Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yael Marantz"'
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S8-S9
Autor:
Rina Kashi, Aric Orbach, Victor Piryatinsky, Daphna Laifenfeld, Mark A. Ator, Tal Birnberg, Doron Shinar, Tal Hingaly, Efrat Rubinstein, Emanuel Raymond, Einat Amit-Romach, Fadi Towfic, Ralph Laufer, Yael Marantz, Iris Grossman, Joel Kaye, Ignacio S. Caballero, Volker Knappertz, Michael R. Hayden
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Laquinimod is an oral drug currently being evaluated for the treatment of relapsing, remitting, and primary progressive multiple sclerosis and Huntington’s disease. Laquinimod exerts beneficial activities on both the peripheral immune system and th
Autor:
Hugo M. Vargas, Yang Xu, Jerry Siu, Janet Buys, Michelle Horner, Jian Lin, Ashis Saha, Han Xu, Michele McElvain, Anurag Sharadendu, Scot Middleton, Roland Burli, Yael Marantz, Dalia Segal, Kevin Salyers, Mercedes Lobera, Dilara Mccauley, Srinivas Chereku, Xiang Yu, Nili Schutz, Michael Schrag
Publikováno v:
ACS Medicinal Chemistry Letters. 2:97-101
We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P1 agonist with >1000× selectivity over S1
Publikováno v:
Journal of Chemical Information and Modeling. 49:623-633
Identifying active compounds (hits) that bind to biological targets of pharmaceutical relevance is the cornerstone of drug design efforts. Structure based virtual screening, namely, the in silico evaluation of binding energies and geometries between
Autor:
Paul E. Gold, Frank Lezoualc'h, Yael Marantz, Sharon Shacham, Silvia Noiman, Sylvain J. Robert, Joseph Rutkowski, Aline Dumuis, Joël Bockaert, Michael E. Ragozzino, Eric G. Mohler, Monique Gastineau
Publikováno v:
Neuropharmacology. 53:563-573
Recent evidence suggests that 5-hydroxytryptamine (5-HT)(4) receptor activity enhances cognition and provides neuroprotection. Here we report the effects of VRX-03011, a novel partial 5-HT(4) agonist, that is both potent (K(i) approximately 30 nM) an
Autor:
Yael Marantz, Alexander Heifetz, Dora Warshaviak, Silvia Noiman, Boaz Inbal, Maya Topf, Merav Fichman, Oren M. Becker, Zvi Naor, Noa Avisar, Sharon Shacham, Ori Kalid, Shay Bar-Haim
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 57:51-86
G-protein coupled receptors (GPCRs) are a major group of drug targets for which only one x-ray structure is known (the nondrugable rhodopsin), limiting the application of structure-based drug discovery to GPCRs. In this paper we present the details o
Publikováno v:
Biochemistry. 40:15086-15097
Proton-transfer reactions on the surface of bovine heart cytochrome c oxidase were investigated by combining a laser-induced proton-pulse technique with molecular modeling. The experimental approach simultaneously monitors the state of pyranine proto
Autor:
Menachem Gutman, Sharon Checover, Yael Marantz, Dieter Oesterhelt, Matthias Pfeiffer, Norbert A. Dencher, Joerg Tittor, Esther Nachliel
Publikováno v:
Biochemistry. 40:4281-4292
The cytoplasmic surface of bacteriorhodopsin is characterized by a group of carboxylates that function as a proton attractive domain [Checover, S., Nachliel, E., Dencher, N. A., and Gutman, M. (1997) Biochemistry 36, 13919-13928]. To identify these c
Autor:
Oren Becker, Sharon Shacham, Zvi Naor, Silvia Noiman, Maya Topf, Fabian Glaser, Yael Marantz, Shay Bar-Haim, Noa Avisar
Publikováno v:
Medicinal Research Reviews. 21:472-483
G-protein-coupled receptors (GPCRs) are a large and functionally diverse protein superfamily, which form a seven transmembrane (TM) helices bundle with alternating extra-cellular and intracellular loops. GPCRs are considered to be one of the most imp
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1458:120-134
The passage of proton trough proteins is common to all membranal energy conserving enzymes. While the routes differ among the various proteins, the mechanism of proton propagation is based on the same chemical–physical principles. The proton progre