Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Yagnesh Tailor"'
Autor:
Moritz Middelhoff, Henrik Nienhüser, Giovanni Valenti, H. Carlo Maurer, Yoku Hayakawa, Ryota Takahashi, Woosook Kim, Zhengyu Jiang, Ermanno Malagola, Krystle Cuti, Yagnesh Tailor, Leah B. Zamechek, Bernhard W. Renz, Michael Quante, Kelley S. Yan, Timothy C. Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Acetylcholine regulates intestinal epithelial secretion via muscarinic Gq-coupled receptors but its role in cell differentiation is unclear. Here, the authors show that Prox1-positive endocrine cells are sensors for the cholinergic intestinal niche a
Externí odkaz:
https://doaj.org/article/7eeb82d636ca4537aa0b570f2e30840f
Autor:
Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, N Patrik Brodin, Jiufeng Li, Samuel Asfaha, Laibin Liu, Yagnesh Tailor, Jinghang Zhang, Andrew K. Godwin, Wolfgang A. Tome, Timothy C. Wang, Chandan Guha, Jeffrey W. Pollard
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation inj
Externí odkaz:
https://doaj.org/article/248356ef46954e2da55e3e945b815504
Autor:
Zina Dubeykovskaya, Yiling Si, Xiaowei Chen, Daniel L. Worthley, Bernhard W. Renz, Aleksandra M. Urbanska, Yoku Hayakawa, Ting Xu, C. Benedikt Westphalen, Alexander Dubeykovskiy, Duan Chen, Richard A. Friedman, Samuel Asfaha, Karan Nagar, Yagnesh Tailor, Sureshkumar Muthupalani, James G. Fox, Jan Kitajewski, Timothy C. Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells relea
Externí odkaz:
https://doaj.org/article/67d8a761a2b64f5c8b8c4095b1685dfc
Autor:
H. Carlo Maurer, Krystle Cuti, Yagnesh Tailor, Giovanni Valenti, Bernhard W. Renz, Kelley S. Yan, Moritz Middelhoff, Timothy C. Wang, Yoku Hayakawa, Zhengyu Jiang, Woosook Kim, Leah Zamechek, Henrik Nienhüser, Ryota Takahashi, Michael Quante, Ermanno Malagola
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and immune functions through its actions on epithelial muscarinic Gq-coupled receptors such as M3R. Its role in the regulation of intestinal stem cell functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee91731db569e85664ebd23f1529223d
https://doaj.org/article/7eeb82d636ca4537aa0b570f2e30840f
https://doaj.org/article/7eeb82d636ca4537aa0b570f2e30840f
Autor:
Chandan Guha, Giovanni Valenti, Timothy C. Wang, Karan Nagar, Huan Deng, Zinaida A. Dubeykovskaya, Jan Kitajewski, Krystle Cuti, Yagnesh Tailor, Phaneendra K. Duddempudi
Publikováno v:
Cancer Gene Therapy
TFF2 is a small, secreted protein with anti-inflammatory properties. We previously have shown that TFF2 gene delivery via adenovirus (Ad-Tff2) suppresses colon tumor growth in colitis associated cancer. Therefore, systemic administration of TFF2 pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53e81e4efbe2f592080e501d1dc2934
https://doi.org/10.1038/s41417-018-0036-z
https://doi.org/10.1038/s41417-018-0036-z
Autor:
Timothy C. Wang, James G. Fox, Sozaburo Ihara, Mitsuru Konishi, Yagnesh Tailor, Takayuki Tanaka, Yoshihiro Hirata, Kazuhiko Koike, Xiaowei Chen, Hiroshi Onodera, Woosook Kim, Daniel L. Worthley, Hiroto Kinoshita, Antonia R. Sepulveda, Kosuke Sakitani, Haibo Liu, Stephen F. Konieczny, Samuel Asfaha, Zhengchuan Niu, Hiroshi Ariyama, Satoshi Ono, Nobumi Suzuki, Yoku Hayakawa, Huan Deng
Publikováno v:
Oncotarget
Paediatrics Publications
Paediatrics Publications
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the oxyntic gland within the gastric corpus. Chief cells at the base of the gastric corpus also express Mist1. The relevance of Mist1 expression as a marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0782088fd289e624ee87a1023b4f2d
http://europepmc.org/articles/PMC5762301
http://europepmc.org/articles/PMC5762301
Autor:
Ryan M. Davis, Massimiliano Spaliviero, Christopher H. Contag, Volker Neuschmelting, Yoomi Lee, Sanjiv S. Gambhir, Yagnesh Tailor, Matt van de Rijn, Moritz F. Kircher, Stephan Rogalla, Jeon Woong Kang, Yoku Hayakawa, Hazem Karabeber, Stefan Harmsen, Julie R. White, Ruimin Huang, Ricardo Toledo-Crow, Timothy C. Wang, Jason M. Samii
Cancers of the gastrointestinal (GI) tract are among the most frequent and most lethal cancers worldwide. An important reason for this high mortality is that early disease is typically asymptomatic, and patients often present with advanced, incurable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc5fcd775d173124bc11481718ccadf
https://europepmc.org/articles/PMC6428194/
https://europepmc.org/articles/PMC6428194/
Autor:
Yoku Hayakawa, Alina Iuga, Ruth A. White, Giovanni Valenti, C. Benedikt Westphalen, Yagnesh Tailor, Ryota Takahashi, Masaki Sunagawa, Jeanine M. Genkinger, Kenneth P. Olive, Zhengyu Jiang, Bernhard W. Renz, Marina Macchini, Takayuki Tanaka, Timothy C. Wang, Tamas A. Gonda
Publikováno v:
Gut. :gutjnl-2019
ObjectiveLong-standing chronic pancreatitis is an established risk factor for pancreatic ductal adenocarcinoma (PDAC). Interleukin-1β (IL-1β) has been associated in PDAC with shorter survival. We employed murine models to investigate the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f1abfd69c9e3f7eeb68e170af959f5
https://doi.org/10.1136/gutjnl-2019-319912
https://doi.org/10.1136/gutjnl-2019-319912
Autor:
Yagnesh Tailor, Kelley S. Yan, Moritz Middelhoff, Sozaburo Ihara, Yoku Hayakawa, Yoshihiro Hirata, Yohko Hikiba, Woosook Kim, Yukiko Oya, Chandan Guha, Naoko Higashijima, Tetsuo Ushiku, Samuel Asfaha, Kazuhiko Koike, Masashi Fukayama, Hiroto Kinoshita, Mayo Tsuboi, Mitsuru Konishi, Masahiro Hata, Timothy C. Wang, Ryota Niikura
Publikováno v:
Paediatrics Publications
Background & Aims The intestinal epithelium is maintained by long-lived intestinal stem cells (ISCs) that reside near the crypt base. Above the ISC zone, there are short-lived progenitors that normally give rise to lineage-specific differentiated cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bbe0fdad1108d1b20121cd6fe727b4
https://europepmc.org/articles/PMC6409180/
https://europepmc.org/articles/PMC6409180/
Autor:
Yagnesh Tailor, Marina Macchini, Timothy C. Wang, Bernhard W. Renz, Zahra Dantes, Moritz Middelhoff, J. Werner, Paul E. Oberstein, Alina Iuga, Richard A. Friedman, Huan Deng, C. Benedikt Westphalen, Kenneth P. Olive, Matthias Ilmer, Yoku Hayakawa, Giovanni Valenti, Ryota Takahashi, Ruth A. White, Helen Remotti, Zhengyu Jiang, Maximilian Reichert, Masaki Sunagawa, Martin K. Angele, Karan Nagar, Takayuki Tanaka
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8549ca9928310b47e87c729787fdd70
https://europepmc.org/articles/PMC6214763/
https://europepmc.org/articles/PMC6214763/