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Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.

Autor: Jin Q; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Gutierrez Diaz B; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Pieters T; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Zhou Y; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Narang S; Department of Pathology, New York University School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., Fijalkwoski I; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Borin C; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Van Laere J; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium., Payton M; Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Cho BK; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Han C; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Sun L; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Serafin V; Oncohematology Laboratory, Department of Women's and Children's Health, University of Padova, Padova, Italy.; Department of Surgery Oncology and Gastroenterology, Oncology and Immunology Section, University of Padova, Padova, Italy., Yacu G; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA., Von Loocke W; Department of Pathology, New York University School of Medicine, New York, NY, USA., Basso G; Oncohematology Laboratory, Department of Women's and Children's Health, University of Padova, Padova, Italy.; Department of Surgery Oncology and Gastroenterology, Oncology and Immunology Section, University of Padova, Padova, Italy., Veltri G; Oncohematology Laboratory, Department of Women's and Children's Health, University of Padova, Padova, Italy., Dreveny I; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Goo YA; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Safgren SL; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Tsai YC; University Children's Hospital, Division of Pediatric Oncology, University of Zurich, Zurich, Switzerland., Bornhauser B; University Children's Hospital, Division of Pediatric Oncology, University of Zurich, Zurich, Switzerland., Suraneni PK; Department of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA., Gaspar-Maia A; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Kandela I; Center for Developmental Therapeutics, Northwestern University, Evanston, IL, USA., Van Vlierberghe P; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Crispino JD; Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tsirigos A; Department of Pathology, New York University School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., Ntziachristos P; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.

Publikováno v: Science advances [Sci Adv] 2022 Dec 09; Vol. 8 (49), pp. eabq8437. Date of Electronic Publication: 2022 Dec 09.