Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Yael, Alippe"'
Autor:
Natasha M. Kafai, Hana Janova, Matthew D. Cain, Yael Alippe, Stefanie Muraro, Alan Sariol, Michelle Elam-Noll, Robyn S. Klein, Michael S. Diamond
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112946- (2023)
Summary: Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) is a recently reported en
Externí odkaz:
https://doaj.org/article/128a62baae2949b18c6c14e4e103cc19
IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response that does not encompass a massive immune cell infiltration yet contributes to cartilage degradation and loss of joint mobility, suggesting a chondrocyt
Externí odkaz:
https://doaj.org/article/21365e45f0c64be1ab2a0821cd13c1e2
Autor:
Glennys V. Reynoso, David N. Gordon, Anurag Kalia, Cynthia C. Aguilar, Courtney S. Malo, Maya Aleshnick, Kimberly A. Dowd, Christian R. Cherry, John P. Shannon, Sophia M. Vrba, Autumn C. Holmes, Yael Alippe, Sonia Maciejewski, Kenichi Asano, Michael S. Diamond, Theodore C. Pierson, Heather D. Hickman
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112126- (2023)
Summary: To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of myeloid cells, in particular monocytes and dendritic cells. However, the timing and mechanisms underlying shuttling of the virus by immune cells remains
Externí odkaz:
https://doaj.org/article/1e565ee0ec8c4a429c99464dca821ac4
Autor:
Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen, Gabriel Mbalaviele
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-IL-18 into bioactive
Externí odkaz:
https://doaj.org/article/85e85314d3ee434fb76113941a98d1d4
Autor:
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J Silva, Jie Shen, Gabriel Mbalaviele
Publikováno v:
eLife, Vol 11 (2022)
Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM-mediated pore formation can compromise the integrity of the plasma mem
Externí odkaz:
https://doaj.org/article/7ca9264616784893a0c9e2f16bce0ef6
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L Kostecki, Joseph B Monahan, Deborah J Veis, Yousef Abu-Amer, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000807 (2020)
Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Here, we use the syngeneic mouse BMT model to te
Externí odkaz:
https://doaj.org/article/dfcc01b5a9e84be9b30dca2343479fa0
Autor:
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V. Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer ti
Externí odkaz:
https://doaj.org/article/f52ad37df2334b81a1175e640425d4a4
Autor:
Chun Wang, Can-Xin Xu, Yael Alippe, Chao Qu, Jianqiu Xiao, Ernestina Schipani, Roberto Civitelli, Yousef Abu-Amer, Gabriel Mbalaviele
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the hu
Externí odkaz:
https://doaj.org/article/13f4d71f788e4c60923f5962ac917d93
Autor:
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Canxin Xu, Dustin Kress, Roberto Civitelli, Yousef Abu-Amer, Thirumala-Devi Kanneganti, Daniel C Link, Gabriel Mbalaviele
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e3000047 (2018)
Mutated NLRP3 assembles a hyperactive inflammasome, which causes excessive secretion of interleukin (IL)-1β and IL-18 and, ultimately, a spectrum of autoinflammatory disorders known as cryopyrinopathies of which neonatal-onset multisystem inflammato
Externí odkaz:
https://doaj.org/article/266b07cae49e41b7aebe6122e5a1256f
Autor:
Chun Wang, L. Yuan, Matthew J. Silva, Michael D. Brodt, Yousef Abu-Amer, Tong Yang, Jie Shen, Kai Sun, H. Hu, Jianqiu Xiao, Gabriel Mbalaviele, Yael Alippe, D. Hao
Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM- mediated pore formation can compromise the integrity of the plasma me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033eb685aa388c0b3336f9a2d7a1f49c
https://doi.org/10.1101/2021.11.29.470391
https://doi.org/10.1101/2021.11.29.470391
