Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yagmur Azbazdar"'
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32243- (2024)
The Wnt signaling pathway is one of the most ancient and pivotal signaling cascades, governing diverse processes in development and cancer regulation. Within the realm of cancer treatment, genistein emerges as a promising candidate due to its multifa
Externí odkaz:
https://doaj.org/article/99839d4767e845a99666c3dd7be45bae
Autor:
Nydia Tejeda-Muñoz, Yagmur Azbazdar, Eric A. Sosa, Julia Monka, Pu-Sheng Wei, Grace Binder, Kuo-Ching Mei, Yerbol Z. Kurmangaliyev, Edward M. De Robertis
Publikováno v:
Biology Open, Vol 13, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/8209293db1834421b783329a357b4e1a
Autor:
Yagmur Azbazdar, Yeliz Demirci, Guillaume Heger, Dogac Ipekgil, Mustafa Karabicici, Gunes Ozhan
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2314-2336 (2023)
Hepatocellular carcinoma (HCC) is largely associated with aberrant activation of Wnt/β‐catenin signaling. Nevertheless, how membrane lipid composition is altered in HCC cells with abnormal Wnt signaling remains elusive. Here, by exploiting compreh
Externí odkaz:
https://doaj.org/article/dc7455d2e5cf49aca3967751b573d907
Autor:
Nydia Tejeda-Munoz, Yagmur Azbazdar, Julia Monka, Grace Binder, Alex Dayrit, Raul Ayala, Neil O'Brien, Edward M De Robertis
Publikováno v:
eLife, Vol 12 (2023)
Activation of the Wnt pathway lies at the core of many human cancers. Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryoni
Externí odkaz:
https://doaj.org/article/c050ab64f51242de82c4d3fd42c3621a
Autor:
Yagmur Azbazdar, Nydia Tejeda-Munoz, Julia C. Monka, Alex Dayrit, Grace Binder, Gunes Ozhan, Edward M. De Robertis
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108075- (2023)
Summary: Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis. This is accompanied by p
Externí odkaz:
https://doaj.org/article/e2b67310fbdd4d52b43b54a2b772dc95
Autor:
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hepatocellular carcinoma (HCC) is an aggressive, chemo resistant neoplasm with poor prognosis and limited treatment options. Exploring activated pathways upon drug treatment can be used to discover more effective anticancer agents to overcome therapy
Externí odkaz:
https://doaj.org/article/23b408dedbba4f1db6591f1dc369e47a
Autor:
Divya Dhasmana, Sapthaswaran Veerapathiran, Yagmur Azbazdar, Ashwin Venkata Subba Nelanuthala, Cathleen Teh, Gunes Ozhan, Thorsten Wohland
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Wnt proteins are a family of hydrophobic cysteine-rich secreted glycoproteins that regulate a gamut of physiological processes involved in embryonic development and tissue homeostasis. Wnt ligands are post-translationally lipidated in the endoplasmic
Externí odkaz:
https://doaj.org/article/48fc5ba7012c426995415ee8ac1886fb
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis. As pathway misregulation has been extensively linked to pathological pr
Externí odkaz:
https://doaj.org/article/439b81bb8ff14491bf325eb0905f2e99
Publikováno v:
Membranes, Vol 11, Iss 11, p 844 (2021)
Wnt signaling pathways constitute a group of signal transduction pathways that direct many physiological processes, such as development, growth, and differentiation. Dysregulation of these pathways is thus associated with many pathological processes,
Externí odkaz:
https://doaj.org/article/7b296f0c4190481684d96ab91df5ee9f
Autor:
Yagmur Azbazdar, Ozgun Ozalp, Erdinc Sezgin, Sapthaswaran Veerapathiran, Anna L. Duncan, Mark S. P. Sansom, Christian Eggeling, Thorsten Wohland, Ezgi Karaca, Gunes Ozhan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
While the lateral organization of plasma membrane components has been shown to control binding of Wnt ligands to their receptors preferentially in the ordered membrane domains, the role of posttranslational lipid modification of Wnt on this selective
Externí odkaz:
https://doaj.org/article/a9724d169876401287684486b7187c3e