Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Yahli Lorch"'
Publikováno v:
Nucleic Acids Research. 51:3671-3678
The exceptionally high positive charge of the histones, concentrated in the N- and C-terminal tails, is believed to contribute to the stability of the nucleosome by neutralizing the negative charge of the nucleosomal DNA. We find, on the contrary, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e1498e2a82a3df6db6646c7207a247b
https://doi.org/10.1093/nar/gkad079
https://doi.org/10.1093/nar/gkad079
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
Small molecules that bind in the minor groove of DNA are in clinical use as antibiotics and antitumor drugs. Two members of this class of molecules, netropsin and chromomycin, are shown here to displace DNA from the nucleosome and promote transfer of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c75b7a70f8fd9f54e14b740235e957
https://pubmed.ncbi.nlm.nih.gov/36574674
https://pubmed.ncbi.nlm.nih.gov/36574674
Autor:
Roger D. Kornberg, Yahli Lorch
Publikováno v:
Molecular cell. 79(3)
Whereas the core nucleosome is thought to serve as a packaging device for the coiling and contraction in length of genomic DNA, we suggest that it serves primarily in the regulation of transcription. A nucleosome on a promoter prevents the initiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f401b72283c11746c9556b7fd43d2c
https://pubmed.ncbi.nlm.nih.gov/32763226
https://pubmed.ncbi.nlm.nih.gov/32763226
Summary The +1 nucleosome of yeast genes, within which reside transcription start sites, is characterized by histone acetylation, by the displacement of an H2A-H2B dimer, and by a persistent association with the RSC chromatin-remodeling complex. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4040eb052ece13beb1cf381ad05dc1
https://europepmc.org/articles/PMC6290470/
https://europepmc.org/articles/PMC6290470/
Autor:
Roger D. Kornberg, Yahli Lorch
Publikováno v:
Quarterly Reviews of Biophysics. 48:465-470
The nucleosome serves as a general gene repressor by the occlusion of regulatory and promoter DNA sequences. Repression is relieved by the SWI/SNF-RSC family of chromatin-remodeling complexes. Research reviewed here has revealed the essential feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b3193bea046da8aa73e6a2296e703c
https://doi.org/10.1017/s0033583515000116
https://doi.org/10.1017/s0033583515000116
Autor:
Roger D. Kornberg, Yahli Lorch
Publikováno v:
Quarterly Reviews of Biophysics. 50
The nucleosome serves as a general gene repressor, preventing all initiation of transcription except that which is brought about by specific positive regulatory mechanisms. The positive mechanisms begin with chromatin-remodeling by complexes that sli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3055fac6f6f03923909fee4f5a394e
https://doi.org/10.1017/s003358351700004x
https://doi.org/10.1017/s003358351700004x
Publikováno v:
Nature structural & molecular biology
Purified chromatin rings, excised from the PHO5 locus of Saccharomyces cerevisiae in transcriptionally repressed and activated states, were remodeled with RSC and ATP. Nucleosomes were translocated, and those originating on the promoter of repressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2096ef107b2dab44bb2b0374530a64
https://doi.org/10.1038/nsmb.2072
https://doi.org/10.1038/nsmb.2072
Publikováno v:
Proceedings of the National Academy of Sciences. 103:3090-3093
The RSC chromatin-remodeling complex completely disassembles a nucleosome in the presence of the histone chaperone Nap1 and ATP. Disassembly occurs in a stepwise manner, with the removal of H2A/H2B dimers, followed by the rest of the histones and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ebdabd78003b5dd9febd0c0d81e66e
https://doi.org/10.1073/pnas.0511050103
https://doi.org/10.1073/pnas.0511050103
AT-rich DNA is concentrated in the nucleosome-free regions (NFRs) associated with transcription start sites of most genes. We tested the hypothesis that AT-rich DNA engenders NFR formation by virtue of its rigidity and consequent exclusion of nucleos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217be7cf1cd122e1825767a455571135
https://europepmc.org/articles/PMC4233242/
https://europepmc.org/articles/PMC4233242/
Publikováno v:
Molecular Cell. 6(1):197-201
Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransfera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5590954bc2999a8399513b4befd731b1