Enhancing preventive and therapeutic cancer vaccine efficacy through biotherapeutic ligand-associated extracellular vesicles.

Autor: Kahraman T; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Thorvacs Vaccine, Drug, Biologic Products and Biotechnology Research and Development Company, 06800 Ankara, Turkey., Akpinar GG; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, SE-171 64 Stockholm, Sweden., Yildirim M; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Thorlab, Therapeutic Oligonucleotide Research Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey., Larssen P; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, SE-171 64 Stockholm, Sweden., Bayyurt-Kocabas B; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Dept of Biological Sciences, METU, 06800 Ankara, Turkey., Yagci FC; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Thorvacs Vaccine, Drug, Biologic Products and Biotechnology Research and Development Company, 06800 Ankara, Turkey., Gursel A; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey., Horuluoglu BH; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey., Yazar V; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey., Ayanoglu IC; Dept of Biological Sciences, METU, 06800 Ankara, Turkey., Yildirim TC; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Thorlab, Therapeutic Oligonucleotide Research Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey., Evcili I; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Thorlab, Therapeutic Oligonucleotide Research Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey., Yilmaz IC; Thorlab, Therapeutic Oligonucleotide Research Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey; Dept of Biological Sciences, METU, 06800 Ankara, Turkey., Eldh M; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, SE-171 64 Stockholm, Sweden., Gabrielsson S; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, SE-171 64 Stockholm, Sweden., Guler U; Department of Chemistry, Hacettepe University, 06800 Ankara, Turkey., Salih B; Department of Chemistry, Hacettepe University, 06800 Ankara, Turkey., Gursel M; Thorlab, Therapeutic Oligonucleotide Research Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey; Dept of Biological Sciences, METU, 06800 Ankara, Turkey., Gursel I; Department of Molecular Biology and Genetics, Bilkent University, 06800, Bilkent, Ankara, Turkey; Thorlab, Therapeutic Oligonucleotide Research Laboratory, Izmir Biomedicine and Genome Center, Izmir, Turkey. Electronic address: ihsangursel@ibg.edu.tr.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Oct 25; Vol. 376, pp. 618-631. Date of Electronic Publication: 2024 Oct 25.

Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity.

Autor: Kahraman T; Science Faculty, Department of Molecular Biology and Genetics, Bilkent University , Ankara , Turkey., Gucluler G; Science Faculty, Department of Molecular Biology and Genetics, Bilkent University , Ankara , Turkey., Simsek I; Division of Rheumatology, Gulhane School of Medicine , Ankara , Turkey., Yagci FC; Science Faculty, Department of Molecular Biology and Genetics, Bilkent University , Ankara , Turkey., Yildirim M; Science Faculty, Department of Molecular Biology and Genetics, Bilkent University , Ankara , Turkey., Ozen C; Department of Biotechnology, Middle East Technical University , Ankara , Turkey., Dinc A; Division of Rheumatology, Gulhane School of Medicine , Ankara , Turkey., Gursel M; Department of Biological Sciences, Middle East Technical University , Ankara , Turkey., Ikromzoda L; Nanotechnology Research and Application Center, Sabanci University , Istanbul , Turkey., Sutlu T; Nanotechnology Research and Application Center, Sabanci University , Istanbul , Turkey., Gay S; Department of Rheumatology, University Hospital Zurich , Zurich , Switzerland., Gursel I; Science Faculty, Department of Molecular Biology and Genetics, Bilkent University , Ankara , Turkey.

Publikováno v: Journal of extracellular vesicles [J Extracell Vesicles] 2017 Feb 28; Vol. 6 (1), pp. 1284449. Date of Electronic Publication: 2017 Feb 28 (Print Publication: 2017).

CpG ODN nanorings induce IFNα from plasmacytoid dendritic cells and demonstrate potent vaccine adjuvant activity.

Autor: Gungor B; Department of Biological Sciences, Middle East Technical University, 06800 Ankara, Turkey., Yagci FC, Tincer G, Bayyurt B, Alpdundar E, Yildiz S, Ozcan M, Gursel I, Gursel M

Publikováno v: Science translational medicine [Sci Transl Med] 2014 May 07; Vol. 6 (235), pp. 235ra61.

Mammalian telomeric DNA suppresses endotoxin-induced uveitis.

Autor: Yagci FC; Biotherapeutic Oligonucleotide Laboratory, Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey., Aslan O, Gursel M, Tincer G, Ozdamar Y, Karatepe K, Akcali KC, Gursel I

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2010 Sep 10; Vol. 285 (37), pp. 28806-11. Date of Electronic Publication: 2010 Jul 14.