Studying SARS-CoV-2 interactions using phage-displayed receptor binding domain as a model protein

Autor: Beatriz Pérez-Massón, Yazmina Quintana-Pérez, Yaima Tundidor, Dayana Pérez-Martínez, Camila Castro-Martínez, Mario Pupo-Meriño, Ivette Orosa, Ernesto Relova-Hernández, Rosmery Villegas, Osmany Guirola, Gertrudis Rojas

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract SARS-CoV-2 receptor binding domain (RBD) mediates viral entry into human cells through its interaction with angiotensin converting enzyme 2 (ACE2). Most neutralizing antibodies elicited by infection or vaccination target this domain. Such a

Externí odkaz: https://doaj.org/article/5fb8da803ded4e869e1bc185a4ff61c6

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A COVID-19 vaccine candidate composed of SARS-CoV-2 RBD dimer and Neisseria meningitidis outer membrane vesicles

Autor: Darielys Santana-Mederos, Rocmira Perez-Nicado, Yanet Climent, Laura Rodriguez, Belinda Sanchez Ramirez, Sonia Perez-Rodriguez, Meybi Rodriguez, Claudia Labrada, Tays Hernandez, Marianniz Diaz, Ivette Orosa, Ubel Ramirez, Reynaldo Oliva, Raine Garrido, Felix Cardoso, Mario Landys, Roselyn Martinez, Humberto Gonzalez, Tamara Hernandez, Rolando Ochoa-Azze, Jose L. Perez, Juliet Enriquez, Nibaldo Gonzalez, Yenicet Infante, Luis A. Espinosa, Yassel Ramos, Luis Javier González, Carmen Valenzuela, Ana Victoria Casadesus, Briandy Fernandez, Gertrudis Rojas, Beatriz Pérez-Massón, Yaima Tundidor, Ernesto Bermudez, Claudia A. Plasencia, Tammy Boggiano, Eduardo Ojito, Fabrizio Chiodo, Sonsire Fernandez, Françoise Paquet, Cheng Fang, Guang-Wu Chen, Daniel G. Rivera, Yury Valdes-Balbin, Dagmar Garcia-Rivera, Vicente Verez Bencomo

Publikováno v: RSC Chemical Biology
RSC Chemical Biology, Royal Society of Chemistry, In press, ⟨10.1039/D1CB00200G⟩
Santana-Mederos, D, Perez-Nicado, R, Climent, Y, Rodriguez, L, Ramirez, B S, Perez-Rodriguez, S, Rodriguez, M, Labrada, C, Hernandez, T, Diaz, M, Orosa, I, Ramirez, U, Oliva, R, Garrido, R, Cardoso, F, Landys, M, Martinez, R, Gonzalez, H, Hernandez, T, Ochoa-Azze, R, Perez, J L, Enriquez, J, Gonzalez, N, Infante, Y, Espinosa, L A, Ramos, Y, González, L J, Valenzuela, C, Casadesus, A V, Fernandez, B, Rojas, G, Pérez-Massón, B, Tundidor, Y, Bermudez, E, Plasencia, C A, Boggiano, T, Ojito, E, Chiodo, F, Fernandez, S, Garcia-Rivera, D, Fang, C, Chen, G-W, Rivera, D G, Valdes-Balbin, Y, Garcia-Rivera, D & Verez Bencomo, V 2022, ' A COVID-19 vaccine candidate composed of the SARS-CoV-2 RBD dimer and : Neisseria meningitidis outer membrane vesicles ', RSC Chemical Biology, vol. 3, no. 2, pp. 242-249 . https://doi.org/10.1039/d1cb00200g
RSC Chemical Biology, 3(2), 242-249. Royal Society of Chemistry

SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host's cellular receptor. Vaccines seek to block this interaction by eliciting neutralizing antibodies, most of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ca97b53fb4a278f7101794d646b985
https://hal.archives-ouvertes.fr/hal-03519898

Directed evolution of super-secreted variants from phage-displayed human Interleukin-2

Autor: Jorge Fernandez de Cossio-Diaz, Yaima Tundidor, Marlies Becker, Annia Pérez-Riverón, Pedro A. Valiente, Kalet León, Tania Carmenate, Julio Felipe Santo-Tomás, Luis Graca, Gertrudis Rojas, Yaquelín Ortiz, Stefan Dübel

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)

Selection from a phage display library derived from human Interleukin-2 (IL-2) yielded mutated variants with greatly enhanced display levels of the functional cytokine on filamentous phages. Introduction of a single amino acid replacement selected th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f2334e40c23669da947cc4219e8d94
http://europepmc.org/articles/PMC6349883

Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor

Autor: Amaury Pupo, Claudia Patricia García-Hernández, Yaima Tundidor, Gertrudis Rojas, Yanelys Cabrera Infante

Publikováno v: mAbs. 6(4)

Molecular details of epidermal growth factor receptor (EGFR) targeting by nimotuzumab, a therapeutic anti-cancer antibody, have been largely unknown. The current study delineated a functional map of their interface, based on phage display and extensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2730aca4bc67a5cb1e06340665b421b3
https://pubmed.ncbi.nlm.nih.gov/24759767