Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers

Autor: Raj Kumar Sadhu, Christian Hernandez-Padilla, Yael Eshed Eisenbach, Samo Penič, Lixia Zhang, Harshad D. Vishwasrao, Bahareh Behkam, Konstantinos Konstantopoulos, Hari Shroff, Aleš Iglič, Elior Peles, Amrinder S. Nain, Nir S. Gov

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Protrusions at the leading-edge of a cell play an important role in sensing the extracellular cues during cellular spreading and motility. Recent studies provided indications that these protrusions wrap (coil) around the extracellular fibers

Externí odkaz: https://doaj.org/article/c56bd7d4832343bf8d4dfb5fdae7a92e

Membrane-bound complement regulator expression in peripheral nerves

Autor: Netanel Karbian, Yael Eshed-Eisenbach, Marian Zeibak, Adi Tabib, Natasha Sukhanov, Anya Vainshtein, B. Paul Morgan, Yakov Fellig, Elior Peles, Dror Mevorach

BACKGROUND: Homozygous CD59-deficient patients manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), hemolytic anemia and recurrent strokes. Variable mutations in CD59, leading to loss of function, have been describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce0250eb60244b79201ba3dde564b494
https://doi.org/10.21203/rs.3.rs-2738481/v1

LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period

Autor: Nina Kozar-Gillan, Atanaska Velichkova, George Kanatouris, Yael Eshed-Eisenbach, Gavin Steel, Martine Jaegle, Eerik Aunin, Elior Peles, Carole Torsney, Dies N. Meijer

Publikováno v: The Journal of cell biology, 222(4):e202211031. Rockefeller University Press
Kozar, N, Velichkova, A, Kanatouris, G, Eshed-Eisenbach, Y, Steel, G, Jaegle, M, Aunin, E, Peles, E, Torsney, C & Meijer, D 2023, ' LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period ', Journal of Cell Biology, vol. 222, no. 4, e202211031 . https://doi.org/10.1083/jcb.202211031

Along myelinated axons, Shaker-type potassium channels (Kv1) accumulate at high density in the juxtaparanodal region, directly adjacent to the paranodal axon–glia junctions that flank the nodes of Ranvier. However, the mechanisms that control the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20740a02bda5b79dd18d06d624dd193
https://pure.eur.nl/en/publications/b8ed7bf3-f7b0-4c6f-b264-3772c0b53981

A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement

Autor: Diana Castro, Mary M. Reilly, Steve Courel, Amit Abraham, Lisa Abreu, Chelsea Bacon, Gal Shner, Ramin Shiekhattar, Yael Eshed-Eisenbach, Anna Vainshtein, Andrea Cortese, Elior Peles, Michael E. Shy, Elena Buglo, Yunhong Bai, Gabriel Gaidosh, Stephan Züchner, Adriana P. Rebelo, Vladimir Camarena, Dennis K. Burns, Shawna M. E. Feely

Publikováno v: Brain. 144:1197-1213

The CADM family of proteins consists of four neuronal specific adhesion molecules (CADM1, CADM2, CADM3 and CADM4) that mediate the direct contact and interaction between axons and glia. In the peripheral nerve, axon-Schwann cell interaction is essent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::566cad80b83eba4923d381a9a83e7c12
https://doi.org/10.1093/brain/awab019

Coiling of cellular protrusions around extracellular fibers

Autor: Raj Kumar Sadhu, Christian Hernandez-Padilla, Yael Eshed Eisenbach, Lixia Zhang, Harshad D Vishwasrao, Bahareh Behkam, Hari Shroff, Aleš Iglič, Elior Peles, Amrinder S. Nain, Nir S Gov

Protrusions at the leading-edge of a cell play an important role in sensing the extracellular cues, during cellular spreading and motility. Recent studies provided indications that these protrusions wrap (coil) around the extra-cellular fibers. The d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04f6312638f9fc486a11fb1ea329a66