Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Autor: Richard Laga, Robert A. Seder, Hidehiro Yamane, Nicolas J. Blobel, Yaakov Itzkowitz, Eliane Piaggio, Faezzah Baharom, Vincent L. Coble, Leonard W. Seymour, Brennan Decker, Olivier Lantz, Christine Sedlik, Ramiro A. Ramirez-Valdez, Justin Cheung, Joseph R. Francica, Geoffrey M. Lynn, Neeha Zaidi, Yaling Zhu, Sarah R. Nichols, Joshua D. Bernstock, Mateusz Maciejewski, Andrew S. Ishizuka, Joshua M. Gammon, Jordan Denizeau, Brian Francica, Christopher M. Jewell, Philippe De La Rochere, Charles G. Drake, Kennedy Tobin, Margery G. Smelkinson

Publikováno v: Nature Biotechnology
Nature Biotechnology, Nature Publishing Group, 2020, ⟨10.1038/s41587-019-0390-x⟩
Nature biotechnology
Nature Biotechnology, 2020, ⟨10.1038/s41587-019-0390-x⟩
Nature Biotechnology, Nature Publishing Group, 2020, Epub ahead of print. ⟨10.1038/s41587-019-0390-x⟩
Nature Biotechnology, 2020, Epub ahead of print. ⟨10.1038/s41587-019-0390-x⟩

International audience; Personalized cancer vaccines targeting patient-specific neoantigens are a promising cancer treatment modality; however, neoantigen physicochemical variability can present challenges to manufacturing personalized cancer vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644c10d50fa2842221d97056616010fc
https://www.hal.inserm.fr/inserm-02479477/document

The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure

Autor: Komal Sodhi, Yaakov Itzkowitz, Ariel Sher, Yosef D. Buchen, Nader G. Abraham, Joseph I. Shapiro, Joel Novograd, Zi Jian Xie

Publikováno v: Antioxidants
Antioxidants, Vol 9, Iss 1129, p 1129 (2020)

This review summarizes data from several laboratories that have demonstrated a role of the Na/K-ATPase, specifically its α1 subunit, in the generation of reactive oxygen species (ROS) via the negative regulator of Src. Together with Src and other si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6de23c843123715b6f06f715b43c429
https://doi.org/10.3390/antiox9111129