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Akademický článek

Multiplexed on-yeast serological assay for immune escape screening of SARS-CoV-2 variants

Autor: Joanan Lopez-Morales, Rosario Vanella, Tamara Utzinger, Valentin Schittny, Julia Hirsiger, Michael Osthoff, Christoph T. Berger, Yakir Guri, Michael A. Nash

Publikováno v: iScience, Vol 26, Iss 5, Pp 106648- (2023)

Summary: The emergence of the SARS-CoV-2 Omicron variant altered patient risk profiles and shifted the trajectory of the COVID-19 pandemic. Therefore, sensitive serological tests capable of analyzing patient IgG responses to multiple variants in para

Externí odkaz: https://doaj.org/article/acba1905787e4d8683cc950f4cf31e66

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Akademický článek

Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development

Autor: Dalya Ataca, Marian Caikovski, Alessandra Piersigilli, Alexandre Moulin, Charaf Benarafa, Sarah E. Earp, Yakir Guri, Corinne Kostic, Yvan Arsenivic, Raija Soininen, Suneel S. Apte, Cathrin Brisken

Publikováno v: Biology Open, Vol 5, Iss 11, Pp 1585-1594 (2016)

The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular matrix components and have diverse functions in numerous disease and physiological contexts. A number of them remain ‘orphan’ proteases and among them is ADAMTS1

Externí odkaz: https://doaj.org/article/864fa76dacce443db8a7cb36e25536c8

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Akademický článek

mTOR at the Transmitting and Receiving Ends in Tumor Immunity

Autor: Yakir Guri, Thierry M. Nordmann, Jason Roszik

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Cancer is a complex disease and a leading cause of death worldwide. Immunity is critical for cancer control. Cancer cells exhibit high mutational rates and therefore altered self or neo-antigens, eliciting an immune response to promote tumor eradicat

Externí odkaz: https://doaj.org/article/1550510a6cc9405fb84d5cb9d2767706

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Rapidly Adaptable Multiplexed Yeast Surface Display Serological Assay for Immune Escape Screening of SARS-CoV-2 Variants

Autor: Joanan Lopez-Morales, Rosario Vanella, Tamara Utzinger, Valentin Schittny, Julia Hirsiger, Michael Osthoff, Christoph Berger, Yakir Guri, Michael A. Nash

With numerous variations in the Spike protein, including concentrated mutations in the receptor-binding domain (RBD), the SARS-CoV-2 Omicron variant significantly shifted in the trajectory of the COVID-19 pandemic. To understand individual patient ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96e0f8a2abf93206a424e2f0540e3654
https://doi.org/10.1101/2023.02.17.23286074

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Structural basis for regulation of human acetyl-CoA carboxylase

Autor: Edward Stuttfeld, Timm Maier, Anna Hagmann, Yakir Guri, Henning Stahlberg, Mohamed Chami, Moritz Hunkeler

Publikováno v: Nature. 558:470-474

Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis1,2. Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3782c70be3b50df5f2cbeea03fc24360
https://doi.org/10.1038/s41586-018-0201-4

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The protein histidine phosphatase LHPP is a tumour suppressor

Autor: Charlotte K.Y. Ng, Dritan Liko, Paul Jenoe, Michael N. Hall, Charles Betz, Tony Hunter, Yakir Guri, Markus H. Heim, Luigi Terracciano, Sravanth K. Hindupur, Marco Colombi, Matthias S. Matter, Salvatore Piscuoglio, Stephen Rush Fuhs, Luca Quagliata, Suzette Moes, Marion Cornu, Kevin Adam

Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized post-translational modification of proteins1,2. Here we describe a role of histidine phosphorylation in tumorigenesis. Proteomic analysis of 12 tumours from an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f6092cd0a2c4742a98882b4d878852
https://edoc.unibas.ch/62663/

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mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Autor: Suzette Moes, Isabelle Riezman, Sravanth K. Hindupur, Yakir Guri, Marco Colombi, Jason Roszik, Howard Riezman, Markus H. Heim, Paul Jenoe, Michael N. Hall, Eva Dazert

Publikováno v: Cancer Cell, Vol. 32, No 6 (2017) pp. 807-823.e12

Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94f0b31f418cb7af022622ecde2a92e
https://archive-ouverte.unige.ch/unige:142351

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Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development

Autor: Marian Caikovski, Corinne Kostic, Yvan Arsenivic, Cathrin Brisken, Yakir Guri, Charaf Benarafa, Sarah E. Earp, Dalya Ataca, Alexandre Moulin, Alessandra Piersigilli, Raija Soininen, Suneel S. Apte

Publikováno v: Ataca, Dalya; Caikovski, Marian; Piersigilli, Alessandra; Moulin, Alexandre; Benarafa, Charaf; Earp, Sarah E; Guri, Yakir; Kostic, Corinne; Arsenijvic, Yvan; Soininen, Raija; Apte, Suneel S; Brisken, Cathrin (2016). Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development. Biology open BiO, 5(11), pp. 1585-1594. Company of Biologists 10.1242/bio.019711
Biology open, vol. 5, no. 11, pp. 1585-1594
Biology Open, Vol 5, Iss 11, Pp 1585-1594 (2016)
Biology open
Biology Open

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8794a3fe1e4105cf6d50c7722cea6aea
https://boris.unibe.ch/95402/1/1585.full.pdf

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T-cell synapse formation depends on antigen recognition but not CD3 interaction: Studies with TCR:zeta, a candidate transgene for TCR gene therapy

Autor: Yakir Guri, Janos Roszik, Zsuzsanna Pályi-Krekk, Péter Nagy, Reno Debets, Zsolt Sebestyén, Arpad Szoor, Coen Govers, János Szöllosi, György Vereb

Publikováno v: European Journal of Immunology, 41(5), 1288-1297. Wiley-VCH

T-cell receptors (TCRs) can be genetically modified to improve gene-engineered T-cell responses, a strategy considered critical for the success of clinical TCR gene therapy to treat cancers. TCR:zeta, which is a heterodimer of TCR alpha and beta chai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a44074d077e6855f78cf05b12a4188
https://doi.org/10.1002/eji.200940233

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Cover Picture: Eur. J. Immunol. 5/11

Autor: Janos Roszik, Reno Debets, Péter Nagy, György Vereb, Zsolt Sebestyén, Yakir Guri, Coen Govers, János Szöllősi, Zsuzsanna Pályi-Krekk, Árpád Szöőr

Publikováno v: European Journal of Immunology. 41

The cover image of this issue consists of a confocal microscopic FRET image showing immunological synapse formation in Jurkat T cells, and is taken from Roszik et al. (pp. 1288–1297). In this article, the authors characterize TCR-ζ, a heterodimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60030ae0a85f0bfbba09e0eab62636f6
https://doi.org/10.1002/eji.201190027

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