CAMSAP2 localizes to the Golgi in islet β-cells and facilitates Golgi-ER trafficking

Autor: Kung-Hsien Ho, Anissa Jayathilake, Yagan Mahircan, Aisha Nour, Anna B. Osipovich, Mark A. Magnuson, Guoqiang Gu, Irina Kaverina

Publikováno v: iScience, Vol 26, Iss 2, Pp 105938- (2023)

Summary: Glucose stimulation induces the remodeling of microtubules, which potentiates insulin secretion in pancreatic β-cells. CAMSAP2 binds to microtubule minus ends to stabilize microtubules in several cultured clonal cells. Here, we report that

Externí odkaz: https://doaj.org/article/fcefcd0718854146891e21c7a8ebb26a

Metabolic Stress Levels Influence the Ability of Myelin Transcription Factors to Regulate β-Cell Identity and Survival.

Autor: Tong, Xin, Yagan, Mahircan, Hu, Ruiying, Nevills, Simone, Doss, Teri D., Stein, Roland W., Balamurugan, Appakalai N., Gu, Guoqiang

Publikováno v: Diabetes; Oct2024, Vol. 73 Issue 10, p1662-1672, 11p

Pancreatic islet α cells regulate microtubule stability in neighboring β cells to tune insulin secretion and induce functional heterogeneity in individual mouse and human islets.

Autor: Ho KH, Barmaver SN, Hu R, Yagan M, Ahmed HK, Kaverina I, Gu G

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.

Endocrine islet β-cell subtypes with differential function are derived from biochemically distinct embryonic endocrine islet progenitors that are regulated by maternal nutrients.

Autor: Gu G; Vanderbilt University., Brown M; Vanderbilt University., Agan V; Vanderbilt University., Nevills S; Vanderbilt University., Hu R; Vanderbilt University Medical Center., Simmons A; Vanderbilt University., Xu Y; Vanderbilt University., Yang Y; Vanderbilty University School of Medicine., Yagan M; Vanderbilt University., Najam S; Vanderbilt University., Dadi P; Vanderbilt University., Sampson L; Vanderbilt University., Magnuson M; Vanderbilt University., Jacobson D; Vanderbilt University., Lau K; Vanderbilt University., Hodges E; Vanderbilt University.

Publikováno v: Research square [Res Sq] 2024 Mar 07. Date of Electronic Publication: 2024 Mar 07.