In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design¹

Autor: Costanzo, M. J., Almond, H. R., Jr., Hecker, L. R., Schott, M. R., Yabut, S. C., Zhang, H.-C., Andrade-Gordon, P., Corcoran, T. W., Giardino, E. C., Kauffman, J. A., Lewis, J. M., Garavilla, L. de, Haertlein, B. J., Maryanoff, B. E.

Publikováno v: Journal of Medicinal Chemistry; March 2005, Vol. 48 Issue: 6 p1984-2008, 25p

Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308

Autor: Hoekstra, W. J., Maryanoff, B. E., Damiano, B. P., Andrade-Gordon, P., Cohen, J. H., Costanzo, M. J., Haertlein, B. J., Hecker, L. R., Hulshizer, B. L., Kauffman, J. A., Keane, P., McComsey, D. F., Mitchell, J. A., Scott, L., Shah, R. D., Yabut, S. C.

Publikováno v: Journal of Medicinal Chemistry; December 16, 1999, Vol. 42 Issue: 25 p5254-5265, 12p

Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308.

Autor: Hoekstra WJ; Drug Discovery and New Product Research, The R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA. whoekstr@prius.jnj.com, Maryanoff BE, Damiano BP, Andrade-Gordon P, Cohen JH, Costanzo MJ, Haertlein BJ, Hecker LR, Hulshizer BL, Kauffman JA, Keane P, McComsey DF, Mitchell JA, Scott L, Shah RD, Yabut SC

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1999 Dec 16; Vol. 42 (25), pp. 5254-65.