Výsledky vyhledávání - "Yael Leitner-Dagan"

Supplementary Table 1, Figure 1 from Low Integrated DNA Repair Score and Lung Cancer Risk

Autor: Zvi Livneh, Tamar Paz-Elizur, Gad Rennert, Laurence S. Freedman, Edna Schechtman, Hedy S. Rennert, Dalia Elinger, Ran Kremer, Mila Pinchev, Yael Leitner-Dagan, Ziv Sevilya

PDF file - 856K, Supplementary Table 1, presenting Conditional logistic regression model relating the three biomarkers OGG1, MPG and APE1 to lung cancer. Supplementary Figure 1, presenting Association of DNA repair activity with lung cancer risk, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06974947377e2a5ef07189ce5f85683f
https://doi.org/10.1158/1940-6207.22524623

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DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression

Autor: Bruce A.J. Ponder, Tamar Paz-Elizur, Ronen Fluss, Martin O'Reilly, Robert C. Rintoul, Federico M. Giorgi, Laurence S. Freedman, Hyunjin Kim, Zvi Livneh, Yael Leitner-Dagan, Barak Markus, Yentl Evgy, Kerstin B. Meyer

Publikováno v: JNCI Cancer Spectrum

Background Improving lung cancer risk assessment is required because current early-detection screening criteria miss most cases. We therefore examined the utility for lung cancer risk assessment of a DNA Repair score obtained from OGG1, MPG, and APE1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41a4230dc4d045cd8c7f28752cc708b
http://europepmc.org/articles/PMC7012022

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Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk

Autor: Ran Kremer, Tamar Paz-Elizur, Gad Rennert, Ziv Sevilya, Zvi Livneh, Hedy S. Rennert, Mila Pinchev, Dalia Elinger, Yael Leitner-Dagan, Laurence S. Freedman, Flavio Lejbkowicz

Publikováno v: Carcinogenesis

Summary We developed radioactivity-based and fluorescence-based assays for the DNA repair enzyme APE1 and showed that its decreased activity is associated with increased lung cancer risk. This suggests that ‘bad DNA repair’ rather than ‘bad luc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e6ca67d400864dbb1e6a9058c61821
http://europepmc.org/articles/PMC4552243

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Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk

Autor: Edna Schechtman, Hedy S. Rennert, Mila Pinchev, Gad Rennert, Ziv Sevilya, Laurence S. Freedman, Yael Leitner-Dagan, Tamar Paz-Elizur, Dalia Elinger, Ran Kremer, Zvi Livneh

Publikováno v: Carcinogenesis. 35:2763-2770

DNA repair is a major mechanism for minimizing mutations and reducing cancer risk. Here, we present the development of reproducible and specific enzymatic assays for methylpurine DNA glycosylase (MPG) repairing the oxidative lesions 1,N6-ethenoadenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca902ace52a44b23a5e6fce0ad20bcd4
https://doi.org/10.1093/carcin/bgu214

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N-Methylpurine DNA Glycosylase and OGG1 DNA Repair Activities: Opposite Associations With Lung Cancer Risk

Autor: Gad Rennert, Edna Schechtman, Tamar Paz-Elizur, Ziv Sevilya, Mila Pinchev, Zvi Livneh, Hedy S. Rennert, Yael Leitner-Dagan, Dalia Elinger, Laurence S. Freedman, Ran Kramer, Laila C. Roisman

Publikováno v: JNCI Journal of the National Cancer Institute

Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb888358715509e63570135ad32042e
https://doi.org/10.1093/jnci/djs445

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Development of an enzymatic DNA repair assay for molecular epidemiology studies: Distribution of OGG activity in healthy individuals

Autor: Edna Schechtman, Sara Blumenstein, Yael Leitner-Dagan, Zvi Livneh, Dalia Elinger, Alain Berrebi, Tamar Paz-Elizur, Meir Krupsky

Publikováno v: DNA Repair. 6:45-60

While the role of reduced DNA repair in susceptibility to hereditary cancers is well established, its role in sporadic cancer is less understood. One of the reasons is the lack of specific DNA repair assays that are suitable for epidemiology studies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb84e0b5accfedd2688323cbcd694f60
https://doi.org/10.1016/j.dnarep.2006.08.003

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DNA sequence context greatly affects the accuracy of bypass across an ultraviolet light 6-4 photoproduct in mammalian cells

Autor: Pola Shriber, Nicholas E. Geacintov, Tamar Paz-Elizur, Zvi Livneh, Yael Leitner-Dagan

Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism carried out by low-fidelity DNA polymerases that bypass DNA lesions, which overcomes replication stalling. Despite the miscoding nature of most common DNA lesions, several of them ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2823171c8a3a86b7b0987eaab708fd1
https://europepmc.org/articles/PMC4871125/

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CHRD, a plant member of the evolutionarily conserved YjgF family, influences photosynthesis and chromoplastogenesis

Autor: Alexander Vainstein, Tzvi Tzfira, Yael Leitner-Dagan, Elena Shklarman, Marianna Ovadis, Amir Zuker, Itzhak Ohad

Publikováno v: Planta. 225:89-102

Studies on the carotenoid-overaccumulating structures in chromoplasts have led to the characterization of proteins termed plastid lipid-associated proteins (PAPs), involved in the sequestration of hydrophobic compounds. Here we characterize the PAP C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a7c2bc9a746bc723fab2082f6a87f3
https://doi.org/10.1007/s00425-006-0332-y

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