20S proteasomes secreted by the malaria parasite promote its growth

Autor: Elya Dekel, Dana Yaffe, Irit Rosenhek-Goldian, Gili Ben-Nissan, Yifat Ofir-Birin, Mattia I. Morandi, Tamar Ziv, Xavier Sisquella, Matthew A. Pimentel, Thomas Nebl, Eugene Kapp, Yael Ohana Daniel, Paula Abou Karam, Daniel Alfandari, Ron Rotkopf, Shimrit Malihi, Tal Block Temin, Debakshi Mullick, Or-Yam Revach, Ariel Rudik, Nir S. Gov, Ido Azuri, Ziv Porat, Giulia Bergamaschi, Raya Sorkin, Gijs J. L. Wuite, Ori Avinoam, Teresa G. Carvalho, Sidney R. Cohen, Michal Sharon, Neta Regev-Rudzki

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Plasmodium falciparum secretes extracellular vesicles (EVs) while growing inside red blood cells (RBCs). Here the authors show that these EVs contain assembled and functional 20S proteasome complexes that remodel the cytoskeleton of naïve human RBCs

Externí odkaz: https://doaj.org/article/2714bdc7c6d440079ba403f2120173c1

20S proteasomes secreted by the malaria parasite promote its growth

Autor: Nir S. Gov, Gili Ben-Nissan, Ziv Porat, Dana Yaffe, Tal Block Temin, Michal Sharon, Ron Rotkopf, Raya Sorkin, Irit Rosenhek-Goldian, Daniel Alfandari, Teresa Carvalho, Ori Avinoam, Eugene A. Kapp, Debakshi Mullick, Gijs J.L. Wuite, Neta Regev-Rudzki, Yifat Ofir-Birin, Tamar Ziv, Matthew A. Pimentel, Giulia Bergamaschi, Ariel Rudik, Thomas Nebl, Mattia I. Morandi, Shimrit Malihi, Or-Yam Revach, Xavier Sisquella, Sidney R. Cohen, Elya Dekel, Ido Azuri, Paula Abou Karam, Yael Ohana Daniel

Publikováno v: Nature Communications, 12(1):1172, 1-19. Nature Publishing Group
Nature Communications
Dekel, E, Yaffe, D, Rosenhek-Goldian, I, Ben-Nissan, G, Ofir-Birin, Y, Morandi, M I, Ziv, T, Sisquella, X, Pimentel, M A, Nebl, T, Kapp, E, Ohana Daniel, Y, Karam, P A, Alfandari, D, Rotkopf, R, Malihi, S, Temin, T B, Mullick, D, Revach, O Y, Rudik, A, Gov, N S, Azuri, I, Porat, Z, Bergamaschi, G, Sorkin, R, Wuite, G J L, Avinoam, O, Carvalho, T G, Cohen, S R, Sharon, M & Regev-Rudzki, N 2021, ' 20S proteasomes secreted by the malaria parasite promote its growth ', Nature Communications, vol. 12, no. 1, 1172, pp. 1-19 . https://doi.org/10.1038/s41467-021-21344-8
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms, making them both a fascinating host cell, in general, and an intriguing choice for the deadly malaria parasite Plasmodium falciparum (Pf), in particular. Pf, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e1a42c6a1d186f80e14ae5e2384ee8
https://doi.org/10.1038/s41467-021-21344-8