.org/10.1021/acsami.1c01259
Autor:
Xinqing Jiang, Xuan Xiao, Ruimeng Yang, Shiwei Luo, Youyong Yuan, Maolin Jiang, Yalan Tu, Fangzhou Yu, Wang Yao
Publikováno v:
Nano Letters. 21:2216-2223
The codelivery of drugs at specific optimal ratios to cancer cells is vital for combination chemotherapy. However, most of the current strategies are unable to coordinate the loading and release of drug combinations to acquire precise and controllabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b568a44d86768b1e2804ccb796255bd
https://doi.org/10.1021/acs.nanolett.0c05028
https://doi.org/10.1021/acs.nanolett.0c05028
Publikováno v:
Angewandte Chemie. 132:7235-7239
Prodrugs activated by endogenous stimuli face the problem of tumor heterogeneity. Bioorthogonal prodrug activation that utilizes an exogenous click reaction has the potential to solve this problem, but most of the strategies currently used rely on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4185440ae2e794a9ed7f938290e0bd99
https://doi.org/10.1002/ange.201913522
https://doi.org/10.1002/ange.201913522
Publikováno v:
Biomaterials. 289:121795
Although stimuli-responsive polymers have emerged as promising strategies for intelligent cancer therapy, limited polymer degradation and insufficient drug release remain a challenge. Here, we report a novel reactive oxygen species (ROS)-awakened sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c1df9a4d8c54678f01aee8c5bcb3b5
https://doi.org/10.1016/j.biomaterials.2022.121795
https://doi.org/10.1016/j.biomaterials.2022.121795
Publikováno v:
Biomaterials. 289:121803
Reactive oxygen species (ROS)-activated prodrugs can potentially improve the selectivity of chemotherapeutics. However, the inability to release sufficient drugs at tumor sites due to the paucity of ROS, which is required for prodrug activation usual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30afb7dacf5f4ce4765ee863946149a
https://doi.org/10.1016/j.biomaterials.2022.121803
https://doi.org/10.1016/j.biomaterials.2022.121803
Publikováno v:
Biomaterials. 278
Combination therapy using multiple drugs with time-programmed administration is promising for enhanced cancer treatment. However, it is still challenging to achieve time-programmed drug release from a single nanocarrier. Here, dual polyprodrugs of he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d29ff2470b6022d77f517c9dae2bad
https://pubmed.ncbi.nlm.nih.gov/34562835
https://pubmed.ncbi.nlm.nih.gov/34562835
Publikováno v:
Biomaterials. 270
High intracellular glutathione (GSH) levels play an important role in multidrug resistance (MDR) in cancer cells. It remains challenging to develop a drug delivery system that is simultaneously capable of GSH depletion and drug activation for multidr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0049be4ed55f70ff4eff6e5680c2ca
https://pubmed.ncbi.nlm.nih.gov/33588139
https://pubmed.ncbi.nlm.nih.gov/33588139
Autor:
Kewei Wang, Ruimeng Yang, Yalan Tu, Xinqing Jiang, Youyong Yuan, Qingyu Zong, Xuan Xiao, Wang Yao
Publikováno v:
ACS applied materialsinterfaces. 12(6)
The normoxic and hypoxic microenvironments in solid tumors cause cancer cells to show different sensitivities to various treatments. Therefore, it is essential to develop different therapeutic modalities based on the tumor microenvironment. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e43ca927752fde18a467db3f6ad2f3
https://pubmed.ncbi.nlm.nih.gov/31951372
https://pubmed.ncbi.nlm.nih.gov/31951372