Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yacob Gomez Llorente"'
Autor:
Scott A. Hollingsworth, Cameron L. Noland, Karin Vroom, Anasuya Saha, Miranda Sam, Qinshan Gao, Haihong Zhou, David U. Grandy, Sujata Singh, Zhiyun Wen, Christopher Warren, Xiaohong Shirley Ma, Daniel Malashock, Jennifer Galli, Gwenny Go, Michael Eddins, Todd Mayhood, Karthik Sathiyamoorthy, Arthur Fridman, Fahimeh Raoufi, Yacob Gomez-Llorente, Andrea Patridge, Yinyan Tang, Shi-Juan Chen, Marc Bailly, Chengjie Ji, Laura J. Kingsley, Alan C. Cheng, Bernhard H. Geierstanger, Daniel M. Gorman, Lan Zhang, Kalyan Pande
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not only to prevent and treat COVID-19
Externí odkaz:
https://doaj.org/article/a9d7ab42a9cb4a6cb05bac47eef92301
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d6d3fdb3039843b9b530ac94e6eb34d2
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of
Externí odkaz:
https://doaj.org/article/12bfc20a079d44f5b507280558359df6
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of thes
Externí odkaz:
https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be6
Autor:
Yacob Gomez-Llorente, Fady Jebara, Malay Patra, Radhika Malik, Shahar Nisemblat, Orna Chomsky-Hecht, Avital Parnas, Abdussalam Azem, Joel A. Hirsch, Iban Ubarretxena-Belandia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key interme
Externí odkaz:
https://doaj.org/article/350b4f4502ee4f4abafe17203699bcde
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Ghassan N. Fayad, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/15828ecf3c6a4e49a73581c4631d3a3d
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :1-32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::208140ee7532da413367a243c51459b2
https://doi.org/10.1002/0471266949.bmc266
https://doi.org/10.1002/0471266949.bmc266
Autor:
Iban Ubarretxena-Belandia, Mykhailo Kopylov, Louise Prakash, Robert E. Johnson, Radhika Malik, Satya Prakash, Aneel K. Aggarwal, Rinku Jain, Yacob Gomez-Llorente
Publikováno v:
Nature structural & molecular biology
DNA polymerase ζ (Polζ) belongs to the same B-family as high-fidelity replicative polymerases, yet is specialized for the extension reaction in translesion DNA synthesis (TLS). Despite its importance in TLS, the structure of Polζ is unknown. We pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7525781a7907007630126d95c37f79d1
https://doi.org/10.1038/s41594-020-0476-7
https://doi.org/10.1038/s41594-020-0476-7
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature communications. 13(1)
Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of injectab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1b1ab72351f303daeb431c6316f1a1
https://pubmed.ncbi.nlm.nih.gov/35177603
https://pubmed.ncbi.nlm.nih.gov/35177603
Autor:
Laurence Fayadat-Dilman, Jennifer O'Neil, Hussam Hisham Shaheen, Ghassan N. Fayad, Heping Lin, S. Shane Taremi, Giovanna Scapin, Corey Strickland, Heiko Greb, Nhung Nguyen, Symon Gathiaka, Mas Handa, Daniel Cipriano, Rachel L. Palte, Brian Hall, Eric Sterner, Veronica Juan, Esther Kofman, Xun Chen, Kalyan Chakravarthy, Yacob Gomez-Llorente, Mark Hsieh, J. Richard Miller, Angie Sun, Marc Andre Bailly
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of l-arginine to l-ornithine and urea, and modulates T-cell-mediated immune response. Arginase-targeted therapies have been pursued across several disease areas including immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9236021a6a0eb417fbe5a119ad6b9d7a
https://doi.org/10.1038/s42003-021-02444-z
https://doi.org/10.1038/s42003-021-02444-z