Zobrazeno 1 - 10
of 138
pro vyhledávání: '"YaLing Hu"'
Autor:
Lin Zhang, Wenyuan Liu, Sufen Li, Jinjing Wang, Dalin Sun, Hui Li, Ziyuan Zhang, Yaling Hu, Jingai Fang
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0304365 (2024)
ObjectiveTo explore the molecular mechanism of Astragaloside IV (AS-IV) in alleviating renal fibrosis by inhibiting Urotensin II-induced pyroptosis and epithelial-mesenchymal transition of renal tubular epithelial cells.MethodsForty SD rats were rand
Externí odkaz:
https://doaj.org/article/5d2feea478654e29ba3bcb1ea05a38a2
Autor:
Jialei Hu, Yueyue Liu, Shuo Liu, Qun Shu, Xuenan Yang, Kai Chu, Yaping Qiao, Yaling Hu, Kaiqin Wang, Hongxing Pan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundUpdated vaccine strategies are needed to protect against new SARS-CoV-2 variants with increased immune escape. Here, information on the safety and immunogenicity of an inactivated Omicron-adapted vaccine is presented, as compared with Coron
Externí odkaz:
https://doaj.org/article/17358ec303714129a1df0acb81fae65a
Autor:
Daxing Xu, Wei Qian, Zhenkun Yang, Zhenhao Zhang, Ping Sun, Quan Wan, Ying Yin, Yaling Hu, Lingli Gong, Bo Zhang, Xusheng Yang, Zhening Pu, Peihua Lu, Jian Zou
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107003- (2023)
Summary: TP53 mutations are ubiquitous with tumorigenesis in non-small cell lung cancers (NSCLC). By analyzing the TCGA database, we reported that TP53 missense mutations are correlated with chromosomal instability and tumor mutation burden in NSCLC.
Externí odkaz:
https://doaj.org/article/f87bc9c161a54f9c9c552b2f70178445
Autor:
Lunhao Chen, Yaling Hu, Siyuan Wang, Kelei Cao, Weihao Mai, Weilin Sha, Huan Ma, Ling-Hui Zeng, Zhen-Zhong Xu, Yong-Jing Gao, Shumin Duan, Yue Wang, Zhihua Gao
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Neuropathic pain is a refractory condition that involves de novo protein synthesis in the nociceptive pathway. The mTOR is a master regulator of protein translation; however, mechanisms underlying its role in neuropathic pain remain elusive. Using th
Externí odkaz:
https://doaj.org/article/8424807da006498198accf9ed231d64c
Autor:
Yaling Hu, Bo Zhang, Peihua Lu, Jingying Wang, Cheng Chen, Ying Yin, Quan Wan, Jingjing Wang, Jiantong Jiao, Xiangming Fang, Zhening Pu, Lingli Gong, Li Ji, Lingpeng Zhu, Rui Zhang, Jia Zhang, Xusheng Yang, Qing Wang, Zhaohui Huang, Jian Zou
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Abstract Background NF‐κB signaling is widely linked to the pathogenesis and treatment resistance in cancers. Increasing attention has been paid to its anti‐oncogenic roles, due to its key functions in cellular senescence and the senescence‐as
Externí odkaz:
https://doaj.org/article/1878f5f2a8304ded8aac5a572702bc6d
Autor:
Jingjing Wang, Zixuan Huang, Li Ji, Cheng Chen, Quan Wan, Yu Xin, Zhening Pu, Koukou Li, Jiantong Jiao, Ying Yin, Yaling Hu, Lingli Gong, Rui Zhang, Xusheng Yang, Xiangming Fang, Mei Wang, Bo Zhang, Junfei Shao, Jian Zou
Publikováno v:
Advanced Science, Vol 9, Iss 26, Pp n/a-n/a (2022)
Abstract Sustained activation of signal transducer and activator of transcription 3 (STAT3) is a critical contributor in tumorigenesis and chemoresistance, thus making it an attractive cancer therapeutic target. Here, SH2 domain‐containing adapter
Externí odkaz:
https://doaj.org/article/c4a8974d0ce84d6aa7db2c50f496cfc3
Publikováno v:
Vaccines, Vol 11, Iss 5, p 1002 (2023)
Developing variant vaccines or multivalent vaccines is a feasible way to address the epidemic as the SARS-CoV-2 variants of concern (VOCs) posed an increased risk to global public health. The spike protein of the SARS-CoV-2 virus was usually used as
Externí odkaz:
https://doaj.org/article/cb1f6d90f44340d589fe3aca908f1292
Autor:
Yaling Hu, Zhihua Gao
Publikováno v:
Stress and Brain, Vol 1, Iss 1, Pp 46-58 (2021)
Microglia, the primary immune cells in the central nervous system (CNS), are key to the maintenance of homeostasis in the brain parenchyma. In the intact brain, microglia continuously survey the microenvironment with ramified processes. Upon disease
Externí odkaz:
https://doaj.org/article/8d39e5f0ce324f52856cb28fa09e44e6
Autor:
Yuxiang Liu, Wenyuan Liu, Ziyuan Zhang, Yaling Hu, Xiaodong Zhang, Yanyan Sun, Qingqing Lei, Dalin Sun, Ting Liu, Yanjun Fan, Hui Li, Wujie Ding, Jingai Fang
Publikováno v:
Renal Failure, Vol 43, Iss 1, Pp 128-140 (2021)
Diabetic nephropathy (DN) is a common complication of diabetes. Yishen capsule, composed of Chinese herbs, improves the clinical outcome in DN patients. However, its therapeutic potential and underlying mechanisms require further elucidation. Hence,
Externí odkaz:
https://doaj.org/article/8893498db4184214915f16bd0f2dddbe
Autor:
Surui Yao, Yuan Yin, Guoying Jin, Dan Li, Min Li, Yaling Hu, Yuyang Feng, Yuhang Liu, Zehua Bian, Xue Wang, Yong Mao, Jia Zhang, Zhimeng Wu, Zhaohui Huang
Publikováno v:
Cancer Medicine, Vol 9, Iss 16, Pp 5989-5998 (2020)
Abstract Background Nano‐sized extracellular vesicles secreted by cells play key roles in intercellular crosstalk, and appear to be an excellent biocompatible material as therapeutic cargoes in vivo. Previously, we have demonstrated that miR‐204
Externí odkaz:
https://doaj.org/article/1f27fb3aa35b4553a798790766e5d7b4