Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Yael Strulovici‐Barel"'
High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-4 (2023)
Abstract While asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling and angiogenesis in some individu
Externí odkaz:
https://doaj.org/article/2599d5fcbaf34d05ac3b5d221e0e91e2
Autor:
Mahboubeh R. Rostami, Michelle G. LeBlanc, Yael Strulovici-Barel, Wulin Zuo, Jason G. Mezey, Sarah L. O’Beirne, Robert J. Kaner, Philip L. Leopold, Ronald G. Crystal
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-17 (2021)
Abstract The club cell, a small airway epithelial (SAE) cell, plays a central role in human lung host defense. We hypothesized that subpopulations of club cells with distinct functions may exist. The SAE of healthy nonsmokers and healthy cigarette sm
Externí odkaz:
https://doaj.org/article/08d73db7b3394c4286f74267ce717330
Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids
Autor:
Sarah L. O’Beirne, Jacqueline Salit, Robert J. Kaner, Ronald G. Crystal, Yael Strulovici-Barel
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background The first step in SARS-CoV-2 infection is binding of the virus to angiotensin converting enzyme 2 (ACE2) on the airway epithelium. Asthma affects over 300 million people world-wide, many of whom may encounter SARS-CoV-2. Epidemiol
Externí odkaz:
https://doaj.org/article/cd423978c73e4b28b23aeac1a498ee54
Autor:
Wu-lin Zuo, Mahboubeh R. Rostami, Shushila A. Shenoy, Michelle G. LeBlanc, Jacqueline Salit, Yael Strulovici-Barel, Sarah L. O’Beirne, Robert J. Kaner, Philip L. Leopold, Jason G. Mezey, Juergen Schymeinsky, Karsten Quast, Sudha Visvanathan, Jay S. Fine, Matthew J. Thomas, Ronald G. Crystal
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specific cell populations co
Externí odkaz:
https://doaj.org/article/af8f66ce0af64a4dbed6220fd72ca500
Autor:
Matthew S Walters, Jacqueline Salit, Jin Hyun Ju, Michelle R Staudt, Robert J Kaner, Allison M Rogalski, Teniola B Sodeinde, Riyaad Rahim, Yael Strulovici-Barel, Jason G Mezey, Ahmad M Almulla, Hisham Sattar, Mai Mahmoud, Ronald G Crystal
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0171112 (2017)
Waterpipe (also called hookah, shisha, or narghile) smoking is a common form of tobacco use in the Middle East. Its use is becoming more prevalent in Western societies, especially among young adults as an alternative form of tobacco use to traditiona
Externí odkaz:
https://doaj.org/article/3dc444c2378b428daea0e1b6f7b87b3b
Autor:
Guoqing Wang, Rui Wang, Yael Strulovici-Barel, Jacqueline Salit, Michelle R Staudt, Joumana Ahmed, Ann E Tilley, Jenny Yee-Levin, Charleen Hollmann, Ben-Gary Harvey, Robert J Kaner, Jason G Mezey, Sriram Sridhar, Sreekumar G Pillai, Holly Hilton, Gerhard Wolff, Hans Bitter, Sudha Visvanathan, Jay S Fine, Christopher S Stevenson, Ronald G Crystal
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120824 (2015)
Even after quitting smoking, the risk of the development of chronic obstructive pulmonary disease (COPD) and lung cancer remains significantly higher compared to healthy nonsmokers. Based on the knowledge that COPD and most lung cancers start in the
Externí odkaz:
https://doaj.org/article/1b6f44e9a64d47daab4df117cf0df208
Autor:
Dorothy M Ryan, Thomas L Vincent, Jacqueline Salit, Matthew S Walters, Francisco Agosto-Perez, Renat Shaykhiev, Yael Strulovici-Barel, Robert J Downey, Lauren J Buro-Auriemma, Michelle R Staudt, Neil R Hackett, Jason G Mezey, Ronald G Crystal
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88051 (2014)
Genome-wide association studies (GWAS) and candidate gene studies have identified a number of risk loci associated with the smoking-related disease COPD, a disorder that originates in the airway epithelium. Since airway basal cell (BC) stem/progenito
Externí odkaz:
https://doaj.org/article/a96e183ed68f47ce9a2a1c5832f7f587
Autor:
Ben-Gary Harvey, Yael Strulovici-Barel, Thomas L Vincent, Jason G Mezey, Ramya Raviram, Cynthia Gordon, Jacqueline Salit, Ann E Tilley, Augustine Chung, Abraham Sanders, Ronald G Crystal
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72669 (2013)
The distribution of lung disease induced by inhaled cigarette smoke is complex, depending on many factors. With the knowledge that the small airway epithelium (SAE) is the earliest site of smoking-induced lung disease, and that the SAE gene expressio
Externí odkaz:
https://doaj.org/article/aa04e3b9047f4ec39a2834a45205af10
Autor:
Rui Wang, Joumana Ahmed, Guoqing Wang, Ibrahim Hassan, Yael Strulovici-Barel, Neil R Hackett, Ronald G Crystal
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e14793 (2011)
The Wnt pathway mediates differentiation of epithelial tissues; depending on the tissue types, Wnt can either drive or inhibit the differentiation process. We hypothesized that key genes in the Wnt pathway are suppressed in the human airway epitheliu
Externí odkaz:
https://doaj.org/article/a3329c527c454c5eab5f56b176b58ad6
Autor:
Ann E Tilley, Timothy P O'Connor, Neil R Hackett, Yael Strulovici-Barel, Jacqueline Salit, Nancy Amoroso, Xi Kathy Zhou, Tina Raman, Larsson Omberg, Andrew Clark, Jason Mezey, Ronald G Crystal
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22798 (2011)
The first changes associated with smoking are in the small airway epithelium (SAE). Given that smoking alters SAE gene expression, but only a fraction of smokers develop chronic obstructive pulmonary disease (COPD), we hypothesized that assessment of
Externí odkaz:
https://doaj.org/article/e32ec4eff4084ed1bc09f56571e514e3