Zobrazeno 1 - 10 of 114 pro vyhledávání: '"Yaichiro, Kotake"'
1
Akademický článek
Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder
Autor: Ami Oguro, Taichi Fujiyama, Yasuhiro Ishihara, Chisato Kataoka, Megumi Yamamoto, Komyo Eto, Yoshihiro Komohara, Susumu Imaoka, Toshihide Sakuragi, Mayumi Tsuji, Eiji Shibata, Yaichiro Kotake, Takeshi Yamazaki
Publikováno v: Journal of Lipid Research, Vol 64, Iss 11, Pp 100458- (2023)
Although pregnant women’s fish consumption is beneficial for the brain development of the fetus due to the DHA in fish, seafood also contains methylmercury (MeHg), which adversely affects fetal brain development. Epidemiological studies suggest tha
Externí odkaz: https://doaj.org/article/e92ba8be57fa4b2ea88b871630551256
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2
Akademický článek
Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers
Autor: Kosuke Yoshida, Yuki Doi, Norihiko Iwazaki, Hidenori Yasuhara, Yuka Ikenaga, Hidetoshi Shimizu, Tomohisa Nakada, Tomoko Watanabe, Chise Tateno, Seigo Sanoh, Yaichiro Kotake
Publikováno v: Clinical and Translational Science, Vol 15, Iss 1, Pp 79-91 (2022)
Abstract Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokineti
Externí odkaz: https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
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6
Trehalose decreases mRNA and protein expressions of c-Jun and JunB in human cervical cancer HeLa cells
Autor: Kanae, Umeda-Miyara, Masatsugu, Miyara, Seigo, Sanoh, Yaichiro, Kotake
Publikováno v: The Journal of Biochemistry. 172:177-187
Increasing evidence suggests that trehalose, a non-reducing disaccharide, ameliorates disease phenotypes by activating autophagy in animal models of various human diseases, including neurodegenerative diseases. Multiple in vitro studies suggest that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4848d9542a370c2bca26160d0f1f46
https://doi.org/10.1093/jb/mvac051
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8
Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers
Autor: Yuki Doi, Hidetoshi Shimizu, Hidenori Yasuhara, Seigo Sanoh, Tomoko Watanabe, Norihiko Iwazaki, Yaichiro Kotake, Chise Tateno, Yuka Ikenaga, Kosuke Yoshida, Tomohisa Nakada
Publikováno v: Clinical and Translational Science, Vol 15, Iss 1, Pp 79-91 (2022)
Clinical and Translational Science
Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokinetics of suc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7637d6231eb9d24c530715918ca2fe2e
https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
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10
Akademický článek
Development of a simple measurement method for GluR2 protein expression as an index of neuronal vulnerability
Autor: Chihiro Sugiyama, Yaichiro Kotake, Masafumi Yamaguchi, Kanae Umeda, Yumi Tsuyama, Seigo Sanoh, Katsuhiro Okuda, Shigeru Ohta
Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 450-460 (2015)
In vitro estimating strategies for potential neurotoxicity are required to screen multiple substances. In a previous study, we showed that exposure to low-concentrations of some chemicals, such as organotin, decreased the expression of GluR2 protein,
Externí odkaz: https://doaj.org/article/119d3130a7834828b08cd92865156cb2
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