Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yajaira Suarez"'
Autor:
Victoria Ulrich, Noemi Rotllan, Elisa Araldi, Amelia Luciano, Philipp Skroblin, Mélanie Abonnenc, Paola Perrotta, Xiaoke Yin, Ashley Bauer, Kristen L Leslie, Pei Zhang, Binod Aryal, Rusty L Montgomery, Thomas Thum, Kathleen Martin, Yajaira Suarez, Manuel Mayr, Carlos Fernandez‐Hernando, William C Sessa
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 6, Pp 643-653 (2016)
Abstract Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chron
Externí odkaz:
https://doaj.org/article/dfae49429d474f239ee09a30e0002d2d
Autor:
Nathan L. Price, Pablo Fernández-Tussy, Luis Varela, Magdalena P. Cardelo, Marya Shanabrough, Binod Aryal, Rafael de Cabo, Yajaira Suárez, Tamas L. Horvath, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in
Externí odkaz:
https://doaj.org/article/f1a854edd40041bf8676f1f698ab6e77
Autor:
Inmaculada Ruz-Maldonado, John T. Gonzalez, Hanming Zhang, Jonathan Sun, Alicia Bort, Inamul Kabir, Richard G. Kibbey, Yajaira Suárez, Daniel M. Greif, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Midlobular hepatocytes are proposed to be the most plastic hepatic cell, providing a reservoir for hepatocyte proliferation during homeostasis and regeneration. However, other mechanisms beyond hyperplasia have been little explored and the c
Externí odkaz:
https://doaj.org/article/464ecf555656487594404e7c594fa8c7
Autor:
Balkrishna Chaube, Kathryn M. Citrin, Mahnaz Sahraei, Abhishek K. Singh, Diego Saenz de Urturi, Wen Ding, Richard W. Pierce, Raaisa Raaisa, Rebecca Cardone, Richard Kibbey, Carlos Fernández-Hernando, Yajaira Suárez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic homeostasis remains to be elucidated. Here, using endothelial-speci
Externí odkaz:
https://doaj.org/article/6020962f83424a44a099256c33013ee0
Autor:
Elisa Araldi, Aranzazu Chamorro-Jorganes, Coen Solingen, Carlos Fernandez-Hernando, Yajaira Suarez
Publikováno v:
Current Vascular Pharmacology. 13:291-304
Atherosclerosis (also known as arteriosclerotic vascular disease) is a chronic inflammatory disease of the arterial wall, characterized by the formation of lipid-laden lesions. The activation of endothelial cells at atherosclerotic lesion-prone sites
Autor:
Francesca Bosetti, Zorina S. Galis, Margaret S. Bynoe, Marc Charette, Marilyn J. Cipolla, Gregory J. del Zoppo, Douglas Gould, Thomas S. Hatsukami, Teresa L. Z. Jones, James I. Koenig, Gerard A. Lutty, Christine Maric‐Bilkan, Troy Stevens, H. Eser Tolunay, Walter Koroshetz, Dritan Agalliu, David A. Antonetti, Manfred Boehm, Claudette E. Brooks, Kathleen M. Caron, William Chilian, Mat J. Daemen, Robert D'Amato, Thomas P. Davis, Adviye Ergul, James E. Faber, Ariel R. Gomez, Peter Grayson, Isabella Grumbach, Jaime Grutzendler, Chenghua Gu, David Gutterman, John Hallenbeck, Ira Herman, Jay Humphrey, Costantino Iadecola, Edward W. Inscho, David Kleinfeld, Eng H. Lo, Jose A. Lopez, Stephen Macknik, Asrar Malik, Tanya N. Mayadas, Dorian McGavern, Gerald A. Meininger, Virginia M. Miller, Maiken Nedergaard, Mark T. Nelson, Shayn Peirce‐Cottler, Ipolia Ramadan, Gary A. Rosenberg, Ernesto L. Schiffrin, Peter Searson, Nina Stachenfeld, Radu V. Stan, Yajaira Suarez, Eroboghene E. Ubogu, Zinaida S. Vexler, Cornelia M. Weyand, Berislav V. Zlokovic
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, 5(11). Wiley-Blackwell
Journal of the American Heart Association, 5(11). Wiley-Blackwell
Small blood vessels (generally
Autor:
Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, Balkrishna Chaube, Bonne M. Thompson, Richard G. Lee, Gary W. Cline, Jeffrey G. McDonald, Gerald I. Shulman, Miguel A. Lasunción, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and chol
Externí odkaz:
https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c
Autor:
Noemi Rotllan, Xinbo Zhang, Alberto Canfrán-Duque, Leigh Goedeke, Raquel Griñán, Cristina M. Ramírez, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113419- (2022)
Objective: miR-148a-3p (miR-148a) is a hepatic and immune-enriched microRNA (miRNA) that regulates macrophage-related lipoprotein metabolism, cholesterol homeostasis, and inflammation. The contribution of miR-148a-3p to the progression of atheroscler
Externí odkaz:
https://doaj.org/article/2ef32137959041b0bd54a61fb1582ef7
Autor:
Katey J Rayner, Frederick J Sheedy, Christine Esau, Farah N Hussain, Ryan E Temel, Saj Parathath, Janine van Gils, Alistair Rayner, Aaron Chang, Yajaira Suarez, Carlos Fernandez-Hernando, Edward A Fisher, Kathryn J Moore
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32
Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise HDL and exploit its atheroprotective effects have remained elusive. Recent studies identified miR-33 as an intronic microRNA, located within the SREBF2 gene,
Autor:
Jun Yu, Carlos Fernandez-Hernando, Yajaira Suarez, Michael Schleicher, Zhengrong Hao, Paulette L Wright, Themis R Kyriakides, William C Sessa
Publikováno v:
Circulation. 118
Nogo-B, a member of the reticulon 4 family of proteins, is the dominant isoform expressed in endothelial, vascular smooth muscle and inflammatory cells. We previously have shown Nogo-B plays a critical role in vascular remodeling after injury in vivo