Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yadunanda Kumar"'
Autor:
Yadunanda Kumar, Cui Liang, Gino V Limmon, Li Liang, Bevin P Engelward, Eng Eong Ooi, Jianzhu Chen, Steven R Tannenbaum
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86912 (2014)
BACKGROUND: Management of influenza, a major contributor to the worldwide disease burden, is complicated by lack of reliable methods for early identification of susceptible individuals. Identification of molecular markers that can augment existing di
Externí odkaz:
https://doaj.org/article/180ac5208efc4156834fbea666675ca9
Autor:
Liang Cui, Yie Hou Lee, Yadunanda Kumar, Fengguo Xu, Kun Lu, Eng Eong Ooi, Steven R Tannenbaum, Choon Nam Ong
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 8, p e2373 (2013)
Dengue virus (DENV) is the most widespread arbovirus with an estimated 100 million infections occurring every year. Endemic in the tropical and subtropical areas of the world, dengue fever/dengue hemorrhagic fever (DF/DHF) is emerging as a major publ
Externí odkaz:
https://doaj.org/article/20725333639749699940252b3fbcf375
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1887 (2012)
BACKGROUND: Infections caused by dengue virus are a major cause of morbidity and mortality in tropical and subtropical regions of the world. Factors that control transition from mild forms of disease such as dengue fever (DF) to more life-threatening
Externí odkaz:
https://doaj.org/article/d378f76ca40843fab96451a6fe4744c4
Autor:
Choon Nam Ong, Jianzhu Chen, Yie Hou Lee, Steven R. Tannenbaum, Wanxing Eugene Ho, Tze Khee Chan, Dahai Zheng, Yadunanda Kumar, Liang Cui
Publikováno v:
Scientific Reports
Influenza virus infection (IVI) can cause primary viral pneumonia, which may progress to acute lung injury (ALI) and respiratory failure with a potentially fatal outcome. At present, the interactions between host and influenza virus at molecular leve
Autor:
Yi-Shan Chen, Hector Alex Saka, Yadunanda Kumar, Laura G. Dubois, J. Will Thompson, M. Arthur Moseley, Raphael H. Valdivia
Publikováno v:
Molecular Microbiology. 82:1185-1203
Chlamydia trachomatis is an obligate intracellular pathogen responsible for ocular and genital infections of significant public health importance. C. trachomatis undergoes a biphasic developmental cycle alternating between two distinct forms: the inf
Autor:
Yadunanda Kumar, Raphael H. Valdivia
Publikováno v:
Cell Host & Microbe. 5(6):593-601
A large number of intracellular pathogens survive in vacuolar niches composed of host-derived membranes modified extensively by pathogen proteins and lipids. Although intracellular lifestyles offer protection from humoral immune responses, vacuole-bo
Autor:
Raphael H. Valdivia, Yadunanda Kumar
Publikováno v:
Cell Host & Microbe. 4(2):159-169
Chlamydia trachomatis replicates within a large vacuole (“inclusion”) that sequesters bacterial components from direct contact with the host cytoplasm. Here, we report that the inclusion is encased in a network of F-actin and intermediate filamen
Autor:
Elizabeth R. Fischer, Yadunanda Kumar, Ted Hackstadt, Jordan L. Cocchiaro, Raphael H. Valdivia
Publikováno v:
Proceedings of the National Academy of Sciences. 105:9379-9384
The acquisition of host-derived lipids is essential for the pathogenesis of the obligate intracellular bacteria Chlamydia trachomatis . Current models of chlamydial lipid acquisition center on the fusion of Golgi-derived exocytic vesicles and endosom
Publikováno v:
Current Biology. 16(16):1646-1651
SummaryLipid droplets (LDs) are ubiquitous but poorly understood neutral-lipid-rich eukaryotic organelles that may participate in functions as diverse as lipid homeostasis, membrane traffic, and signaling [1]. We report that infection with the obliga
Publikováno v:
Molecular Microbiology. 60:51-66
Our understanding of how obligate intracellular pathogens co-opt eukaryotic cellular functions has been limited by their intractability to genetic manipulation and by the abundance of pathogen-specific genes with no known functional homologues. In th