Výsledky vyhledávání - "Ya. E. Senilova"

Changes in mitochondrial NAD(P)H and glutamate-induced delayed calcium deregulation in cultured rat cerebellar granule neurons

Autor: A. M. Surin, B. I. Khodorov, Ya. E. Senilova, S. N. Zobova, Pinelis Vg, G. R. Tukhbatova

Publikováno v: Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 4:32-37

Changes in cytosolic [Ca2+]i, mitochondrial potential (ΔVm), and mitochondrial NAD(P)H autofluorescence were compared in experiments on cultured cerebellar granule cells co-loaded with Ca2+ indicator Fluo-3FF or mitochondrial potential-sensitive pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efdffff16abe8ec5c63fdb46180f7458
https://doi.org/10.1134/s1990747810010058

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Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity

Autor: T. P. Storozhevykh, L. A. Andreeva, Pinelis Vg, Ya. E. Senilova, N. F. Myasoyedov, G. R. Tukhbatova

Publikováno v: Bulletin of Experimental Biology and Medicine. 143:601-604

Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity. Incuba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f4591e694f39039b920ccf04ba2b52
https://doi.org/10.1007/s10517-007-0192-x

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Changes in ATP content in cerebellar granule cells during hyperstimulation of glutamate receptors: Possible role of NO and nitrite ions

Autor: Ya. E. Senilova, Pinelis Vg, V. P. Reutov, E. G. Sorokina, B. I. Khodorov

Publikováno v: Bulletin of Experimental Biology and Medicine. 143:442-445

In primary 7–8-day culture of cerebellar granule cells, glutamate exposure (100 µM, 10–240 min) induced a 60–30% drop in ATP level; during the postglutamate period ATP level completely recovered after 24 h. Inhibition of NO-synthase with L-NAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d09710abc1fbcf4ed134d17877aeab8
https://doi.org/10.1007/s10517-007-0151-6

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Effect of antibodies against AMPA glutamate receptors on brain neurons in primary cultures of the cerebellum and hippocampus

Autor: Pinelis Vg, V. P. Reutov, T. P. Storozhevykh, Oleg Granstrem, E. G. Sorokina, Ya. E. Senilova

Publikováno v: Bulletin of Experimental Biology and Medicine. 142:51-54

Rabbit antibodies against GluR1 subunit of AMPA glutamate receptors in a concentration of 1 mug/ml significantly increased intracellular Ca(2+)concentration and decreased mitochondrial potential in hippocampal neurons, i.e. produced changes typical o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1a59b6f44ef84269476bad2589b08e
https://doi.org/10.1007/s10517-006-0289-7

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Neuroprotective effect of KB-R7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization

Autor: Ya. E. Senilova, T. P. Storozhevykh, T. Brustovetsky, Pinelis Vg, Nickolay Brustovetsky

Publikováno v: Neurochemical research. 35(2)

KB-R7943, an inhibitor of a reversed Na(+)/Ca(2+) exchanger, exhibits neuroprotection against glutamate excitotoxicity. Taking into consideration that prolonged exposure of neurons to glutamate induces delayed calcium deregulation (DCD) and irreversi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f2cc0ec942d56fae7f285483102826
https://pubmed.ncbi.nlm.nih.gov/19771515

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Na+/Ca2+ exchange and regulation of cytoplasmic concentration of calcium in rat cerebellar neurons treated with glutamate

Autor: A. V. Vabnitz, G. R. Tukhbatova, Pinelis Vg, Ya. E. Senilova, E. G. Sorokina, T. P. Storozhevykh

Publikováno v: Biochemistry. Biokhimiia. 72(7)

In the present work, the forward and/or reversed Na+/Ca2+ exchange in cerebellar granular cells was suppressed by substitution of Na 0 + by Li+ before, during, and after exposure to glutamate for varied time and also using the inhibitor KB-R7943 of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc13f526154d6b5858becb10c5d27415
https://pubmed.ncbi.nlm.nih.gov/17680767

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Arachidonic acid enhances intracellular [Ca2+]i increase and mitochondrial depolarization induced by glutamate in cerebellar granule cells

Autor: Pinelis Vg, A. P. Bolshakov, Ya. E. Senilova, M. M. Mikhailova, B. I. Khodorov, A. M. Surin, E. G. Sorokina

Publikováno v: Biochemistry. Biokhimiia. 71(8)

Maturation of primary neuronal cultures is accompanied by an increase in the proportion of cells that exhibit biphasic increase in free cytoplasmic Ca2+ ([Ca2+]i) followed by synchronic decrease in electrical potential difference across the inner mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd4ba324aa5638204d00f7d812bc92f
https://pubmed.ncbi.nlm.nih.gov/16978149

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