Výsledky vyhledávání - "Yakov Gluzman"

A Herpes Simplex Virus Type 1 γ34.5 Second-Site Suppressor Mutant That Exhibits Enhanced Growth in Cultured Glioblastoma Cells Is Severely Attenuated in Animals

Autor: Ian Mohr, Matthew Mulvey, David A. Leib, Yakov Gluzman, David Sternberg, Stephen L. Ward

Publikováno v: Journal of Virology. 75:5189-5196

We describe here the neurovirulence properties of a herpes simplex virus type 1 γ34.5 second-site suppressor mutant. γ34.5 mutants are nonneurovirulent in animals and fail to grow in a variety of cultured cells due to a block at the level of protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b47aa14f401f1332b202649e3828393
https://doi.org/10.1128/jvi.75.11.5189-5196.2001

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Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin

Autor: Larocque James Paul, Yakov Gluzman, Stanley A. Lang, Mary Bradley, Ramaswamy Nilakantan, Martin Joseph Digrandi, Bloom Jonathan David, Morin John Edward, Bryan Mark O'hara, Olga Palant, Stephen J. Plotch

Publikováno v: Journal of Virology. 73:140-151

Several compounds that specifically inhibited replication of the H1 and H2 subtypes of influenza virus type A were identified by screening a chemical library for antiviral activity. In single-cycle infections, the compounds inhibited virus-specific p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b2077b272ca0ac8883faf7aecf5c0e
https://doi.org/10.1128/jvi.73.1.140-151.1999

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Inhibition of Human Cytomegalovirus UL80 Protease by Specific Intramolecular Disulfide Bond Formation

Autor: Marshall M. Siegel, John Nygaard, Ellen Z. Baum, Latha Sridharan, Lei Sun, Yakov Gluzman, Keiko Tabei, Thomas R. Jones, Stuart H. Johnston, Jeffrey D. Hulmes, Geraldine Bebernitz, Mary Jo Wildey

Publikováno v: Biochemistry. 35:5838-5846

A symmetrically substituted disulfide compound, CL13933, was identified as a potent inhibitor of human cytomegalovirus UL80 protease. Two types of inhibited protease were observed, depending on inh...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae099256a5ffc81e9a76df7dd63c88ed
https://doi.org/10.1021/bi952996+

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Flavins Inhibit Human Cytomegalovirus UL80 Protease via Disulfide Bond Formation

Autor: Jeff Hulmes, George A. Ellestad, Geraldine Bebernitz, and Andrew P. Seddon, Martin Joseph Digrandi, Yakov Gluzman, Bloom Jonathan David, Girija Krishnamurthy, Ellen Z. Baum, Marshall M. Siegel, Tommaso Carofiglio, Mary Bradley, John T. Groves, Weidong Ding, Keiko Tabei, Latha Sridharan

Publikováno v: Biochemistry. 35:5847-5855

Among the most potent inhibitors of human cytomegalovirus protease identified by random screening of a chemical library was 1,4-dihydro-7,8-dimethyl 6H-pyrimido[1,2-b]-1,2,4,5-tetrazin-6-one (1) (PTH2). The oxidized form (2), PT, which is present in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78a66be6c8770aa5a7ea64746b44c8b
https://doi.org/10.1021/bi9529972

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Escherichia coli chromosomal mutations that permit direct cloning of the Bacteroides fragiiis metallo-?-lactamase gene, ccrA

Autor: F. P. Tally, B. A. Rasmussen, Yakov Gluzman

Publikováno v: Molecular Microbiology. 5:1211-1219

Summary The class B, metallo-β-lactamase genes ccrA (carbapenem- and cephamycin resistance) from three Bacteroides fragilis isolates — QMCN3, QMCN4, and TAL3636 — were cloned and expressed in Escherichia coli. Cloning of the genes, by selecting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07d7bb9a558fd81b182701e0d0fc651
https://doi.org/10.1111/j.1365-2958.1991.tb01895.x

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Cloning, Characterization and Developmental Regulation of Two Members of a Novel Human Gene Family of Neurite Outgrowth-Promoting Proteins

Autor: Mildred Decker, Yakov Gluzman, Peter J. Kretschmer, Christine P. Chan, Peter Bohlen, Jeanette L. Fairhurst, Imre Kovesdi

Publikováno v: Growth Factors. 5:99-114

This report describes the cloning, expression and characterization of two members of a novel human gene family of proteins, HBNF and MK, which exhibit neurite outgrowth-promoting activity. The HBNF cDNA gene codes for a 168-residue protein which is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fa04f7197fc0e89d905dd6b47717e9
https://doi.org/10.3109/08977199109000275

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beta-Galactosidase containing a human immunodeficiency virus protease cleavage site is cleaved and inactivated by human immunodeficiency virus protease

Autor: Geraldine Bebernitz, Ellen Z. Baum, Yakov Gluzman

Publikováno v: Proceedings of the National Academy of Sciences. 87:10023-10027

A "cleavage cassette" specifying a decapeptide human immunodeficiency virus (HIV) protease cleavage site was introduced into six different locations of beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) in Escherichia coli. Four of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c679ac7f9ebd7795c003dc67c6b86226
https://doi.org/10.1073/pnas.87.24.10023

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Exogenous thymidine is preferentially incorporated into human cytomegalovirus DNA in infected human fibroblasts

Autor: O'hara Bryan Mark, S V Johann, Yakov Gluzman, Morin John Edward

Publikováno v: Journal of Virology. 70:6402-6404

The effect of human cytomegalovirus infection on cellular DNA synthesis in human fibroblasts was measured by fluorometry and by incorporation of radiolabeled thymidine. The results show that although HCMV infection stimulates cellular DNA synthesis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb779dd72d463cb9fa9347943abd5c6
https://doi.org/10.1128/jvi.70.9.6402-6404.1996

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