Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yachun Guo"'
Publikováno v:
Molecules, Vol 29, Iss 18, p 4448 (2024)
Compound 1 was previously identified by our team as a glycogen phosphorylase (GP) inhibitor with glucose-lowering activity and demonstrated to have protective effects against myocardial and cerebral ischemia. However, its impact on muscle function ha
Externí odkaz:
https://doaj.org/article/243db1475d444b6588c5d4e4b89a4582
Publikováno v:
Molecules, Vol 28, Iss 4, p 1697 (2023)
Brain-type glycogen phosphorylase (PYGB) inhibitors are recognized as prospective drugs for treating ischemic brain injury. We previously reported compound 1 as a novel glycogen phosphorylase inhibitor with brain-protective properties. In this study,
Externí odkaz:
https://doaj.org/article/935eb63c7ba447b0b6a9148416f81fa0
Publikováno v:
Molecules, Vol 27, Iss 19, p 6333 (2022)
Brain-type glycogen phosphorylase inhibitors are potential new drugs for treating ischemic brain injury. In our previous study, we reported compound 1 as a novel brain-type glycogen phosphorylase inhibitor with cardioprotective properties. We also fo
Externí odkaz:
https://doaj.org/article/59887175a02c446aa59b38c34db64c9f
Publikováno v:
Future Medicinal Chemistry. 15:587-597
Aim: To evaluate the effects of a novel glycogen phosphorylase inhibitor (NGPI) on cerebral ischemia–reperfusion injury (CIRI). Methods: Cerebral ischemia was induced in mice using a modified bilateral common carotid artery ligation model. To asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11cf290f257c3951515ef3fb323e1d9b
https://doi.org/10.4155/fmc-2023-0038
https://doi.org/10.4155/fmc-2023-0038
Publikováno v:
Russian Journal of Bioorganic Chemistry. 48:589-595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc13d241babffddedfdc54a85cf2497
https://doi.org/10.1134/s1068162022030232
https://doi.org/10.1134/s1068162022030232
Akademický článek
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Publikováno v:
Future medicinal chemistry. 14(21)
Background: Owing to the chronic nature of Type 2 diabetes mellitus, antidiabetic drugs must have long-lasting efficacy. Compound 1 has a good inhibitory effect on acute hyperglycemia, but its long-term hypoglycemic effect has not been evaluated. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96458e7fbd23579c70707854df7002a1
https://pubmed.ncbi.nlm.nih.gov/36106605
https://pubmed.ncbi.nlm.nih.gov/36106605
Publikováno v:
Journal of the Chinese Medical Association. 82:202-208
This study was conducted to investigate the treatment efficacies and immunological mechanisms of action of dioscin in mice with chicken collagen type II-induced arthritis (CIA).The CIA mice was randomly divided into the model group (M), dioscin group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33ff47fd75e998d8670d7c7dccb0147
https://doi.org/10.1097/jcma.0000000000000029
https://doi.org/10.1097/jcma.0000000000000029
Publikováno v:
Future medicinal chemistry. 13(10)
Glycogen phosphorylase (GP) is a key enzyme of glycogen catabolism, so it is significant to discover a new GP inhibitor. A series of benzazepinone derivatives were discovered as GP inhibitors with potent activity. Among these derivatives, compound 5d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0784b7513551a983e61ea9acd2693a2d
https://pubmed.ncbi.nlm.nih.gov/33906369
https://pubmed.ncbi.nlm.nih.gov/33906369
Autor:
Xiujun Liang, Mi Wang, Enhong Xing, Gao An, Hongru Song, Yachun Guo, Xiaofei Zhao, Guiying Feng
Publikováno v:
International Immunopharmacology. 39:79-83
The aim of this study was to detect the therapeutic effect of dioscin on collagen-induced arthritis (CIA). Mice model of CIA was induced by chicken collagen II and arthritis index was assessed. After suspension of dioscin (100mg/kg/d) or triptolide w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2dabd51444a8cc0d319ac82fd4432a
https://doi.org/10.1016/j.intimp.2016.06.029
https://doi.org/10.1016/j.intimp.2016.06.029