Výsledky vyhledávání - "Yakov Rotshteyn"

Akademický článek

Novel small-molecule inhibitors of hepatitis C virus entry block viral spread and promote viral clearance in cell culture.

Autor: Glen A Coburn, Danielle N Fisch, Sameer M Moorji, Jean-Marc de Muys, Jose D Murga, Dorothy Paul, Kathleen P Provoncha, Yakov Rotshteyn, Amy Q Han, Dapeng Qian, Paul J Maddon, William C Olson

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35351 (2012)

Combinations of direct-acting anti-virals offer the potential to improve the efficacy, tolerability and duration of the current treatment regimen for hepatitis C virus (HCV) infection. Viral entry represents a distinct therapeutic target that has bee

Externí odkaz: https://doaj.org/article/a9586f6cd3614cdea54f6f4f8141f1da

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Methylnaltrexone bromide: research update of pharmacokinetics following parenteral administration

Autor: Yakov Rotshteyn, Thomas A Boyd, Chun-Su Yuan

Publikováno v: Expert Opinion on Drug Metabolism & Toxicology. 7:227-235

Opioid-induced constipation is a major side effect of the use of opioid pain medications in a palliative care population. At present, the only approved treatment for opioid-induced constipation is methylnaltrexone bromide subcutaneous injection. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491680a30f04645a956cf2990f877e76
https://doi.org/10.1517/17425255.2011.549824

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Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults

Autor: Paul D'Ambrosio, Melanie A. Thompson, Paul J. Maddon, Nancy Stambler, Barry S. Zingman, Michael S. Saag, Jeffrey M. Jacobson, Jacob Lalezari, Stephen A. Morris, Yakov Rotshteyn, William C. Olson, Carl J. Fichtenbaum, Andre Marozsan

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:4137-4142

The anti-CCR5 antibody PRO 140 has shown potent and prolonged antiretroviral activity in subjects infected with CCR5-tropic (R5) HIV-1. Prior studies have examined single intravenous doses ranging up to 5 mg/kg of body weight or up to three subcutane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5766dbd239084d2759e2290bf3c70194
https://doi.org/10.1128/aac.00086-10

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Antiviral Activity of Single‐Dose PRO 140, a CCR5 Monoclonal Antibody, in HIV‐Infected Adults

Publikováno v: The Journal of Infectious Diseases. 198:1345-1352

Background The current goal of human immunodeficiency virus type 1 (HIV-1) therapy is to maximally suppress viral replication. Securing this goal requires new drugs and treatment classes. The chemokine receptor CCR5 provides an entry portal for HIV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747c451b72e8501332e838f138a0dba5
https://doi.org/10.1086/592169

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DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat

Autor: Kenneth J. Valenzano, Scott Nolan, Yakov Rotshteyn, Sam Victory, Shen Shan, Kevin Christopher Brogle, Donald J. Kyle, Ellen Davies, Jincheng Huang, Nezima Allie, Gregg Crumley, Wendy S. Miller, Zhengming Chen

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 310:793-799

Mu opioid receptors are expressed throughout the central and peripheral nervous systems. Peripheral inflammation leads to an increase in mu receptor present on the peripheral terminals of primary sensory neurons. Activation of peripheral mu receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7485d49ff5391bf2671e60c5a7ee873
https://doi.org/10.1124/jpet.103.063560

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DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systemically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: I. In Vitro Pharmacological Characterization and Pharmacokinetic Properties

Autor: Kenneth J, Valenzano, Wendy, Miller, Zhengming, Chen, Shen, Shan, Gregg, Crumley, Sam F, Victory, Ellen, Davies, Jin-Cheng, Huang, Nezima, Allie, Scott J, Nolan, Yakov, Rotshteyn, Donald J, Kyle, Kevin, Broglé

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 310:783-792

Mu opioid receptors are present throughout the central and peripheral nervous systems. Peripheral inflammation causes an increase in mu receptor levels on peripheral terminals of primary afferent neurons. Recent studies indicate that activation of pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbf73bf642af1980003ca5b87df0e6f
https://doi.org/10.1124/jpet.103.063313

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A Highly Sensitive Assay for the Simultaneous Determination of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Human Plasma by High-Performance Liquid Chromatography with Electrochemical and

Autor: Brianne Weingarten, Yakov Rotshteyn

Publikováno v: Therapeutic Drug Monitoring. 18:179-188

Summary A novel, highly sensitive and specific bioanalytical method has been developed for the simultaneous determination of morphine and its major metabolites, morphine-3-glucuronide and morphine-6-glucuronide, in human plasma, using noroxymorphone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faa5d9ab9a31409a0d7eb47b8a0f5f2a
https://doi.org/10.1097/00007691-199604000-00012

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Novel small-molecule inhibitors of hepatitis C virus entry block viral spread and promote viral clearance in cell culture

Autor: Jose D. Murga, Kathleen Provoncha, Yakov Rotshteyn, Sameer M. Moorji, William C. Olson, D. Paul, Jean-Marc de Muys, Amy Han, Danielle N. Fisch, Dapeng Qian, Paul J. Maddon, Glen A. Coburn

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35351 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1ce627cbf9f4a54b49d87810732f13
http://europepmc.org/articles/PMC3335862?pdf=render

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Anti-HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibody

Autor: Stephen A. Morris, Paul J. Maddon, Nancy Stambler, Paul D'Ambrosio, Yakov Rotshteyn, Michael S. Saag, Jacob Lalezari, Melanie A. Thompson, William C. Olson, Barry S. Zingman, Andre Marozsan, Jeffrey M. Jacobson

Publikováno v: The Journal of infectious diseases. 201(10)

PRO 140 is a humanized CCR5 monoclonal antibody that has demonstrated potent antiviral activity when it is administered intravenously to adults infected with CCR5-tropic (R5) human immunodeficiency virus type 1 (HIV-1). This study is the first to eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e90749e8a2b26df988ce950c31dbf28
https://pubmed.ncbi.nlm.nih.gov/21170687

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In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexone

Autor: Yakov Rotshteyn, Appavu Chandrasekaran, John C. L. Erve, Rasmy Talaat, JoAnn Scatina, William DeMaio, Zeen Tong, Theresa Hultin, Hongshan Li

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 38(5)

Methylnaltrexone (MNTX) is a peripherally acting mu-opioid receptor antagonist and is currently indicated for the treatment of opioid-induced constipation in patients with advanced illness who are receiving palliative care, when response to laxative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1d75d1437503f301030778587c453f
https://pubmed.ncbi.nlm.nih.gov/20173089

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