Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Yajaira, Suárez"'
Autor:
Nathan L. Price, Pablo Fernández-Tussy, Luis Varela, Magdalena P. Cardelo, Marya Shanabrough, Binod Aryal, Rafael de Cabo, Yajaira Suárez, Tamas L. Horvath, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in
Externí odkaz:
https://doaj.org/article/f1a854edd40041bf8676f1f698ab6e77
Autor:
Inmaculada Ruz-Maldonado, John T. Gonzalez, Hanming Zhang, Jonathan Sun, Alicia Bort, Inamul Kabir, Richard G. Kibbey, Yajaira Suárez, Daniel M. Greif, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Midlobular hepatocytes are proposed to be the most plastic hepatic cell, providing a reservoir for hepatocyte proliferation during homeostasis and regeneration. However, other mechanisms beyond hyperplasia have been little explored and the c
Externí odkaz:
https://doaj.org/article/464ecf555656487594404e7c594fa8c7
Autor:
Balkrishna Chaube, Kathryn M. Citrin, Mahnaz Sahraei, Abhishek K. Singh, Diego Saenz de Urturi, Wen Ding, Richard W. Pierce, Raaisa Raaisa, Rebecca Cardone, Richard Kibbey, Carlos Fernández-Hernando, Yajaira Suárez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic homeostasis remains to be elucidated. Here, using endothelial-speci
Externí odkaz:
https://doaj.org/article/6020962f83424a44a099256c33013ee0
Autor:
Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, Balkrishna Chaube, Bonne M. Thompson, Richard G. Lee, Gary W. Cline, Jeffrey G. McDonald, Gerald I. Shulman, Miguel A. Lasunción, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and chol
Externí odkaz:
https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-14 (2021)
Abstract miRNAs have emerged as critical regulators of nearly all biologic processes and important therapeutic targets for numerous diseases. However, despite the tremendous progress that has been made in this field, many misconceptions remain among
Externí odkaz:
https://doaj.org/article/f9de2e4064ff4f6b9075aa00a4d61d3c
Autor:
Xinbo Zhang, Jonathan Sun, Alberto Canfrán-Duque, Binod Aryal, George Tellides, Ying Ju Chang, Yajaira Suárez, Timothy F. Osborne, Carlos Fernández-Hernando
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Epigenetic modifications of the genome, including DNA methylation, histone methylation/acetylation, and noncoding RNAs, have been reported to play a fundamental role in regulating immune response during the progression of atherosclerosis. SETDB2 is a
Externí odkaz:
https://doaj.org/article/a3e168e7b1064f7b99f145e8a9e45c58
Autor:
Seungjin Ryu, Irina Shchukina, Yun-Hee Youm, Hua Qing, Brandon Hilliard, Tamara Dlugos, Xinbo Zhang, Yuki Yasumoto, Carmen J Booth, Carlos Fernández-Hernando, Yajaira Suárez, Kamal Khanna, Tamas L Horvath, Marcelo O Dietrich, Maxim Artyomov, Andrew Wang, Vishwa Deep Dixit
Publikováno v:
eLife, Vol 10 (2021)
Increasing age is the strongest predictor of risk of COVID-19 severity and mortality. Immunometabolic switch from glycolysis to ketolysis protects against inflammatory damage and influenza infection in adults. To investigate how age compromises defen
Externí odkaz:
https://doaj.org/article/101f9b85da2743c6bb111871bfca2ee2
Autor:
Abhishek K. Singh, Binod Aryal, Balkrishna Chaube, Noemi Rotllan, Luis Varela, Tamas L. Horvath, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 59-69 (2018)
Objectives: Brown adipose tissue (BAT) controls triglyceride-rich lipoprotein (TRL) catabolism. This process is mediated by the lipoprotein lipase (LPL), an enzyme that catalyzed the hydrolysis of triglyceride (TAG) in glycerol and fatty acids (FA),
Externí odkaz:
https://doaj.org/article/5e28d6f791074ddbaf00aad1320938a9
Autor:
Nathan L. Price, Abhishek K. Singh, Noemi Rotllan, Leigh Goedeke, Allison Wing, Alberto Canfrán-Duque, Alberto Diaz-Ruiz, Elisa Araldi, Ángel Baldán, Joao-Paulo Camporez, Yajaira Suárez, Matthew S. Rodeheffer, Gerald I. Shulman, Rafael de Cabo, Carlos Fernández-Hernando
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2133-2145 (2018)
Summary: While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovas
Externí odkaz:
https://doaj.org/article/e344e7cdc5634e7db68d175d5c1581a0
Autor:
Nathan L. Price, Noemi Rotllan, Alberto Canfrán-Duque, Xinbo Zhang, Paramita Pati, Noemi Arias, Jack Moen, Manuel Mayr, David A. Ford, Ángel Baldán, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1317-1330 (2017)
Summary: As an important regulator of macrophage cholesterol efflux and HDL biogenesis, miR-33 is a promising target for treatment of atherosclerosis, and numerous studies demonstrate that inhibition of miR-33 increases HDL levels and reduces plaque
Externí odkaz:
https://doaj.org/article/6a44b423eeff4a9487df7bcc4da530ff