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Akademický článek

Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs.

Autor: Sagi Tamir, John A Zuris, Lily Agranat, Colin H Lipper, Andrea R Conlan, Dorit Michaeli, Yael Harir, Mark L Paddock, Ron Mittler, Zvi Ioav Cabantchik, Patricia A Jennings, Rachel Nechushtai

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e61202 (2013)

Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfr

Externí odkaz: https://doaj.org/article/784e2a071f1348ef8f98f442fc369770

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Spontaneous in vitro hatching of the human blastocyst: the proteomics of initially hatching cells

Autor: Miriam Almagor, Zeev Shoham, Yael Harir, Yishai Levin, Sheila Fieldust, Yuval Or, Rona Halevy Amiran

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 56:859-865

Spontaneous in vitro hatching of human blastocysts starts with the formation of a tunnel through the zona pellucida (ZP) by cellular projections of trophoblast cells. Our aim was to identify the proteins that are upregulated in these initially hatchi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17377325ad30dc551208d5576ad5d2f0
https://doi.org/10.1007/s11626-020-00522-w

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NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Autor: Vladimir Shulaev, Luhua Song, Ron Mittler, Sarah H. Holt, Abraham Hochberg, Yang Sung Sohn, Rachel Nechushtai, José N. Onuchic, Andrea R. Conlan, Dorit Michaeli, Yael Harir, Imad Matouk, Sagi Tamir, Ioav Z. Cabanchick, Patricia A. Jennings, Mark L. Paddock

Publikováno v: Proceedings of the National Academy of Sciences. 110:14676-14681

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc41401b447bc6bd14ad930b1e086e4
https://doi.org/10.1073/pnas.1313198110

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Ratio between inner cell mass diameter and blastocyst diameter is correlated with successful pregnancy outcomes of single blastocyst transfers

Autor: Zeev Shoham, Sheila Fieldust, Yael Harir, Miriam Almagor, Yuval Or

Publikováno v: Fertility and sterility. 106(6)

Objective To evaluate the ability to predict pregnancy outcomes of single-blastocyst transfers by measuring the ratio of inner cell mass (ICM) diameter to blastocyst diameter using time-lapse images. Design Retrospective cohort study. Setting Univers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0ffa7c2ba1238360f79f420093e56f
https://pubmed.ncbi.nlm.nih.gov/27567431

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Characterization of Arabidopsis NEET Reveals an Ancient Role for NEET Proteins in Iron Metabolism

Autor: Rachel Rosen, Rachel Nechushtai, Ohad Yogev, Yael Eisenberg-Domovich, Vincent Ma, Luhua Song, Oded Livnah, Yuting Luo, Ron Mittler, Yael Harir, John A. Zuris, Patricia A. Jennings, Zvi Ioav Cabantchik, Mark L. Paddock, Andrea R. Conlan, Dorit Michaeli

Publikováno v: The Plant Cell. 24:2139-2154

The NEET family is a newly discovered group of proteins involved in a diverse array of biological processes, including autophagy, apoptosis, aging, diabetes, and reactive oxygen homeostasis. They form a novel structure, the NEET fold, in which two pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46ca0bfe571ba1fee3442e575e65c86
https://doi.org/10.1105/tpc.112.097634

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Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein

Autor: Mark L. Paddock, José N. Onuchic, Sagi Tamir, Zvi Ioav Cabantchik, Andrea R. Conlan, Dorit Michaeli, Ron Mittler, John A. Zuris, Patricia A. Jennings, Maya Shvartsman, Rachel Nechushtai, Yael Harir

Publikováno v: Proceedings of the National Academy of Sciences. 108:13047-13052

MitoNEET (mNT) is an outer mitochondrial membrane target of the thiazolidinedione diabetes drugs with a unique fold and a labile [2Fe-2S] cluster. The rare 1-His and 3-Cys coordination of mNT’s [2Fe-2S] leads to cluster lability that is strongly de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560d39cd7434f1442186ce972d6a658f
https://doi.org/10.1073/pnas.1109986108

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Over-expression of CONSTANS-LIKE 5 can induce flowering in short-day grown Arabidopsis

Autor: Miriam Hassidim, Ido Kron, Yael Harir, Rachel M. Green, Esther Yakir

Publikováno v: Planta. 230:481-491

To ensure that the initiation of flowering occurs at the correct time of year, plants need to integrate a diverse range of external and internal signals. In Arabidopsis, the photoperiodic flowering pathway is controlled by a set of regulators that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f480a4aa26a0fede98a08c30dba02115
https://doi.org/10.1007/s00425-009-0958-7

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Mutations in CHLOROPLAST RNA BINDING provide evidence for the involvement of the chloroplast in the regulation of the circadian clock in Arabidopsis

Autor: Yael Harir, Ido Kron, Shai Yerushalmi, Miriam Hassidim, Nir Keren, Dror Hilman, David Fradkin, Esther Yakir, Rachel M. Green

Publikováno v: The Plant Journal. 51:551-562

*Summary The Arabidopsis circadian system regulates the expression of up to 36% of the nuclear genome, including many genes that encode photosynthetic proteins. The expression of nuclear-encoded photosynthesis genes is also regulated by signals from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce490a9c785ae95577e72180b6119ed4
https://doi.org/10.1111/j.1365-313x.2007.03160.x

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Regulation of output from the plant circadian clock

Autor: Yael Harir, Esther Yakir, Rachel M. Green, Dror Hilman

Publikováno v: FEBS Journal. 274:335-345

Plants, like many other organisms, have endogenous biological clocks that enable them to organize their physiological, metabolic and developmental processes so that they occur at optimal times. The best studied of these biological clocks are the circ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d9284b035b5a7015c54e299f1111ee1
https://doi.org/10.1111/j.1742-4658.2006.05616.x

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