Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yagiz Alp Aksoy"'
Publikováno v:
Cells, Vol 13, Iss 5, p 372 (2024)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the degeneration of motor neurons. Mutations in the cyclin F (CCNF) and fused in sarcoma (FUS) genes have been associated with ALS pathology. In this stud
Externí odkaz:
https://doaj.org/article/27290d26c9b542679004d4b5fd60b2d1
Autor:
G Gregory Neely, Alex C Keene, Peter Duchek, Elaine C Chang, Qiao-Ping Wang, Yagiz Alp Aksoy, Mark Rosenzweig, Michael Costigan, Clifford J Woolf, Paul A Garrity, Josef M Penninger
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24343 (2011)
Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage t
Externí odkaz:
https://doaj.org/article/bdd3f39444e548fe96b383fbd9e6c2b2
Autor:
Wei Deng, Yagiz Alp Aksoy, Rhiannon P. Kuchel, Tzong-Tyng Hung, Ewa M. Goldys, Wenjie Chen, Biyao Yang, Shane T. Grey, Nathan W. Zammit
Publikováno v:
ACS Applied Materials & Interfaces. 12:52433-52444
The CRISPR-Cas9 and related systems offer a unique genome-editing tool allowing facile and efficient introduction of heritable and locus-specific sequence modifications in the genome. Despite its molecular precision, temporal and spatial control of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faf85b78c59620414bf488ee8af398b
https://doi.org/10.1021/acsami.0c16380
https://doi.org/10.1021/acsami.0c16380
Autor:
Christopher E Denes, Daniel Hesselson, Alexander J. Cole, Yagiz Alp Aksoy, Geng Li, G. Gregory Neely
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8571, p 8571 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Modification of the human genome has immense potential for preventing or treating disease. Modern genome editing techniques based on CRISPR/Cas9 show great promise for altering disease-relevant genes. The efficacy of precision editing at CRISPR/Cas9-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9315adfba465f9d31357fc10839dee04
https://www.mdpi.com/1422-0067/22/16/8571
https://www.mdpi.com/1422-0067/22/16/8571
Autor:
Sharron Chow, Daniel Hesselson, Roger S. Chung, David T. Nguyen, Gilles J. Guillemin, Yagiz Alp Aksoy, Nicholas J. Cole
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-9 (2019)
Communications Biology
Communications Biology
Precise genome editing is limited by the inefficiency of homology-directed repair (HDR) compared to the non-homologous end-joining (NHEJ) of double strand breaks (DSBs). The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805b0c1d5edf59fa5400101ae5b7f335
http://link.springer.com/article/10.1038/s42003-019-0444-0
http://link.springer.com/article/10.1038/s42003-019-0444-0
The CRISPR-Cas9 and related systems offer a unique genome editing tool allowing facile and efficient introduction of heritable and locus-specific sequence modifications in the genome. Despite its molecular precision, temporal and spatial control of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a2f667fca181d3cb30322e475cc0f3
Autor:
Wei Deng, G. Gregory Neely, Gilles J. Guillemin, Nicholas J. Cole, Jack J Stoddart, Daniel Hesselson, Yagiz Alp Aksoy, Roger S. Chung
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 126:105821
Mutations in fused-in-sarcoma (FUS) and TAR DNA binding protein-43 (TDP-43; TARDBP) are known to cause the severe adult-onset neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Proteinopathy caused by cellular stresses such as endoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88b8da56507ce4dc00352afcd6d6a78
https://doi.org/10.1016/j.biocel.2020.105821
https://doi.org/10.1016/j.biocel.2020.105821
Autor:
Michael Costigan, Yagiz Alp Aksoy, Alex C. Keene, Qiao-Ping Wang, Elaine Chang, Margaret Rosenzweig, G. Gregory Neely, Peter Duchek, Clifford J. Woolf, Paul A. Garrity, Josef M. Penninger
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 8, p e24343 (2011)
PLoS ONE, Vol 6, Iss 8, p e24343 (2011)
Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc405976e0501fa2a148c705e7586e3
Publikováno v:
Australian Journal of Zoology. 60:334
The Lake Eacham rainbowfish (Melanotaenia eachamensis) was once thought to be confined to its type locality within the Lake Eacham World Heritage National Park. M. eachamensis disappeared from the lake following the translocation of several species i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74dec5b2d1c3d16043719ce4c26f9815
https://doi.org/10.1071/zo12106
https://doi.org/10.1071/zo12106