Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yajamana Ramu"'
Publikováno v:
eLife, Vol 11 (2022)
ATP-sensitive K+ (KATP) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secr
Externí odkaz:
https://doaj.org/article/11a4f7b8d0a745f1a7853228250ae526
Publikováno v:
eLife, Vol 3 (2014)
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause recurring bacterial infection in CF patients' lungs. However, the severity of CF lung disease correlates poorly with genotype. Antibiotic treatment helps dramatically p
Externí odkaz:
https://doaj.org/article/9e2369f01f6644cf8de43af53b33d3ca
ATP-sensitive K+ (KATP) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1d9d9c279b8a5ae91dfce35460e322
https://doi.org/10.1101/2022.01.16.476512
https://doi.org/10.1101/2022.01.16.476512
Autor:
Yajamana Ramu, Zhe Lu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
Inhibitors targeting ion channels are useful tools for studying their functions. Given the selectivity of any inhibitor for a channel is relative, more than one inhibitor of different affinities may be used to help identify the channel in a biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34db34b3cd1676e8176b20257ca519de
http://link.springer.com/article/10.1038/s41598-019-50688-x
http://link.springer.com/article/10.1038/s41598-019-50688-x
Publikováno v:
The Journal of General Physiology
Mutations in ATP-sensitive K+ channels can cause permanent neonatal diabetes mellitus, and patients with some mutations become practically insensitive to the common antidiabetic drug sulphonylurea. Ramu et al. identify a 54-residue protein (SpTx-1) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8492240bf757c9cfb599ddcb1d2e49
https://doi.org/10.1085/jgp.201812017
https://doi.org/10.1085/jgp.201812017
Publikováno v:
Nature Structural & Molecular Biology. 24:857-865
C-type inactivation underlies important roles played by voltage-gated K+ (Kv) channels. Functional studies have provided strong evidence that a common underlying cause of this type of inactivation is an alteration near the extracellular end of the ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d4cfaac09e80e6c70d639c88adbad0f
https://doi.org/10.1038/nsmb.3457
https://doi.org/10.1038/nsmb.3457
Publikováno v:
Nature structural & molecular biology
Voltage-gated ion channels underlie rapid electric signaling in excitable cells. Electrophysiological studies have established that the N-terminal half of the fourth transmembrane segment ((NT)S4) of these channels is the primary voltage sensor, wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fe55364c8e14b27d28bbaea63ad47a
http://europepmc.org/articles/PMC3777420
http://europepmc.org/articles/PMC3777420
Publikováno v:
Proceedings of the National Academy of Sciences. 105:10774-10778
Inward-rectifier K + (Kir) channels play many important biological roles and are emerging as important therapeutic targets. Subtype-specific inhibitors would be useful tools for studying the channels' physiological functions. Unfortunately, available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b526141a0340fb016e155b9b58077f5c
https://doi.org/10.1073/pnas.0802850105
https://doi.org/10.1073/pnas.0802850105
Publikováno v:
Nature. 451:826-829
A fundamental question regarding the gating mechanism of voltage-activated K+ (Kv) channels is how five positively charged voltage-sensing residues in the fourth transmembrane (TM) segment1, 2 are energetically stabilized, as they operate in a low-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b686c6fb71662d86de9d537b9005cbd
https://doi.org/10.1038/nature06618
https://doi.org/10.1038/nature06618