Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yajing Lyu"'
Autor:
Yajing Lyu, Yongkang Yang, Varen Talwar, Haiquan Lu, Chelsey Chen, Shaima Salman, Elizabeth E. Wicks, Tina Yi-Ting Huang, Daiana Drehmer, Yufeng Wang, Qiaozhu Zuo, Emmanuel Datan, Walter Jackson, III, Dominic Dordai, Ru Wang, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113972- (2024)
Summary: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates cellular adaptation to decreased oxygen availability. HIF-1 recruits chromatin-modifying enzymes leading to changes in histone acetylation, citrullination, and m
Externí odkaz:
https://doaj.org/article/81c1beb3ca954c18aaff5e6ff94c9e4a
Autor:
Yuqian Zhang, Hehuan Li, Yanting Shen, Shunxi Wang, Lei Tian, Haoqiang Yin, Jiawei Shi, Anqi Xing, Jinghua Zhang, Usman Ali, Abdul Sami, Xueyan Chen, Chenxuan Gao, Yangtao Zhao, Yajing Lyu, Xiaoxu Wang, Yanhui Chen, Zhixi Tian, Shu-Biao Wu, Liuji Wu
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113723- (2024)
Summary: Stop codon readthrough (SCR) has important biological implications but remains largely uncharacterized. Here, we identify 1,009 SCR events in plants using a proteogenomic strategy. Plant SCR candidates tend to have shorter transcript lengths
Externí odkaz:
https://doaj.org/article/e87282f267644cfb97779168a79f8ed8
Autor:
Qiaozhu Zuo, Yongkang Yang, Yajing Lyu, Chen Yang, Chelsey Chen, Shaima Salman, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, III, Emmanuel Datan, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112164- (2023)
Summary: Intratumoral hypoxia is a microenvironmental feature that promotes breast cancer progression and is associated with cancer mortality. Plexin B3 (PLXNB3) is highly expressed in estrogen receptor-negative breast cancer, but the underlying mech
Externí odkaz:
https://doaj.org/article/33aaf8ed82ef405fa617b1722f2239c3
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that modulates target gene expression in response to changes in oxygen availability. Here the authors show that HIF-1 forms a complex with TRIM28 and DNA-dependent protein kinase (DNA-PK) t
Externí odkaz:
https://doaj.org/article/34b58a895ed248ba90fef65625529862
Publikováno v:
Chinese Medicine and Natural Products, Vol 02, Iss 03, Pp e120-e130 (2022)
The classified prescriptions from Chaihu decoction have been widely used in ancient and modern times. In spite of many previous research studies, the extensiveness and diversity of their applications have not been systematically studied. The author a
Externí odkaz:
https://doaj.org/article/0d4d09317a7b4986b9c00d2a403c29cf
Autor:
Shaima Salman, David J. Meyers, Elizabeth E. Wicks, Sophia N. Lee, Emmanuel Datan, Aline M. Thomas, Nicole M. Anders, Yousang Hwang, Yajing Lyu, Yongkang Yang, Walter Jackson III, Dominic Dordai, Michelle A. Rudek, Gregg L. Semenza
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and available therapies, including immunotherapies, are ineffective for many patients. HCC is characterized by intratumoral hypoxia, and increased expression of hypoxia-ind
Externí odkaz:
https://doaj.org/article/93de6172546f4b1dba403323cea12053
Autor:
Pengyue Wang, Jianjian Liu, Yajing Lyu, Ziting Huang, Xiaoli Zhang, Bingjian Sun, Pengbai Li, Xinxin Jing, Honglian Li, Chao Zhang
Publikováno v:
Viruses, Vol 14, Iss 10, p 2258 (2022)
Rice (Oryza sativa L.) is one of the major staple foods for global consumption. A major roadblock to global rice production is persistent loss of crops caused by plant diseases, including rice blast, sheath blight, bacterial blight, and particularly
Externí odkaz:
https://doaj.org/article/0579738d96794954bca2d3049e324053
Autor:
Haiquan Lu, Yajing Lyu, Linh Tran, Jie Lan, Yangyiran Xie, Yongkang Yang, Naveena L. Murugan, Yueyang J. Wang, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109757- (2021)
Summary: Breast cancer stem cells (BCSCs) play essential roles in tumor formation, drug resistance, relapse, and metastasis. NANOG is a protein required for stem cell self-renewal, but the mechanisms by which it performs this function are poorly unde
Externí odkaz:
https://doaj.org/article/6923e8f5594f476ea3b6fc24e190a811
Autor:
Yuqian Zhang, Hehuan Li, Yanting Shen, Shunxi Wang, Lei Tian, Haoqiang Yin, Jiawei Shi, Anqi Xing, Jinghua Zhang, Usman Ali, Abdul Sami, Xueyan Chen, Chenxuan Gao, Yangtao Zhao, Yajing Lyu, Xiaoxu Wang, Yanhui Chen, Zhixi Tian, Shu-Biao Wu, Liuji Wu
Stop codon readthrough (SCR), the decoding of a stop codon as a sense codon by the ribosome, has important biological implications but remains largely uncharacterized in plants. Here, we identified 1,009 SCR events in two monocots (maize, rice) and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8221a134898203aa69d760f734c45d4d
https://doi.org/10.1101/2023.03.20.533458
https://doi.org/10.1101/2023.03.20.533458
Autor:
Yongkang Yang, Chelsey Chen, Qiaozhu Zuo, Haiquan Lu, Shaima Salman, Yajing Lyu, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, Emmanuel Datan, Ru Wang, Yufeng Wang, Nguyet Le, Yayun Zhu, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Science Advances. 8
Hypoxia is a key characteristic of the breast cancer microenvironment that promotes expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1) and is associated with poor patient outcome. HIF-1 increases the expression or activity