Sensitive tumour detection and classification using plasma cell-free DNA methylomes

Autor: Zhen Zhao, Tiantian Li, Anna Goldenberg, Olena Kis, John Douglas Mcpherson, Tiago Medina, Jessica Liu, Mark Mansour, Scott V. Bratman, Signy Chow, Rayjean J. Hung, Neil E. Fleshner, Ayelet Borgida, Philippe L. Bedard, Mark D. Minden, Trevor J. Pugh, Yadon Wang, Anna Spreafico, Gordon Fehringer, Steven Gallinger, Michael H.A. Roehrl, Zhuo Chen, Rajat Singhania, Ankur Chakravarthy, David Roulois, Andrea Arruda, Michael M. Hoffman, Ilias Ettayebi, Geoffrey Liu, Ting Ting Wang, Natasha B. Leighl, Tracy Murphy, Catherine A. O’Brien, Dianne Chadwick, Philip C. Zuzarte, Grainne M. O'Kane, Shu Yi Shen, Daniel D. De Carvalho

Publikováno v: Nature
Nature, Nature Publishing Group, 2018, 563 (7732), pp.579-583. ⟨10.1038/s41586-018-0703-0⟩
Nature, 2018, 563 (7732), pp.579-583. ⟨10.1038/s41586-018-0703-0⟩

The use of liquid biopsies for cancer detection and management is rapidly gaining prominence1. Current methods for the detection of circulating tumour DNA involve sequencing somatic mutations using cell-free DNA, but the sensitivity of these methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7dcbbaf3e968ca094b955d13d9e0d5
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01974928