Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Yaakov Benenson"'
Autor:
Laura Prochazka, Yale S Michaels, Charles Lau, Ross D Jones, Mona Siu, Ting Yin, Diana Wu, Esther Jang, Mercedes Vázquez‐Cantú, Penney M Gilbert, Himanshu Kaul, Yaakov Benenson, Peter W Zandstra
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 11, Pp 1-22 (2022)
Abstract During development, cell state transitions are coordinated through changes in the identity of molecular regulators in a cell type‐ and dose‐specific manner. The ability to rationally engineer such transitions in human pluripotent stem ce
Externí odkaz:
https://doaj.org/article/e2b62297353c4d7b84600c9edd7e25df
Autor:
Simon Höllerer, Laetitia Papaxanthos, Anja Cathrin Gumpinger, Katrin Fischer, Christian Beisel, Karsten Borgwardt, Yaakov Benenson, Markus Jeschek
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Current methods to generate sequence-function data at large scale are either technically complex or limited to specific applications. Here the authors introduce DNA-based phenotypic recording to overcome these limitations and enable deep learning for
Externí odkaz:
https://doaj.org/article/5cdab11544394bd78e7fc3880bbaa8e2
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108437- (2020)
Summary: Multi-input logic gene circuits can enable sophisticated control of cell function, yet large-scale synthetic circuitry in mammalian cells has relied on post-transcriptional regulation or recombinase-triggered state transitions. Large-scale t
Externí odkaz:
https://doaj.org/article/1c1ecda421324a288cda07be3cebf015
Autor:
Christoph Stelzer, Yaakov Benenson
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008389 (2020)
The mapping of molecular inputs to their molecular outputs (input/output, I/O mapping) is an important characteristic of gene circuits, both natural and synthetic. Experimental determination of such mappings for synthetic circuits is best performed u
Externí odkaz:
https://doaj.org/article/901503ae8c2d45efae85919fe811d5b4
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 12, Pp 1-14 (2016)
Abstract Constructing gene circuits that satisfy quantitative performance criteria has been a long‐standing challenge in synthetic biology. Here, we show a strategy for optimizing a complex three‐gene circuit, a novel proportional miRNA biosensor
Externí odkaz:
https://doaj.org/article/e09b0d9487074365811966a0fcb6e756
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2525-2537 (2016)
One of the goals of synthetic biology is to develop programmable artificial gene networks that can transduce multiple endogenous molecular cues to precisely control cell behavior. Realizing this vision requires interfacing natural molecular inputs wi
Externí odkaz:
https://doaj.org/article/a7f2319b21554392866397309dbf2608
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Progress in drug discovery can be hampered by a limited exploration of chemical space and the difficulty in assessing the full range of drug candidates’ effects on living cells. Here the authors describe a cell-based assay to distinguish between of
Externí odkaz:
https://doaj.org/article/65aee4710469475e974f5ac63c44d69a
Autor:
Yaakov Benenson
Publikováno v:
CHIMIA, Vol 70, Iss 6 (2016)
Complexity in molecular systems can manifest itself either structurally or functionally. One of the more complex functions encountered in the natural world is that of information processing, or computation. Similarly, artificial cells will require th
Externí odkaz:
https://doaj.org/article/59eb007bb0a84b5eb3f1a14b70079f1f
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-12 (2011)
Abstract Natural and synthetic biological networks must function reliably in the face of fluctuating stoichiometry of their molecular components. These fluctuations are caused in part by changes in relative expression efficiency and the DNA template
Externí odkaz:
https://doaj.org/article/1ffdaa0621f74c7190909690d4b7636e
Autor:
Yaakov Benenson
Publikováno v:
Molecular Systems Biology, Vol 4, Iss 1, Pp 1-3 (2008)
Externí odkaz:
https://doaj.org/article/248a078d1b74406dbfb278cad70eda7a