Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Yajie GUO"'
Autor:
Xixi Hou, Longfei Mao, Yajie Guo, Lan Wang, Lizeng Peng, Huili Wang, Jianxue Yang, Sanqiang Li, Yue-Ming Li
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract Modification of marketed drugs is an important way to develop drugs because its safety and clinical applicability. Oxygen-nitrogen heterocycles are a class of important active substances discovered in the process of new drug development. Dol
Externí odkaz:
https://doaj.org/article/d66191b3ae3d4647be1e806383cfcfa9
Autor:
Bing Zhao, Huiwen Zheng, Juliano Timm, Zexuan Song, Shaojun Pei, Ruida Xing, Yajie Guo, Ling Ma, Feina Li, Qing Li, Yan Li, Lin Huang, Chong Teng, Ni Wang, Aastha Gupta, Sandeep Juneja, Fei Huang, Yanlin Zhao, Xichao Ou
Publikováno v:
Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-8 (2024)
Abstract Background Pretomanid is a key component of new regimens for the treatment of drug-resistant tuberculosis (TB) which are being rolled out globally. However, there is limited information on the prevalence of pre-existing resistance to the dru
Externí odkaz:
https://doaj.org/article/f32ac678040f425d9287824b09a6c9e3
Autor:
Huiwen Zheng, Jing Xiao, Feina Li, Hao Chen, Deze Li, Yonghong Wang, Yajie Guo, Yuying Chen, Chen Shen
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Interferon-gamma release assay (IGRA) is the main tool for the diagnosis of latent tuberculosis (TB) infection (LTBI). However, the indeterminate results were more frequent in children, and the underlying reasons were largely spec
Externí odkaz:
https://doaj.org/article/edfdeb2bcb574405972a755b7aade14b
Publikováno v:
Nanomaterials, Vol 14, Iss 15, p 1260 (2024)
The carbon nanotube cold cathode has important applications in the X-ray source, microwave tube, neutralizer, etc. In this study, the characteristics of carbon nanotube (CNT) electron gun in series with metal-oxide-semiconductor field-effect transist
Externí odkaz:
https://doaj.org/article/0b03dd5cde8e4d4dafed55a494d1ee27
Autor:
Huiwen Zheng, Haiming Yang, Yonghong Wang, Feina Li, Jing Xiao, Yajie Guo, Hao Chen, Xiaotong Wang, Huimin Li, Chen Shen
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23217- (2024)
Objectives: To evaluate the diagnostic value of targeted next generation sequencing (tNGS) in childhood tuberculosis (TB) and compare the accuracy with Xpert MTB/RIF method. Methods: Children aged ≤18 years with symptoms suggestive of TB during Jul
Externí odkaz:
https://doaj.org/article/8da21363eb564b3f98443fff8f51efb8
Publikováno v:
环境与职业医学, Vol 40, Iss 5, Pp 500-507 (2023)
BackgroundDue to the limited availability of established research models, very few studies addressed the health effects and underlying mechanisms following exposure to diesel exhaust during the initiation of pulmonary respiration. It is highly demand
Externí odkaz:
https://doaj.org/article/ba52cc1a826544659312e736e8b8df48
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Hitherto, the recognition of the microbiota role in tumorigenesis and clinical studies mostly focused on the intestinal flora. In contrast to the gut microbiome, microorganisms resident in tumor tissue are in close contact with cancer cells
Externí odkaz:
https://doaj.org/article/5d22c2b6055e4ab6ae2e97b2676866c6
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Procedural myocardial injury (PMI), which is the most common complication of elective percutaneous coronary intervention (ePCI), is associated with future adverse cardiac events. In this randomized pilot trial, we assessed the effects of pro
Externí odkaz:
https://doaj.org/article/eac02536330f4e9a8ce0a5ef243a8a02
Publikováno v:
Molecules, Vol 29, Iss 8, p 1779 (2024)
We introduced a terminal alkyne into the core structure of dolutegravir, resulting in the synthesis of 34 novel dolutegravir-1,2,3-triazole compounds through click chemistry. These compounds exhibited remarkable inhibitory activities against two hepa
Externí odkaz:
https://doaj.org/article/6ed4ca75a6ee4c5cbaabc879b27756ad
Autor:
Yajie Guo, Dan Sang, Bin Guo, Dan Wang, Xinyue Xu, Huili Wang, Cuilan Hou, Longfei Mao, Fang Li, Sanqiang Li
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
In pursuit of discovering novel anticancer agents, we designed and synthesized a series of novel 1,2,3-triazole hybrids based on cabotegravir analogues. These compounds were subjected to initial biological evaluations to assess their anticancer activ
Externí odkaz:
https://doaj.org/article/912eaaa5f7f34d8a871cdc581a076c60