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Akademický článek

Opioid-induced dysbiosis of maternal gut microbiota during gestation alters offspring gut microbiota and pain sensitivity

Autor: Yaa F. Abu, Salma Singh, Junyi Tao, Irina Chupikova, Praveen Singh, Jingjing Meng, Sabita Roy

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

ABSTRACTThere has been a rapid increase in neonates born with a history of prenatal opioid exposure. How prenatal opioid exposure affects pain sensitivity in offspring is of interest, as this may perpetuate the opioid epidemic. While few studies have

Externí odkaz: https://doaj.org/article/e6375a2ca15b42128978f745a78a2f6b

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Akademický článek

259 Eighty-six-fold increase in HIV diagnosis with 'Opt-out' Screening: Frontlines of Communities in the U.S. (FOCUS) Program in the UHealth Tower (UHT) Emergency Department (ED) - path to eliminate HIV transmission in the U.S.

Autor: Dushyantha Jayaweera, Yaa F. Abu, Barbara Huang, Emmanuel Thomas, David M. Lang, Tanira Ferreira, Kimar Estes, Monica Bahamon, Paula Pagan, Kira Villamizar, Kenneth A Scheppke

Publikováno v: Journal of Clinical and Translational Science, Vol 8, Pp 78-79 (2024)

OBJECTIVES/GOALS: Early HIV detection and treatment are key to reducing patient morbidity and mortality, yet 40% of people living with HIV do not know their status. “OPT-OUT” approaches to hiv testing, in which patients #_MSOCOM_1 are informed th

Externí odkaz: https://doaj.org/article/d115ea1ba4e940bc9c8f0c462520ef83

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Akademický článek

Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progression

Autor: Cora N. Betsinger, Joshua L. Justice, Matthew D. Tyl, Julia E. Edgar, Hanna G. Budayeva, Yaa F. Abu, Ileana M. Cristea

Publikováno v: mSystems, Vol 8, Iss 6 (2023)

ABSTRACT The ability to modulate host cell cycle progression is a requirement of many human viruses in order to facilitate their replication and propagation. Nuclear-replicating DNA viruses frequently stall the host cell cycle in G1 to avoid competit

Externí odkaz: https://doaj.org/article/ac8e958b01f1453089ef5b423bd68b82

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Opioid-induced microbial dysbiosis disrupts CPT-11 metabolism and increases gastrointestinal toxicity in a murine model

Autor: Jingjing Meng, Yaa F. Abu, Yue Zhang, Yuyin Zhou, Yun Xie, Yan Yan, Junyi Tao, Sundaram Ramakrishnan, Chi Chen, Sabita Roy

Publikováno v: British journal of pharmacology.

Opioids are commonly used for the management of cancer-associated pain and chemotherapy-induced diarrhea. The chemotherapeutic agent CPT-11 causes severe GI toxicity as a result of deconjugation of its inactive metabolite SN-38G by intestinal bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efa05dfdc29dc0676af72a99350b60f
https://pubmed.ncbi.nlm.nih.gov/36562107

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