Výsledky vyhledávání - "Yacov Goshen"

Telomere length is a prognostic factor in neuroblastoma

Autor: Yacov Goshen, Drorit Luria, Isaac Yaniv, Anat Ohali, Smadar Avigad, Meora Feinmesser, Shifra Ash, Rina Zaizov

Publikováno v: Cancer. 107:1391-1399

BACKGROUND. Maintenance of telomeres, in most instances by reactivation of telomerase, is obligatory for the indefinite proliferation of tumor cells. The objective of this study was to evaluate telomere length and telomerase activity (TA) as markers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46efb24678e68a13178592504fc33ecb
https://doi.org/10.1002/cncr.22132

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Prenatal Diagnosis in Li-Fraumeni Syndrome

Autor: Hadar Benyaminy, Smadar Avigad, Isaac Yaniv, Rina Zaizov, Dalit Barel, Dan Peleg, Noa Ben-Baruch, Yacov Goshen, Mordechai Shohat, Ian J. Cohen, Ellen Taub

Publikováno v: Journal of Pediatric Hematology/Oncology. 26:541-545

The hallmark of Li-Fraumeni syndrome (LFS), a familial cancer syndrome, is constitutional TP53 mutation. The authors addressed the complex question of predictive prenatal genetic testing for cancer risk associated with inheritance of TP53 mutation.A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e4bb8e6d752cc0bc1f179d18baab26
https://doi.org/10.1097/01.mph.0000139452.45209.ad

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Classical and molecular cytogenetic abnormalities and outcome of childhood acute myeloid leukaemia: report from a referral centre in Israel

Autor: David M. Steinberg, Irit Bar-Am, Marta Jeison, Ian J. Cohen, Yacov Goshen, Jerry Stein, Isaac Yaniv, Batia Stark, Rina Zaizov, Gavriel Herzel, Dalia Sthoeger, Jacques Mardoukh, Drorit Luria, Gali Avrahami, Leticia Glazer Gabay, Yossef Kapeliushnik

Publikováno v: British Journal of Haematology. 126:320-337

Summary The incidence of cytogenetic abnormalities in childhood de novo acute myeloid leukaemia (AML) and its prognostic significance was assessed in an Israeli paediatric referral centre. Cytogenetic analysis was successful in 86 of 97 children (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63629df88881c02d21b1dd2853b8b755
https://doi.org/10.1111/j.1365-2141.2004.05038.x

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The predictive potential of molecular detection in the nonmetastatic Ewing family of tumors

Autor: Rina Zaizov, Yehuda Kollender, Ella Liberzon, Smadar Avigad, I Yaniv, Josephine Issakov, Ian J. Cohen, Yacov Goshen, Shifra Ash, Julia Zilberstein, Isaac Meller

Publikováno v: Cancer. 100:1053-1058

BACKGROUND Tumors in the Ewing family (EFTs) are the second most common bone tumors in children and adolescents. Despite aggressive chemotherapy, one-third of patients with localized tumor still may develop recurrences. This implies that not all tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d221621abce0837f124d822ffa7203
https://doi.org/10.1002/cncr.20059

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Pregnancy outcome in women treated with doxorubicin for childhood cancer

Autor: Jacob Bar, Ofer Davidi, Rafael Hirsch, Yacov Goshen, Moshe Hod, Itzhak Yaniv

Publikováno v: American Journal of Obstetrics and Gynecology. 189:853-857

Pregnancy outcome and the effect of pregnancy on cardiac function were assessed in women cured of childhood cancer.Forty women who received doxorubicin as part of a chemotherapy protocol for a neoplastic disorder in childhood were followed up at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c55fde7894f242f797ac3ed022af22a
https://doi.org/10.1067/s0002-9378(03)00837-8

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Involvement of 11p15 and 3q21q26 in therapy-related myeloid leukemia (t-ML) in children

Autor: Batia Stark, Ruth Vogel, Rina Zaizov, Mordechai Shohat, Ian J. Cohen, Marta Jeison, Chaim Kaplinsky, I. Yaniv, Yacov Goshen

Publikováno v: Cancer Genetics and Cytogenetics. 75:11-22

The cytogenetic findings of therapy-related myeloid leukemia (t-ML) in three children are presented. These included one male patient with acute lymphoblastic leukemia (ALL) who underwent bone marrow transplantation and developed therapy-related myelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60761397c8f5875fbb35579c5bef5092
https://doi.org/10.1016/0165-4608(94)90209-7

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2p24 Gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma: biological and clinical characteristics

Autor: Marta, Jeison, Shifra, Ash, Gili, Halevy-Berko, Jacques, Mardoukh, Drorit, Luria, Smadar, Avigad, Galina, Feinberg-Gorenshtein, Yacov, Goshen, Gabriel, Hertzel, Joseph, Kapelushnik, Ayelet, Ben Barak, Dina, Attias, Ran, Steinberg, Jerry, Stein, Batia, Stark, Isaac, Yaniv

Publikováno v: The American journal of pathology. 176(6)

Although the role of MYCN amplification in neuroblastoma is well established, the biological and clinical characteristics of the 2p gain region harboring the MYCN gene remain unclear. The aim of this study was to compare the biological and clinical c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98679ced338a149f1bed6fe890f3f6c0
https://pubmed.ncbi.nlm.nih.gov/20395439

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Different telomere maintenance mechanisms in alveolar and embryonal rhabdomyosarcoma

Autor: Inna Naumov, Yacov Goshen, Smadar Avigad, Anat Ohali, Isaac Yaniv, Shifra Ash

Publikováno v: Genes, chromosomescancer. 47(11)

The activation of a telomere maintenance mechanism (TMM) is crucial for the immortalization of tumor cells. Most human cancers apply telomerase-dependent TMM but some use a mechanism called alternative lengthening of telomeres (ALT). The latter was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23941361d8cf53f144614df2c95be8b2
https://pubmed.ncbi.nlm.nih.gov/18663749

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High incidence of meningioma in cranial irradiated survivors of childhood acute lymphoblastic leukemia

Autor: Meora Feinmesser, Batia Stark, Liora Kornreich, Isaac Yaniv, Shalom Michowiz, Yacov Goshen

Publikováno v: Pediatric bloodcancer. 49(3)

Background Most survivors of childhood acute lymphoblastic leukemia (ALL) and T-cell lymphoma (T-NHL) treated before 1990 received cranial radiation. This study assessed the occurrence of second tumors in irradiated and non-irradiated survivors. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d55721c6ccb02c394b78dc5ecf8ac7d
https://pubmed.ncbi.nlm.nih.gov/17243137

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