Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yaakov Maman"'
Autor:
Shira Perez, Anat Lavi-Itzkovitz, Moriah Gidoni, Tom Domovitz, Roba Dabour, Ishant Khurana, Ateret Davidovich, Ana Tobar, Alejandro Livoff, Evgeny Solomonov, Yaakov Maman, Assam El-Osta, Yishan Tsai, Ming-Lung Yu, Salomon M. Stemmer, Izhak Haviv, Gur Yaari, Meital Gal-Tanamy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 1, Pp 63-81 (2023)
Background & Aims: Hepatocellular carcinoma (HCC) is a model of a diverse spectrum of cancers because it is induced by well-known etiologies, mainly hepatitis C virus (HCV) and hepatitis B virus. Here, we aimed to identify HCV-specific mutational sig
Externí odkaz:
https://doaj.org/article/2504d44cdec5437d864285de9108428c
Autor:
Tom Domovitz, Samer Ayoub, Michal Werbner, Joel Alter, Lee Izhaki Tavor, Yfat Yahalom-Ronen, Evgeny Tikhonov, Tomer Meirson, Yaakov Maman, Nir Paran, Tomer Israely, Moshe Dessau, Meital Gal-Tanamy
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Recent studies suggest the enhancement of liver injury in COVID-19 patients infected with Hepatitis C virus (HCV). Hepatocytes express low levels of angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor, raising the possibili
Externí odkaz:
https://doaj.org/article/7a83e1314cde4b69ba8f3d17ef7f1be6
Autor:
Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A. Deshpande, Yaakov Maman, Amanda Day, Tanya T. Paull, André Nussenzweig
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that th
Externí odkaz:
https://doaj.org/article/fe2f3dab8f70455daf145802e93451d5
Autor:
Filip Senigl, Yaakov Maman, Ravi K. Dinesh, Jukka Alinikula, Rashu B. Seth, Lubomira Pecnova, Arina D. Omer, Suhas S.P. Rao, David Weisz, Jean-Marie Buerstedde, Erez Lieberman Aiden, Rafael Casellas, Jiri Hejnar, David G. Schatz
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3902-3915.e8 (2019)
Summary: Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible
Externí odkaz:
https://doaj.org/article/2f5ff53bf6664a26b0aa7baa83fb62a9
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4471-4481.e6 (2019)
Summary: During V(D)J recombination, RAG proteins introduce DNA double-strand breaks (DSBs) at recombination signal sequences (RSSs) that contain either 12- or 23-nt spacer regions. Coordinated 12/23 cleavage predicts that DSBs at variable (V) gene s
Externí odkaz:
https://doaj.org/article/a1e8094285d54d789abfc581dd8180cc
Autor:
Alina Tarsalainen, Anni Soikkeli, Frederic W Alt, Minna K. Kyläniemi, Jessica J. McDonald, David G. Schatz, Fei-Long Meng, Paulina Budzynska, Yaakov Maman, Filip Šenigl, Jukka Alinikula
Publikováno v:
The Journal of Immunology. 208:143-154
Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by their enhancers (diversification activators [DIVACs]), but how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c91f543478d6fab77a04f04c4c9518
https://doi.org/10.4049/jimmunol.2100923
https://doi.org/10.4049/jimmunol.2100923
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149146 (2016)
The activation induced cytosine deaminase (AID) mediates diversification of B cell immunoglobulin genes by the three distinct yet related processes of somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion (GCV). SHM occur
Externí odkaz:
https://doaj.org/article/da2821501e8f40e6b203a4335d12800f
Autor:
David G. Schatz, Alina Tarsalainen, Minna K. Kyläniemi, Jessica J. McDonald, Frederic W. Alt, Fei-Long Meng, Jukka Alinikula, Paulina Budzynska, Anni Soikkeli, Yaakov Maman, Filip Šenigl
Somatic hypermutation (SHM) drives the genetic diversity of immunoglobulin (Ig) genes in activated B cells and supports the generation of antibodies with increased affinity for antigen. SHM is targeted to Ig genes by their enhancers (DIVACs; diversif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11723cc05ee32f54f7d25f8aa598c6e4
https://doi.org/10.1101/2021.09.16.460442
https://doi.org/10.1101/2021.09.16.460442
Autor:
Yaakov Maman, Michael E. Ward, Heather Baldwin, Eunice Domínguez-Martín, Jennifer Lippincott-Schwartz, Shireen A. Sarraf, Gil Kanfer, Kory R. Johnson, Martin Kampmann, Richard J. Youle
Publikováno v:
The Journal of Cell Biology
Kanfer et al. develop a pooled CRISPRi screening method to identify genes regulating intracellular protein localization, organelle morphology or other subcellular phenotypes. The method uses machine learning to identify genetically altered cells, a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff45bb3b57d433e0362018972e59f91
https://doi.org/10.1083/jcb.202006180
https://doi.org/10.1083/jcb.202006180
Autor:
Richard J. Youle, Heather Baldwin, Gil Kanfer, Michael E. Ward, Martin Kampmann, Kory R. Johnson, Yaakov Maman, Shireen A. Sarraf, Jennifer Lippincott-Schwartz
Genome-wide CRISPR screens have transformed our ability to systematically interrogate human gene function, but are currently limited to a subset of cellular phenotypes. We report a novel pooled screening approach for a wider range of cellular and sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::024b9ce02c0347e6e6ed93bd1bb47fa5
https://doi.org/10.1101/2020.07.02.184390
https://doi.org/10.1101/2020.07.02.184390