Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yael Nadel"'
Autor:
Ophir Ethan, Joanna Lecka, Diana Meltzer, Ortal Danino, Fernand-Pierre Gendron, Bilha Fischer, Jean Sévigny, Yael Nadel, Guillaume Arguin
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5764-5773
P2Y6 receptor (P2Y6-R) is involved in various physiological and pathophysiological events. With a view to set rules for the design of UDP-based reversible P2Y6-R antagonists as potential drugs, we established structure-activity relationship of UDP an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0c370d30203116777cc8b1a3b16ae0
https://doi.org/10.1016/j.bmc.2015.07.004
https://doi.org/10.1016/j.bmc.2015.07.004
Autor:
Djordje Grbic, Bilha Fischer, Guillaume Arguin, Tamar Ginsburg-Shmuel, Michael Haas, Fernand-Pierre Gendron, Yael Nadel, Georg Reiser
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5483-5495
P2Y(6) nucleotide receptor (P2Y(6)-R) plays important physiological roles, such as insulin secretion and reduction of intraocular pressure. However, this receptor is still lacking potent and selective agonists to be used as potential drugs. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41810ec2c6130184b3bd284f81fd33c
https://doi.org/10.1016/j.bmc.2012.07.042
https://doi.org/10.1016/j.bmc.2012.07.042
Autor:
Gary A. Weisman, Bilha Fischer, Jean Sévigny, Gal Ben-David, Yael Nadel, Georg Reiser, Jean M. Camden, Yocheved Gilad, Hanoch Senderowitz, Daniel Förster, Sarah Kenigsberg, Joanna Lecka
Publikováno v:
Journal of medicinal chemistry. 57(11)
Aberrant nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) activity is associated with chondrocalcinosis, osteoarthritis, and type 2 diabetes. The potential of NPP1 inhibitors as therapeutic agents, and the scarceness of their structure-activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456bc78feda89c1466f3abb72a115d10
https://pubmed.ncbi.nlm.nih.gov/24846781
https://pubmed.ncbi.nlm.nih.gov/24846781
Publikováno v:
Inorganic chemistry. 52(19)
On the basis of the high affinity of Zn(2+) to sulfur and imidazole, we targeted nucleotides such as GDP-β-S, ADP-β-S, and AP3(β-S)A, as potential biocompatible Zn(2+)-chelators. The thiophosphate moiety enhanced the stability of the Zn(2+)-nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703d4c7cb865ca5918ddd150661ecccb
https://pubmed.ncbi.nlm.nih.gov/24050595
https://pubmed.ncbi.nlm.nih.gov/24050595
Publikováno v:
The Journal of organic chemistry. 78(17)
Nucleoside-(5'→P) methylenebisphosphonodithioate analogues are bioisosteres of natural nucleotides. The potential therapeutic applications of these analogues are limited by their relative instability. With a view toward improving their chemical and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bbcd10d8de884bb3ab588adc9aaf12
https://pubmed.ncbi.nlm.nih.gov/23895237
https://pubmed.ncbi.nlm.nih.gov/23895237
Publikováno v:
Journal of medicinal chemistry. 56(12)
Currently, there is a need for novel, biocompatible, and effective neuroprotectants for the treatment of neurodegenerative diseases and brain injury associated with oxidative damage. Here, we developed nucleotide-based neuroprotectants acting dually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed59186f720fb4a7f7b51a863885312
https://pubmed.ncbi.nlm.nih.gov/23751098
https://pubmed.ncbi.nlm.nih.gov/23751098
Publikováno v:
The Journal of nutrition. 133(5)
The effect of early posthatch feeding on skeletal muscle growth and satellite cell myogenesis was studied in turkey poults. Poults were either fed immediately posthatch or food-deprived for the first 48 h and then refed for the rest of the experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d485beeb1826ee2e28c01dc8e74cebc7
https://pubmed.ncbi.nlm.nih.gov/12730425
https://pubmed.ncbi.nlm.nih.gov/12730425
Publikováno v:
Dalton Transactions. 41:8539
Amyloid beta (Aβ) peptide is known to precipitate and form aggregates with zinc and copper ions in vitro and, in vivo in Alzheimer's disease (AD) patients. Metal-ion-chelation was suggested as therapy for the metal-ion-induced Aβ aggregation, metal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44be134284a5bcd461e687d22214979e
https://doi.org/10.1039/c2dt30631j
https://doi.org/10.1039/c2dt30631j