Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Yajing Rong"'
Autor:
Laura Belanger, Limei Zhang, Maria L. Webb, Yajing Rong, Quynhchi Pham, Steven G. Kultgen, Susan M. Parlato, Andrew Laird Roughton, Tiffany L. Walker, Yan Xu, Michael Ohlmeyer, Bing Hu, Koc-Kan Ho, Anthony E. Klon, David A. Dunn, Darcey Black, Peter C. Ray, James R. Beasley, Jane Wright, Jui-Hsiang Chan, Kai Xu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6027-6031
The profile of a series of triazine and pyrimidine based ROCK inhibitors is described. An initial binding mode was established based on a homology model and the proposed interactions are consistent with the observed SAR. Compounds from the series are
Autor:
Maria L. Webb, Jeffrey J. Letourneau, Michael Ohlmeyer, Hong Li, Biji Jacob, Jinqi Liu, Kenneth C. Appell, Angela Wong, Shalini Bansal, Chris Riviello, Yajing Rong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:352-355
The discovery, synthesis and preliminary SAR of a novel class of non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5) is described. High-throughput screening of an extensive series of ECLiPStrade mark compound librar
Autor:
Martin-Jan Smit, Jac C. H. M. Wijkmans, Rong-Qiang Liu, Jaap van der Louw, Koc-Kan Ho, Jim Inglese, Shawn David Erickson, Ming You, Ellen Son, Andrew Laird Roughton, Douglas S. Auld, G.M.T. Vogel, Christopher M. Masterson, Paolo Conti, Daming Feng, Martijn Rooseboom, Adolph Bohnstedt, Celia Kingsbury, Maria L. Webb, Steven G. Kultgen, Yajing Rong, Michael Ohlmeyer, Philippe Samama, Wim Dokter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2724-2728
An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected
Autor:
Yajing Rong, Arnold E. Ruoho
Publikováno v:
Synthetic Communications. 29:2155-2162
In the present work a short and convenient route for the synthesis of salmeterol from salicylaldehyde has been developed.
Autor:
Lynn Abernethy, Quynhchi Pham, Helen Feilden, Olaf Nimz, Yajing Rong, Michael Ohlmeyer, Anna-Marie Easson, David A. Dunn, Heather Tracey, Littlewood Peter Thomas Albert, Steve Kultgen, Lesley-Anne Nisbet, John Maclean, Maureen Dempster, Duncan McArthur, Robert Swanson, Melanie Sammons, Ronnie Palin, Andrew Laird Roughton, Darren Edwards, Kenneth S. Cameron, Deborah McGregor, Paul Ratcliffe, Irina Neagu, Hazel McLuskey, Koc-Kan Ho, Katy Everett, Thomas R. Clarkson, Glenn Walker, Nasrin Ansari
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(15)
Systematic optimisation of a poorly soluble lead series of isoxazole-3-carboxamides was conducted. Substitution of the 4-position with specific polar functionality afforded the requisite balance of potency, solubility and physicochemical properties.
Autor:
Michael Ohlmeyer, Yajing Rong, Katy Everett, Robert Swanson, Nasrin Ansari, Duncan McArthur, Kenneth S. Cameron, Quynhchi Pham, Irina Neagu, Heather Tracey, Darren Edwards, John Maclean, Maureen Dempster, Thomas R. Clarkson, Hazel McLuskey, Koc-Kan Ho, Helen Feilden, Paul Ratcliffe, David A. Dunn, Andrew Laird Roughton, S.A. Neale, Steve Kultgen, Glenn Walker, Littlewood Peter Thomas Albert, Melanie Sammons, Ronald Palin, Lynn Abernethy, Anna-Marie Easson, Deborah McGregor, Lesley-Anne Nisbet
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(3)
Optimisation of a screening hit incorporating both TRPV1 activity and solubility was conducted. Substitution of the isoxazole-3-carboxamide with the bespoke 1S, 3R-3-aminocyclohexanol motif afforded the requisite balance of potency and solubility. Co
Autor:
Yajing Rong, Arnold E. Ruoho
Publikováno v:
ChemInform. 30
In the present work a short and convenient route for the synthesis of salmeterol from salicylaldehyde has been developed.
Autor:
Jeffrey J, Letourneau, Jinqi, Liu, Michael H J, Ohlmeyer, Chris, Riviello, Yajing, Rong, Hong, Li, Kenneth C, Appell, Shalini, Bansal, Biji, Jacob, Angela, Wong, Maria L, Webb
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(2)
The discovery, synthesis and preliminary SAR of a novel class of non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5) is described. High-throughput screening of an extensive series of ECLiPStrade mark compound librar
Autor:
Zhengfeng Zhou, Sridharan Rajamani, Yajing Rong, Shetuan Zhang, Craig T. January, Arnold E. Ruoho, Yuenmu Chen, Qiuming Gong
Publikováno v:
Molecular pharmacology. 59(5)
Cocaine causes cardiac arrhythmias, sudden death, and occasionally long QT syndrome in humans. We investigated the effect of cocaine on the human K(+) channels HERG and KvLQT1+minK that encode native rapidly (I(Kr)) and slowly (I(Ks)) activating dela