Reduced signal for polygenic adaptation of height in UK Biobank

Autor: Jeremy J Berg, Arbel Harpak, Nasa Sinnott-Armstrong, Anja Moltke Joergensen, Hakhamanesh Mostafavi, Yair Field, Evan August Boyle, Xinjun Zhang, Fernando Racimo, Jonathan K Pritchard, Graham Coop

Publikováno v: eLife, Vol 8 (2019)

Several recent papers have reported strong signals of selection on European polygenic height scores. These analyses used height effect estimates from the GIANT consortium and replication studies. Here, we describe a new analysis based on the the UK B

Externí odkaz: https://doaj.org/article/ab49c7c9474e42549524c281c71f19e5

Distinct modes of regulation by chromatin encoded through nucleosome positioning signals.

Autor: Yair Field, Noam Kaplan, Yvonne Fondufe-Mittendorf, Irene K Moore, Eilon Sharon, Yaniv Lubling, Jonathan Widom, Eran Segal

Publikováno v: PLoS Computational Biology, Vol 4, Iss 11, p e1000216 (2008)

The detailed positions of nucleosomes profoundly impact gene regulation and are partly encoded by the genomic DNA sequence. However, less is known about the functional consequences of this encoding. Here, we address this question using a genome-wide

Externí odkaz: https://doaj.org/article/4286c90cb20c4b2985c00ad5b6fcf04c

Reduced signal for polygenic adaptation of height in UK Biobank

Autor: Evan A. Boyle, Yair Field, Anja Moltke Joergensen, Hakhamanesh Mostafavi, Jonathan K. Pritchard, Arbel Harpak, Fernando Racimo, Graham Coop, Nasa Sinnott-Armstrong, Xinjun Zhang, Jeremy J. Berg

Publikováno v: eLife, Vol 8 (2019)
eLife
Berg, J J, Harpak, A, Sinnott-Armstrong, N, Jørgensen, A M, Mostafavi, H, Field, Y, Boyle, E A, Zhang, X, Racimo, F, Pritchard, J K & Coop, G 2019, ' Reduced signal for polygenic adaptation of height in UK Biobank ', eLife, vol. 8, e39725 . https://doi.org/10.7554/eLife.39725

There is considerable variation in average height across European populations, with individuals in the northwest being taller, on average, than those in the southeast. During the past six years, a series of papers reported that polygenic scores for h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851d422d4d0fedb13936da4c78ad5755
https://escholarship.org/uc/item/2bq0m1f2

Detection of human adaptation during the past 2000 years

Autor: Kyle J. Gaulton, Mark I. McCarthy, Ziyue Gao, David E. Golan, Loic Yengo, Jonathan K. Pritchard, Ghislain Rocheleau, Natalie Telis, Philippe Froguel, Evan A. Boyle, Yair Field

Publikováno v: Science (New York, N.Y.), vol 354, iss 6313
PMC

Detection of recent natural selection is a challenging problem in population genetics. Here we introduce the singleton density score (SDS), a method to infer very recent changes in allele frequencies from contemporary genome sequences. Applied to dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd8f443e7d2c42e7b150ee69ed9919f
https://pubmed.ncbi.nlm.nih.gov/29094708

The DNA-encoded nucleosome organization of a eukaryotic genome

Autor: Eran Segal, Timothy P. Hughes, Yvonne N. Fondufe-Mittendorf, Andrea J. Gossett, Emily M LeProust, Yair Field, Noam Kaplan, Irene K. Moore, Jason D. Lieb, Desiree Tillo, Jonathan Widom

Publikováno v: Nature. 458:362-366

The nucleosomes are the basic repeating units of eukaryotic chromatin, and nucleosome organization is critically important for gene regulation. Kaplan et al. tested the importance of the intrinsic DNA sequence preferences of nucleosomes by measuring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5165f7c70a97f13c3137397414a2d83
https://doi.org/10.1038/nature07667