Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yakov M. Koen"'
Publikováno v:
Toxicological Sciences. 135:390-401
Many low molecular weight compounds undergo biotransformation to chemically reactive metabolites (CRMs) that covalently modify cellular proteins. However, the mechanisms by which this covalent binding leads to cytotoxicity are not understood. Prior a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26042fa68b9fc754e776043d46e83398
https://doi.org/10.1093/toxsci/kft166
https://doi.org/10.1093/toxsci/kft166
Autor:
Robert P. Hanzlik, Heather Hajovsky, Yakov M. Koen, Todd D. Williams, Jeff L. Staudinger, Nadezhda A. Galeva, Diganta Sarma
Publikováno v:
Chemical Research in Toxicology. 26:564-574
Thioacetamide (TA) has long been known as a hepatotoxicant whose bioactivation requires S-oxidation to thioacetamide S-oxide (TASO) and then to the very reactive S,S-dioxide (TASO2). The latter can tautomerize to form acylating species capable of cov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca21accd776b046b8e6b3f625ea2f0f
https://doi.org/10.1021/tx400001x
https://doi.org/10.1021/tx400001x
Publikováno v:
Chemical research in toxicology. 29(11)
The hepatotoxicity of acetaminophen (APAP) is generally attributed to the formation of a reactive quinoneimine metabolite (NAPQI) that depletes glutathione and covalently binds to hepatocellular proteins. To explore the importance of the N-acyl group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a91758b1bebb8fd96f46eaa4614b90
https://pubmed.ncbi.nlm.nih.gov/27680534
https://pubmed.ncbi.nlm.nih.gov/27680534
Publikováno v:
Chemical research in toxicology. 29(6)
Isoniazid (INH) has been a first-line drug for the treatment of tuberculosis for more than 40 years. INH is well-tolerated by most patients, but some patients develop hepatitis that can be severe in rare cases or after overdose. The mechanisms underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd397d4e87be61ff5adf08d10464456a
https://pubmed.ncbi.nlm.nih.gov/27097313
https://pubmed.ncbi.nlm.nih.gov/27097313
Autor:
Diganta Sarma, David S. Moore, Gang Hu, Robert P. Hanzlik, Wenqi Cui, Jeff L. Staudinger, Yakov M. Koen, Heather Hajovsky
Publikováno v:
Chemical Research in Toxicology. 25:1955-1963
The hepatotoxicity of thioacetamide (TA) has been known since 1948. In rats, single doses cause centrolobular necrosis accompanied by increases in plasma transaminases and bilirubin. To elicit these effects, TA requires oxidative bioactivation, leadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bfdfd3d5cf264103adc7f876b8edeb
https://doi.org/10.1021/tx3002719
https://doi.org/10.1021/tx3002719
Autor:
Robert P. Hanzlik, Diganta Sarma, Todd D. Williams, Jeff L. Staudinger, Heather Hajovsky, Yakov M. Koen, Nadezhda A. Galeva
Publikováno v:
Chemical Research in Toxicology. 25:1868-1877
Thioacetamide (TA) is a well-known hepatotoxin in rats. Acute doses cause centrilobular necrosis and hyperbilirubinemia while chronic administration leads to biliary hyperplasia and cholangiocarcinoma. Its acute toxicity requires its oxidation to a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae5c3ceef73effa71226118eb2a86d2
https://doi.org/10.1021/tx3001658
https://doi.org/10.1021/tx3001658
Autor:
Kelin Li, James S. Leeder, Jennifer L. Goldman, Yakov M. Koen, Steven A. Rogers, Robert P. Hanzlik
The formation of drug-protein adducts via metabolic activation and covalent binding may stimulate an immune response or may result in direct cell toxicity. Protein covalent binding is a potentially pivotal step in the development of idiosyncratic adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f438025b348d444e72e148ce115055
Autor:
Yakov M. Koen, Tao Ji, Steven Wynn Esch, Todd D. Williams, Robert P. Hanzlik, Keisuke Ikehata
Publikováno v:
Chemical Research in Toxicology. 20:701-708
Thiobenzamide (TB) is hepatotoxic in rats causing centrolobular necrosis, steatosis, cholestasis and hyperbilirubinemia. It serves as a model compound for a number of thiocarbonyl compounds that undergo oxidative bioactivation to chemically reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471a11bec199d32384f57773572875ae
https://doi.org/10.1021/tx600362h
https://doi.org/10.1021/tx600362h
Publikováno v:
Chemical Research in Toxicology. 19:1426-1434
The hepatotoxicity of bromobenzene (BB) derives from its reactive metabolites (epoxides and quinones), which arylate cellular proteins. Application of proteomic methods to liver proteins from rats treated with a hepatotoxic dose of [ 14 C]-BB has ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b0933fd403a0493d24cb870f5aac0e
https://doi.org/10.1021/tx060142s
https://doi.org/10.1021/tx060142s
Publikováno v:
Chemical Research in Toxicology. 18:1748-1754
The cytotoxicity of many small organic compounds often apparently derives from their metabolic activation and covalent binding to cellular proteins. It is therefore of considerable interest to be able to determine, for a given protoxin, which metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081d887e8f3e708f0db4e621a42ea4ab
https://doi.org/10.1021/tx050199z
https://doi.org/10.1021/tx050199z