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pro vyhledávání: '"Yair Klieger"'
Publikováno v:
Cytometry Part B: Clinical Cytometry. 94:211-218
Background: Quantitative flow cytometry (QFCM) can be an important element within the developing toolbox for clinical diagnostics which relies on precise and rapid tests that provide a conclusive answer for physicians. The FC technology combines all
Autor:
Michal Baniyash, Eliran Ish-Shalom, Julia Kanterman, Moshe Sade-Feldman, Olga Mizrahi, Yaron Meirow, Lynn Wang, Yair Klieger
Publikováno v:
The Journal of Immunology. 196:156-167
Chronic inflammation is associated with immunosuppression and downregulated expression of the TCR CD247. In searching for new biomarkers that could validate the impaired host immune status under chronic inflammatory conditions, we discovered that sor
Autor:
Yair Klieger, Inna Varfolomeev, Moshe Sade-Feldman, Ilan Vaknin, Camil Fuchs, Roy Eldor, Michal Baniyash
Publikováno v:
Diabetes Care. 38:113-118
OBJECTIVE We have previously shown that chronic inflammation results in immunosuppression associated with CD247 downregulation in T lymphocytes. Type 2 diabetes mellitus (T2DM) is known to be associated with chronic inflammation. We therefore sought
Autor:
Maor H. Pauker, Eliran Ish-Shalom, Osnat Almogi-Hazan, Lynn Wang, Michal Baniyash, Mira Barda-Saad, Yair Klieger, Aviad Pato
Publikováno v:
European Journal of Immunology. 44:58-68
TCR-mediated activation induces receptor microclusters that evolve to a defined immune synapse (IS). Many studies showed that actin polymerization and remodeling, which create a scaffold critical to IS formation and stabilization, are TCR mediated. H
Publikováno v:
Cytometry. Part B, Clinical cytometry. 94(2)
Quantitative flow cytometry (QFCM) can be an important element within the developing toolbox for clinical diagnostics which relies on precise and rapid tests that provide a conclusive answer for physicians. The FC technology combines all of these fea
Autor:
Francesca Levi-Schaffer, Yair Klieger, Ofer Mandelboim, Stipan Jonjić, Hrvoje Šimić, Dikla Lankry
Publikováno v:
The Journal of Immunology. 185:2877-2886
The killing activity of NK cells is regulated by signals derived from inhibitory and activating NK cell receptors, including the CD300 family of proteins. CD300a was reported to be expressed on all NK cells and to deliver an inhibitory signal upon bi
Autor:
Hani Shtainberg, Moshe Sade-Feldman, Michal Lotem, Yair Klieger, Michal Baniyash, Mizrahi Olga, Amijai Saragovi, Julia Kanterman, Eliran Ish-Shalom
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(23)
Purpose: High levels of circulating myeloid-derived suppressor cells (MDSCs) in various cancer types, including melanoma, were shown to correlate with poor survival. We investigated whether frequencies of circulating CD33+CD11b+HLA-DR− MDSCs could
Autor:
Yair Klieger, Ofer Yizhar, Margriet Snoek, Giora Simchen, Drora Zenvirth, Neta Shtepel-Milman
Publikováno v:
Molecular Biology of the Cell. 16:1449-1455
Yeast artificial chromosomes (YACs) that contain human DNA backbone undergo DNA double-strand breaks (DSBs) and recombination during yeast meiosis at rates similar to the yeast native chromosomes. Surprisingly, YACs containing DNA covering a recombin
Autor:
Yair, Klieger, Osnat, Almogi-Hazan, Eliran, Ish-Shalom, Aviad, Pato, Maor H, Pauker, Mira, Barda-Saad, Lynn, Wang, Michal, Baniyash
Publikováno v:
European journal of immunology. 44(1)
TCR-mediated activation induces receptor microclusters that evolve to a defined immune synapse (IS). Many studies showed that actin polymerization and remodeling, which create a scaffold critical to IS formation and stabilization, are TCR mediated. H
Publikováno v:
The Journal of Immunology. 186:113.24-113.24
Cytoskeleton rearrangement initiated upon specific T cell-antigen presenting cell (APC) interactions, is required for immunological synapse (IS) formation/maintenance, T cell activation and polar cytokine secretion. Following activation, most T cell